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公开(公告)号：US06884866B2
公开(公告)日：2005-04-26
申请号：US10274719
申请日：2002-10-18
摘要： The present invention discloses apparatus and methods of inducing bubble nucleation to overcome problems commonly associated with preservation by foam formation. Specifically, the invention relates to methods of using bubble nucleation in foam formation to preserve sensitive biological materials. Preferred methods of inducing bubble nucleation include, mixing, chamber rotation, crystals, and ultrasound.
摘要翻译： 本发明公开了引发气泡成核的装置和方法，以克服与通过泡沫形成的保存通常相关的问题。 具体地，本发明涉及在泡沫形成中使用气泡成核以保存敏感的生物材料的方法。 引发气泡成核的优选方法包括混合，室旋转，晶体和超声波。
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2.发明授权Industrial scale barrier technology for preservation of sensitive biological materials 失效用于保存敏感生物材料的工业规模阻隔技术公开(公告)号：US06692695B1
公开(公告)日：2004-02-17
申请号：US09589381
申请日：2000-06-07
IPC分类号： B01J1900
CPC分类号： A61K9/122 , A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/1629 , A61K9/1694 , A61K47/26 , C12N1/04
摘要： This invention relates to barrier methods for preserving sensitive biological materials as a porous foam, subsequently crushing the foam to form a powder, and optionally formulating mixtures of preserved powdered biological materials. The invention also encompasses an apparatus for integrating the methods of foam formation and subsequent crushing of the preserved biological materials using barrier technology.
摘要翻译： 本发明涉及用于将敏感生物材料保存为多孔泡沫的隔离方法，随后将泡沫破碎以形成粉末，以及任选配制保留的粉末状生物材料的混合物。 本发明还包括一种使用阻挡技术整合泡沫形成方法和随后破碎保存的生物材料的装置。
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3.发明授权Industrial scale barrier technology for preservation of sensitive biological materials at ambient temperatures 失效用于在环境温度下保存敏感生物材料的工业规模阻隔技术公开(公告)号：US06306345B1
公开(公告)日：2001-10-23
申请号：US09306137
申请日：1999-05-06
IPC分类号： B01J1900
CPC分类号： A61K47/26 , A61K9/122 , A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/1629 , A61K9/1694 , C12N1/04 , Y10S516/928
摘要： This invention relates to barrier methods for preserving sensitive biological materials as a porous foam, subsequently crushing the foam to form a powder, and optionally formulating mixtures of preserved powdered biological materials. The invention also encompasses an apparatus for integrating the methods of foam formation and subsequent crushing of the preserved biological materials using barrier technology.
摘要翻译： 本发明涉及用于将敏感生物材料保存为多孔泡沫的隔离方法，随后将泡沫破碎以形成粉末，以及任选配制保留的粉末状生物材料的混合物。 本发明还包括一种使用阻挡技术整合泡沫形成方法和随后破碎保存的生物材料的装置。
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公开(公告)号：US5759571A
公开(公告)日：1998-06-02
申请号：US84218
申请日：1993-06-23
CPC分类号： A61K31/7036 , A61K9/127
摘要： A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided where the hydration temperature is significantly below the transition temperature of the formulation. A method for the treatment of drug susceptible and drug resistant bacteria.
摘要翻译： PCT No.PCT / US93 / 04501 Sec。 371日期：1993年6月23日 102（e）1993年6月23日日期PCT 1993年5月11日提交的脂质体氨基糖苷制剂，其包含中性脂质，带负电荷的脂质和固醇。 该制剂含有平均粒度低于100nm的单层囊泡。 提供了含有氨基糖苷类的脂质体的方法，其中水合温度明显低于制剂的转变温度。 一种治疗药物易感和耐药细菌的方法。
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公开(公告)号：US5756120A
公开(公告)日：1998-05-26
申请号：US468497
申请日：1995-06-06
CPC分类号： A61K31/7036 , A61K9/127
摘要： A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided where the hydration temperature is significantly below the transition temperature of the formulation. A method for the treatment of drug susceptible and drug resistant bacteria.
