公开(公告)号：US4118652A

公开(公告)日：1978-10-03

申请号：US777364

申请日：1977-03-14

Applicant: Victor A. Vaguine

Inventor： Victor A. Vaguine

IPC: H01J23/24 ,  H01J23/36 ,  H05H9/04 ,  H01J25/10

CPC classification number: H05H9/04 ,  H01J23/24 ,  H01J23/36

Abstract: In the field of side-cavity coupled accelerators the accelerating cavity to which the accelerating power input is connected has preferably a smaller diameter than the other accelerating cavities. A side cavity is connected by a separate passage to the accelerating cavities of different diameter it couples together, whereby the areas of the coupling irises formed where said passages enter said accelerating cavities can be independently controlled by selecting the length of the respective passage. This separate passage arrangement is particularly described in an accelerator which comprises a plurality of interlaced substructures, with each substructure having a plurality of accelerating cavities disposed along the particle beam path and having side cavities disposed away from the beam path for electromagnetically coupling the accelerating cavities. A standing radio-frequency electromagnetic wave is fed to an accelerating cavity in each substructure so there are plural driven cavities in a single accelerator. Thus, the separate coupling passage arrangement between the side cavity and the accelerating cavities it couples is particularly valuable in said multiple substructure arrangement.

Abstract translation: 在侧腔耦合加速器的领域中，加速功率输入连接到的加速腔优选地具有比其它加速腔更小的直径。 侧腔通过单独的通道连接到不同直径的加速腔，它耦合在一起，从而通过选择相应通道的长度可以独立地控制形成在所述通道进入所述加速腔的耦合孔的区域。 这种单独的通道布置在包括多个交错子结构的加速器中特别描述，每个子结构具有沿着粒子束路径设置的多个加速腔，并且具有远离光束路径设置的侧腔，用于电磁耦合加速腔。 站立的射频电磁波被馈送到每个子结构中的加速腔，因此在单个加速器中有多个从动腔。 因此，在侧腔和其耦合的加速腔之间的单独的联接通道布置在所述多个子结构布置中是特别有价值的。

公开(公告)号：US4122373A

公开(公告)日：1978-10-24

申请号：US754650

申请日：1976-12-27

Applicant: Victor A. Vaguine

Inventor： Victor A. Vaguine

IPC: H01J23/24 ,  H01J23/36 ,  H05H9/04 ,  H01J25/10

CPC classification number: H05H9/04 ,  H01J23/24 ,  H01J23/36

Abstract: A standing-wave linear charged particle accelerator is disclosed which comprises a plurality of interlaced substructures, with each substructure having a plurality of accelerating cavities disposed along the particle beam path and having side cavities disposed away from the beam path for electromagnetically coupling the accelerating cavities. A standing radio-frequency electromagnetic wave is supported in each substructure, with the wave in each substructure being phased with respect to the wave in every other substructure so that the particle beam will experience a maximum energy gain throughout its path through the accelerator. A single input waveguide is divided into plural branches to individually drive each of the substructures.

Abstract translation: 公开了一种驻波线性带电粒子加速器，其包括多个交错子结构，每个子结构具有沿着粒子束路径设置的多个加速腔，并且具有远离光束路径设置的侧腔，用于电磁耦合加速腔。 在每个子结构中支持立体射频电磁波，每个子结构中的波相对于每个其他子结构中的波相位，使得粒子束在其穿过加速器的整个路径中将经历最大的能量增益。 单个输入波导被分成多个分支以单独驱动每个子结构。

公开(公告)号：US3969086A

公开(公告)日：1976-07-13

申请号：US513021

申请日：1974-10-08

Applicant: Victor A. Vaguine ,  Dennis R. Nichols

Inventor： Victor A. Vaguine ,  Dennis R. Nichols

IPC: C04B37/02 ,  H01P1/38 ,  B32B15/04

CPC classification number: H01P1/38 ,  C04B37/026 ,  C04B2237/12 ,  C04B2237/122 ,  C04B2237/124 ,  C04B2237/125 ,  C04B2237/34 ,  C04B2237/40 ,  C04B2237/708 ,  C04B2237/72 ,  C04B2237/86 ,  Y10S428/926 ,  Y10S428/928 ,  Y10T428/12611 ,  Y10T428/12889 ,  Y10T428/1291 ,  Y10T428/12986

Abstract: A ferrite-to-metal bond suitable for the environment of a high-power microwave circulator is disclosed. The bonding surface of a gyromagnetic ferrite or garnet button is metallized by a sputtering process that deposits successive layers of nichrome, copper and gold thereon. During the sputtering process, a flexible stainless steel band surrounds the button to prevent sputtered material from being deposited on other than the bonding surface of the button. The metallized bonding surface is then soldered to a metal wall of the circulator. The bond so formed is capable of withstanding a peak power level in the circulator of 2.0 megawatts and an average power level of 3.5 kilowatts under standing-wave conditions.

