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公开(公告)号：US07122364B1
公开(公告)日：2006-10-17
申请号：US09714935
申请日：2000-11-17
CPC分类号： C12N9/22 , C12Q1/6813 , C12Q2521/301
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
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公开(公告)号：US06555357B1
公开(公告)日：2003-04-29
申请号：US09684938
申请日：2000-10-06
IPC分类号： C12N1555
CPC分类号： C12N9/22 , C12Q1/6823 , Y10S435/975 , C12Q2525/301 , C12Q2561/109
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic acid sequences. Structure-specific nucleases derived from a variety of thermostable organisms are provided. These structure-specific nucleases are used to cleave target-dependent cleavage structures, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明涉及核酸序列的检测和表征以及核酸序列的变化的方法。 本发明还涉及用于检测和表征核酸序列的改进的切割装置。 提供了衍生自各种热稳定生物体的结构特异性核酸酶。 这些结构特异性核酸酶用于切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US20080199936A1
公开(公告)日：2008-08-21
申请号：US11926006
申请日：2007-10-28
IPC分类号： C12N9/00
CPC分类号： C12N9/1252 , A61K38/00 , C07K2319/02 , C12N9/22 , C12Q1/6823 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US06562611B1
公开(公告)日：2003-05-13
申请号：US09308825
申请日：1999-10-08
IPC分类号： C12N922
CPC分类号： C12N9/22 , C12Q1/6823 , Y10S435/975 , C12Q2525/301 , C12Q2561/109
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic acid sequences. Structure-specific nucleases derived from a variety of thermostable organisms are provided. These structure-specific nucleases are used to cleave target-dependent cleavage structures, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明涉及核酸序列的检测和表征以及核酸序列的变化的方法。 本发明还涉及用于检测和表征核酸序列的改进的切割装置。 提供了衍生自各种热稳定生物体的结构特异性核酸酶。 这些结构特异性核酸酶用于切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US08182991B1
公开(公告)日：2012-05-22
申请号：US09684305
申请日：2000-10-06
CPC分类号： C12N9/22 , C12Q1/6816 , C12Q2521/301 , C12Q2527/125
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic acid sequences. Structure-specific nucleases derived from a variety of thermostable organisms are provided. These structure-specific nucleases are used to cleave target-dependent cleavage structures, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明涉及核酸序列的检测和表征以及核酸序列的变化的方法。 本发明还涉及用于检测和表征核酸序列的改进的切割装置。 提供了衍生自各种热稳定生物体的结构特异性核酸酶。 这些结构特异性核酸酶用于切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US6090606A
公开(公告)日：2000-07-18
申请号：US758314
申请日：1996-12-02
CPC分类号： C12Q1/6823 , C12N9/22 , C12Q1/683
摘要： The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic acid sequences. Structure-specific nucleases derived from a variety of thermostabe organisms are provided. These structure-specific nucleases are used to cleave target-dependent cleavage structures, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明涉及核酸序列的检测和表征以及核酸序列的变化的方法。 本发明还涉及用于检测和表征核酸序列的改进的切割装置。 提供了衍生自各种恒温器生物体的结构特异性核酸酶。 这些结构特异性核酸酶用于切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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公开(公告)号：US20060183207A1
公开(公告)日：2006-08-17
申请号：US11260845
申请日：2005-10-27
IPC分类号： C12N9/00
CPC分类号： C12N9/1252 , A61K38/00 , C07K2319/02 , C12N9/22 , C12Q1/6823 , C12Q2561/109
摘要： The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
摘要翻译： 本发明提供了用于切割和修饰核酸的新型切割剂和聚合酶。 裂解剂和聚合酶可用于例如核酸序列的检测和表征以及核酸序列的变化。 在一些实施方案中，使用各种酶的5'核酸酶活性来切割靶依赖性切割结构，从而指示特异性核酸序列的存在或其特定变体。
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