摘要翻译： 包含中性脂质，带负电荷的脂质和固醇的脂质体氨基糖苷制剂。 该制剂含有平均粒度低于100nm的单层囊泡。 提供了含有氨基糖苷类的脂质体的方法，其中水合温度明显低于制剂的转变温度。 一种治疗药物易感和耐药细菌的方法。
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公开(公告)号：US5958449A
公开(公告)日：1999-09-28
申请号：US82633
申请日：1998-05-21
CPC分类号： A61K31/7036 , A61K9/127 , A61K9/1272
摘要： A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipid and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided. A method is also provide for the treatment of drug susceptible and drug resistant bacteria.
摘要翻译： 包含中性脂质，带负电荷的脂质和甾醇的脂质体氨基糖苷制剂。 该制剂含有平均粒度低于100nm的单层囊泡。 提供了制备含有氨基糖苷类的脂质体的方法。 还提供了用于治疗药物易感和耐药细菌的方法。
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公开(公告)号：US5756121A
公开(公告)日：1998-05-26
申请号：US469157
申请日：1995-06-06
申请人： Kevin R. Bracken
发明人： Kevin R. Bracken
IPC分类号： A61K9/127 , A61K9/133 , A61K31/70 , A61K31/7036 , A61K47/24 , A61K47/28 , A61P31/04 , A61P31/06
CPC分类号： A61K31/7036 , A61K9/127
摘要： A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is provided where the hydration temperature is significantly below the transition temperature of the formulation. A method for the treatment of drug susceptible and drug resistant bacteria.
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公开(公告)号：US5028297A
公开(公告)日：1991-07-02
申请号：US534651
申请日：1990-06-06
申请人： Kevin R. Bracken
发明人： Kevin R. Bracken
CPC分类号： B01D1/225 , A61K9/1277 , Y10S159/16 , Y10S203/13
摘要： A thin-film evaporator for preparing liposomes in commercial quantities provides a film-forming zone of uniform thickness which enables the uniform evaporation of an organic solvent to form a film of uniform thickness, followed by in situ hydration of the film in an aqueous phase by agitation with a rotor.
摘要翻译： 用于以商业量制备脂质体的薄膜蒸发器提供均匀厚度的成膜区域，其能够均匀蒸发有机溶剂以形成均匀厚度的膜，随后通过在水相中的膜原位水合 用转子搅拌。
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公开(公告)号：US06221388B1
公开(公告)日：2001-04-24
申请号：US09407798
申请日：1999-09-28
IPC分类号： A61K9127
CPC分类号： A61K31/7036 , A61K9/127 , A61K9/1272
摘要： A liposomal aminoglycoside formulation comprising a neutral lipid, a negatively charged lipids and a sterol. The formulation contains unilamellar vesicles having an average size below 100 nm. A process of making liposomes containing an aminoglycoside is also provided. A method is also provided for the treatment of drug susceptible and drug resistant bacteria.
摘要翻译： 包含中性脂质，带负电荷的脂质和固醇的脂质体氨基糖苷制剂。 该制剂含有平均粒度低于100nm的单层囊泡。 还提供了制备含有氨基糖苷类的脂质体的方法。 还提供了用于治疗药物易感和耐药细菌的方法。
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公开(公告)号：US4935171A
公开(公告)日：1990-06-19
申请号：US303473
申请日：1989-01-27
申请人： Kevin R. Bracken
发明人： Kevin R. Bracken
CPC分类号： B01D1/225 , A61K9/1277 , Y10S436/829 , Y10S514/832 , Y10S514/833
摘要： A single-vessel method is provided for preparing liposomes in commercial quantities by forming a homogeneous and uniform lipid film in a thin-film evaporator by evaporation of the organic solvent, followed by in situ hydration of the film in an aqueous phase by agitation with the rotor.
摘要翻译： 提供单容器方法，用于通过在薄膜蒸发器中通过蒸发有机溶剂形成均匀且均匀的脂质膜，然后在水相中通过搅拌进行原位水合，以商业量制备脂质体 转子。
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