Abstract translation: 公开了一种适用于大功率微波环流器的环境的铁氧体对金属键。 旋磁铁氧体或石榴石钮扣的接合表面通过溅射工艺进行金属化，其中沉积连续的镍铬合金，铜和金。 在溅射过程中，柔性不锈钢带围绕按钮以防止溅射材料沉积在按钮的接合表面以外。 然后将金属化接合表面焊接到循环器的金属壁。 如此形成的结合能够在驻波器条件下承受循环器的峰值功率水平为2.0兆瓦，平均功率水平为3.5千瓦。

公开(公告)号：US4397314A

公开(公告)日：1983-08-09

申请号：US289127

申请日：1981-08-03

Applicant: Victor A. Vaguine

Inventor： Victor A. Vaguine

IPC: A61B18/18 ,  A61N5/00 ,  A61N5/02 ,  A61N1/40

CPC classification number: A61B18/18 ,  A61B18/1815 ,  A61N5/02

Abstract: A hyperthermia treatment system has multiple applicators and multiple temperature sensors for controlling the operation of the hyperthermia system. A temperature sensor probe implanted within a tumor provides a temperature signal for controlling and optimizing the power input to multiple applicators to maintain the system output during the treatment period at a predetermined control temperature. Temperature sensors implanted in the region of the healthy tissue provide temperature signals to override the controls providing power input to the applicators to prevent injury to healthy tissues. Individual microwave applicators are evaluated during the hyperthermia treatment to determine their effect on the overall heating pattern for optimizing the heating pattern.

Abstract translation: 高热治疗系统具有多个施用器和多个温度传感器，用于控制高热系统的操作。 植入肿瘤内的温度传感器探针提供温度信号，用于控制和优化对多个施用器的功率输入，以在处理期间将系统输出维持在预定的控制温度。 植入健康组织区域的温度传感器提供温度信号以覆盖控制器，从而为施加器提供功率输入，以防止对健康组织的损伤。 在高热处理期间评估单个微波施加器以确定其对整体加热模式的影响以优化加热模式。

公开(公告)号：US4024426A

公开(公告)日：1977-05-17

申请号：US546379

申请日：1975-02-03

Applicant: Victor A. Vaguine

Inventor： Victor A. Vaguine

IPC: H05H9/04 ,  H01J25/10

CPC classification number: H05H9/04

Abstract: A standing-wave linear charged particle accelerator is disclosed which comprises a plurality of interlaced substructures, with each substructure having a plurality of accelerating cavities disposed along the particle beam path and having side cavities disposed away from the beam path for electromagnetically coupling the accelerating cavities. A standing radio-frequency electromagnetic wave is supported in each substructure, with the wave in each substructure being phase with respect to the wave in every other substructure so that the particle beam will experience a maximum energy gain throughout its path through the accelerator. This interlaced substructure configuration minimizes the transit time of the particles across the gap of each accelerating cavity and makes it possible to operate the accelerator without radio-frequency breakdown at a power level that provides a substantially higher average value of the accelerating electric field along the beam path than has heretofore been obtainable.

Abstract translation: 公开了一种驻波线性带电粒子加速器，其包括多个交错子结构，每个子结构具有沿着粒子束路径设置的多个加速腔，并且具有远离光束路径设置的侧腔，用于电磁耦合加速腔。 在每个子结构中支持立体射频电磁波，每个子结构中的波相对于每个其他子结构中的波是相位的，使得粒子束在整个加速器的整个路径中将经历最大的能量增益。 这种交错子结构配置使颗粒跨越每个加速腔的间隙的通过时间最小化，并且使得可以在提供沿着光束的加速电场的基本上更高的平均值的功率水平下操作加速器而不进行射频击穿 路径比以前可以获得。

