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公开(公告)号：US11426407B2
公开(公告)日：2022-08-30
申请号：US16836155
申请日：2020-03-31
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： C07D213/82 , A61K31/506 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D403/12 , C07D413/14 , C07D213/73 , C07D231/20 , C07D401/04 , C07D235/24 , C07D403/10 , C07D239/34 , C07D407/12 , C07D209/18 , C07D209/49 , C07D213/64
摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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公开(公告)号：US09783501B2
公开(公告)日：2017-10-10
申请号：US14813911
申请日：2015-07-30
发明人： Sara Sabina Hadida-Ruah , Corey Anderson , Vijayalaksmi Arumugam , Iuliana Luci Asgian , Brian Richard Bear , Andreas P. Termin , James Philip Johnson
IPC分类号： A61K31/47 , C07D215/227 , C07D215/54 , C07D403/12 , C07D401/12 , C07D413/12 , C07D241/44 , C07D417/12 , A61K31/4709 , A61K31/498
CPC分类号： C07D215/54 , A61K31/47 , A61K31/4709 , A61K31/498 , C07D241/44 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
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公开(公告)号：US09393235B2
公开(公告)日：2016-07-19
申请号：US14699437
申请日：2015-04-29
发明人： Sara Sabina Hadida-Ruah , Corey Anderson , Vijayalaksmi Arumugam , Iuliana Luci Asgian , Brian Richard Bear , Andreas P. Termin , James Philip Johnson
IPC分类号： A61K31/04 , A61K31/4412 , C07D213/75 , C07D405/12 , C07D401/12
CPC分类号： C07D213/75 , A61K31/4412 , C07D401/12 , C07D405/12
摘要： The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
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公开(公告)号：US20160095858A1
公开(公告)日：2016-04-07
申请号：US14876525
申请日：2015-10-06
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Khatuya Haripada , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdgogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： A61K31/506 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D213/82
CPC分类号： A61K31/506 , A61J1/035 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , C07D209/18 , C07D209/42 , C07D209/49 , C07D213/64 , C07D213/73 , C07D213/82 , C07D213/84 , C07D231/12 , C07D231/14 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/14 , C07D407/12 , C07D413/14 , C07D417/12
摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
摘要翻译： 本发明的特征在于式I化合物或其药学上可接受的盐，其中R1，R2，R3，W，X，Y，Z，n，o，p和q如本文所定义，用于治疗CFTR介导 疾病如囊性纤维化。 本发明还特征在于药物组合物，治疗方法及其试剂盒。
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公开(公告)号：US20230233560A1
公开(公告)日：2023-07-27
申请号：US17865220
申请日：2022-07-14
发明人： Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
IPC分类号： A61K31/506 , C07D213/82 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/03 , C07D403/12 , C07D413/14 , C07D213/73 , C07D231/20 , C07D401/04 , C07D235/24 , C07D403/10 , C07D239/34 , C07D407/12 , C07D209/18 , C07D209/49 , C07D213/64
CPC分类号： A61K31/506 , C07D213/82 , A61K31/4418 , A61K31/444 , A61K31/44 , C07D213/84 , C07D231/14 , A61K31/415 , C07D209/42 , A61K31/404 , C07D401/12 , A61K31/4439 , C07D401/14 , C07D231/12 , A61K31/497 , C07D417/12 , C07D405/14 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4525 , A61J1/035 , C07D403/12 , C07D413/14 , C07D213/73 , C07D231/20 , C07D401/04 , C07D235/24 , C07D403/10 , C07D239/34 , C07D407/12 , C07D209/18 , C07D209/49 , C07D213/64
摘要： The present invention features a compound of formula I:
or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.-
公开(公告)号：US10022352B2
公开(公告)日：2018-07-17
申请号：US15078800
申请日：2016-03-23
发明人： Sara Sabina Hadida Ruah , Peter Diederik Jan Grootenhuis , Fredrick F. Van Goor , Jinglan Zhou , Brian Richard Bear , Mark Thomas Miller , Jason McCartney , Mehdi Michel Djamel Numa
IPC分类号： A61K31/405 , A61K31/404 , A61K45/06 , A61K9/28 , C07D403/12 , C07D405/14 , A61K31/4045 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , C07D233/64 , C07D405/12 , C07D471/04 , C07D487/04 , C07D209/08 , G01N33/50 , A61K31/47 , G01N33/68
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US20170037009A1
公开(公告)日：2017-02-09
申请号：US15174896
申请日：2016-06-06
发明人： Sara Sabina Hadida-Ruah , Corey Anderson , Vijayalaksmi Arumugam , Iuliana Luci Asgian , Brian Richard Bear , Andreas P. Termin , James Philip Johnson
IPC分类号： C07D213/75 , A61K31/4412
CPC分类号： C07D213/75 , A61K31/4412 , C07D401/12 , C07D405/12
摘要： The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
摘要翻译： 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括疼痛）的方法。
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公开(公告)号：US20150328196A1
公开(公告)日：2015-11-19
申请号：US14809841
申请日：2015-07-27
发明人： Sara Sabina Hadida-Ruah , Corey Anderson , Vijayalaksmi Arumugam , Iuliana Luci Asgian , Brian Richard Bear , Andreas P. Termin , James Philip Johnson
IPC分类号： A61K31/44 , C07C235/64 , A61K31/192 , C07D213/79
CPC分类号： A61K31/44 , A61K31/192 , C07C235/64 , C07D213/79
摘要： The invention relates to amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
摘要翻译： 本发明涉及可用作钠通道抑制剂的式I和I'或其药学上可接受的盐的酰胺化合物：本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法 ，包括疼痛。
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公开(公告)号：US09108903B2
公开(公告)日：2015-08-18
申请号：US14167741
申请日：2014-01-29
发明人： Sara Sabina Hadida-Ruah , Corey Anderson , Vijayalaksmi Arumugam , Iuliana Luci Asgian , Brian Richard Bear , Andreas P. Termin , James Philip Johnson
IPC分类号： C07C235/64 , C07D213/79
CPC分类号： A61K31/44 , A61K31/192 , C07C235/64 , C07D213/79
摘要： The invention relates to amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
摘要翻译： 本发明涉及可用作钠通道抑制剂的式I和I'或其药学上可接受的盐的酰胺化合物：本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法 ，包括疼痛。
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公开(公告)号：US09051270B2
公开(公告)日：2015-06-09
申请号：US14167759
申请日：2014-01-29
发明人： Sara Sabina Hadida-Ruah , Corey Anderson , Vijayalaksmi Arumugam , Iuliana Luci Asgian , Brian Richard Bear , Andreas P. Termin , James Philip Johnson
IPC分类号： A61K31/04 , C07D213/75 , C07D405/12 , C07D401/12
CPC分类号： C07D213/75 , A61K31/4412 , C07D401/12 , C07D405/12
摘要： The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
摘要翻译： 本发明涉及可用作钠通道抑制剂的式I和I'的吡啶酮酰胺化合物或其药学上可接受的盐：本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种 疾病，包括疼痛。
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