公开(公告)号：US4589424A

公开(公告)日：1986-05-20

申请号：US525182

申请日：1983-08-22

Applicant: Victor A. Vaguine

Inventor： Victor A. Vaguine

IPC: A61N5/02

CPC classification number: A61N5/02

Abstract: A direct contact microwave hyperthermia applicator includes a plurality of rectangular waveguide sections each having a radiating aperture. The waveguide sections are mounted with their long sides abutting. A pair of shutter elements for individually varying the radiating aperture is associated with each of the waveguide sections. The shutters can be adjusted to form a desired composite aperture which produces a radiation pattern adapted for efficient hyperthermia treatment of a tumor having a prescribed size, shape and location. Microwave power supplied to the radiating elements can be varied in phase and power level to further control the radiation pattern.

Abstract translation: 直接接触微波热疗器包括多个具有辐射孔的矩形波导部分。 波导部分以其长边邻接安装。 用于单独改变辐射孔的一对快门元件与每个波导部分相关联。 可以调节百叶窗以形成期望的复合孔，其产生适于对具有规定尺寸，形状和位置的肿瘤进行有效热疗治疗的辐射图。 提供给辐射元件的微波功率可以在相位和功率水平上变化，以进一步控制辐射图。

公开(公告)号：US4446874A

公开(公告)日：1984-05-08

申请号：US335631

申请日：1981-12-30

Applicant: Victor A. Vaguine

Inventor： Victor A. Vaguine

IPC: A61N5/04 ,  A61N5/02

CPC classification number: A61N5/04

Abstract: An improved microwave applicator includes a frequency tuner discoupled from an input power coupling tuner. The frequency tuner includes parallel elongated dielectric bars axially adjustable in a dielectric-filled waveguide. A central passageway space is provided between the dielectric bars for incorporation of an input coupling tuner in the form of a magnetic loop assembly. The magnetic loop assembly includes a metal loop connected to a metal block and means for axially adjusting the position of the loop assembly within the central passageway space between the elongated dielectric members. Frequency and input coupling tuning controls, as well as the microwave input connector, are located behind the closed end of the waveguide applicator to facilitate optimization of mutual positioning of multiple applicators.

Abstract translation: 改进的微波施加器包括与输入功率耦合调谐器耦合的频率调谐器。 频率调谐器包括在介质填充波导中可轴向调节的平行细长介质棒。 中间通道空间设置在电介质条之间，用于结合以磁环组件形式的输入耦合调谐器。 磁环组件包括连接到金属块的金属环和用于轴向调节环组件在细长电介质构件之间的中心通道空间内的位置的装置。 频率和输入耦合调谐控制以及微波输入连接器位于波导管的封闭端的后面，以便优化多个施加器的相互定位。

公开(公告)号：US4286192A

公开(公告)日：1981-08-25

申请号：US84284

申请日：1979-10-12

Applicant: Eiji Tanabe ,  Victor A. Vaguine

Inventor： Eiji Tanabe ,  Victor A. Vaguine

IPC: H05H9/00 ,  H05H7/12 ,  H05H7/18 ,  H05H9/04 ,  H01J25/10

CPC classification number: H05H9/04 ,  H05H7/12 ,  H05H7/18

Abstract: Variable energy selection is accomplished in a side cavity coupled standing wave linear accelerator by shifting the phase of the field in a selected side coupling cavity by .pi. radians where such side coupling cavity is disposed intermediate groups of accelerating cavities. For an average acceleration energy of E.sub.1 (MeV) per interaction cavity, and a total number of N interaction cavities, the total energy gain is E.sub.1 (N-2N.sub.1) where N.sub.1 is the number of interaction cavities traversed beyond the incidence of the phase shift. The phase shift is most simply accomplished by changing the selected side cavity configuration mechanically in repeatable manner so that its resonant excitation is switched from TM.sub.010 mode to either TM.sub.011 or TEM modes. Thus, the total energy gain can be varied without changing the RF input power. In addition, the beam energy spread is unaffected.

Abstract translation: 可变能量选择在侧腔耦合的驻波直线加速器中通过在选定的侧联接腔中移动场的相位通过pi弧度来实现，其中这种侧耦合腔设置在加速腔的中间组中。 对于每个相互作用腔的E1（MeV）的平均加速能量和N个相互作用空腔的总数，总能量增益为E1（N-2N1），其中N1是穿过超过相移入射的相互作用空腔的数量 。 通过以可重复的方式机械地改变所选择的侧腔结构，使得其谐振激励从TM010模式切换到TM011或TEM模式，最简单地实现相移。 因此，可以在不改变RF输入功率的情况下改变总能量增益。 此外，光束能量传播不受影响。

公开(公告)号：US4974587A

公开(公告)日：1990-12-04

申请号：US288414

申请日：1988-12-22

Applicant: Paul F. Turner ,  Victor A. Vaguine

Inventor： Paul F. Turner ,  Victor A. Vaguine

IPC: A61N1/06 ,  A61N5/02

CPC classification number: A61N5/02 ,  A61N1/06

Abstract: The use of an externally located dipole array mounted upon a high dielectric material for heating biological tissues is disclosed. This dipole array provides improved flexibility and adaptability to varying tissue surface contours. The adjustable dipole antenna array or other type of electromagnetic antenna applicators provides an ability to adapt the heating pattern to meet the needs of the different tissue zones, applicator positions, and applicator mechanical scanning by adjusting individual power amplitude and phase to the various elements of the applicator array for controlling the heat distribution of heat in target tissue having areas of varying power absorption and cooling effect (blood flow). The array design may also include capacitively coupled metal elements in the form of strips, patches or tubes. The electromagnetic heating elements are attached to a transparent flexible dielectric fluid filled envelope, tube, or bag for viewing both the tissue surface being heated and positioning the applicators and temperature sensors. The flexibility of this array provides uniform heating of a diversity of surface contours. Also, an electromechanical positioning system for the applications allows the applicators to be selectively positioned in the tubes, and thereafter repositioned during treatment.

Abstract translation: 公开了使用安装在高电介质材料上的外置偶极子阵列来加热生物组织。 该偶极阵列提供改善的组织表面轮廓的灵活性和适应性。 可调式偶极天线阵列或其他类型的电磁天线施加器提供了通过将各个功率振幅和相位调整到各种元件的适应性来适应加热模式以满足不同组织区域，施加器位置和施加器机械扫描的需要的能力 用于控制具有变化的功率吸收和冷却效果（血流）的区域的靶组织中的热分布的施加器阵列。 阵列设计还可以包括带状，贴片或管形式的电容耦合金属元件。 电磁加热元件附着到透明柔性介质流体填充的外壳，管或袋上，用于观察被加热的组织表面并定位涂布器和温度传感器。 该阵列的灵活性提供了各种表面轮廓的均匀加热。 此外，用于应用的机电定位系统允许施用器选择性地定位在管中，并且此后在治疗期间重新定位。

公开(公告)号：US4556070A

公开(公告)日：1985-12-03

申请号：US547307

申请日：1983-10-31

Applicant: Victor A. Vaguine ,  Robert H. Giebeler, Jr. ,  Albert H. McEuen

Inventor： Victor A. Vaguine ,  Robert H. Giebeler, Jr. ,  Albert H. McEuen

IPC: A61B17/00 ,  A61B17/22 ,  A61N5/02 ,  A61N7/02 ,  A61N1/00

CPC classification number: A61N5/02 ,  A61N7/02 ,  A61B2017/00057 ,  A61B2017/00084 ,  A61B2017/00092 ,  A61B2017/22028

Abstract: A direct contact hyperthermia applicator includes an ultrasonic lens with an array of ultrasonic transducers and an array of microwave antenna elements mounted behind the lens and positioned for transmission of ultrasonic wave energy and microwave energy therethrough. The antenna elements can be waveguide sections having radiating apertures or microstrip antenna elements. A fluid enclosure is defined between the front surface of the lens and a thin rubber sheet sealed around the periphery of the lens. During hyperthermia treatment, the rubber sheet conforms to the contours of the patient's body. The fluid, which is typically cooled distilled water, improves coupling of microwave energy and ultrasonic wave energy into the patient's body and cools the surface region.

Abstract translation: 直接接触式热疗施加器包括具有超声波换能器阵列的超声波透镜和安置在透镜后面的微波天线元件阵列，并定位成用于传输超声波能量和微波能量。 天线元件可以是具有辐射孔或微带天线元件的波导部分。 流体外壳限定在透镜的前表面和密封在透镜周边之间的薄橡胶片之间。 在热疗期间，橡胶片符合患者身体的轮廓。 通常是冷却蒸馏水的流体改善了微波能量和超声波能量耦合到患者体内并冷却表面区域。