公开(公告)号：US06308105B1

公开(公告)日：2001-10-23

申请号：US09353621

申请日：1999-07-15

申请人： Victor P.J. Duysens ,  Leo Kretzers ,  Paulus Van Venrooij ,  Paulus A. A. Gubbels ,  Paulus G. Adams

发明人： Victor P.J. Duysens ,  Leo Kretzers ,  Paulus Van Venrooij ,  Paulus A. A. Gubbels ,  Paulus G. Adams

IPC分类号： A61N105

CPC分类号： A61N1/0551 ,  A61N1/0556 ,  A61N1/36071

摘要： A system for providing electrical stimulation to the trigeminal nerve through a lead. The lead features a lead body, a coupling for connecting a lead into a medical stimulator and a distal electrode assembly. The electrode assembly features a pair of oppositely disposed curved semi-circular cuffs disposed to conform a lumen therethrough. The ends of each cuff are mounted into a resilient hinge disposed upon the distal end of the lead body. The hinge biases the cuffs towards one another in such a manner that the lumen is maintained patent such that the nerve will remain therein. The hinge is further designed so as to be easily opened so as to spread the cuffs apart. Hinge opening is accomplished through a specialized implant tool, the implant tool being a generally cylindrical tube designed to meet about the lead body. A divergence in the lead body near the hinge permits the implant tool to engage the lead body in that section and thus forces the cuffs apart. In such a manner the cuffs may be opened so as to be implanted around the lead merely through manipulation of the proximal end of the lead body. Thus, this design permits the leads to be implanted using the so-called “key-hole” surgical approach. Additional embodiments of the lead are also disclosed.

摘要翻译： 用于通过铅提供对三叉神经的电刺激的系统。 引线具有引线体，用于将引线连接到医疗刺激器和远端电极组件的联接器。 电极组件具有一对相对设置的弯曲半圆形袖带，其设置成使腔通过其中。 每个箍的端部安装在设置在引线主体的远端上的弹性铰链中。 铰链将袖口朝向彼此偏压，使得保持腔内的专利使得神经将保留在其中。 铰链进一步被设计成容易打开以将袖口分开。 铰链开口通过专门的植入工具实现，植入工具是设计成围绕引线体相遇的大致圆柱形管。 在铰链附近的引线体中的分叉允许植入工具与该部分中的引线主体接合，从而将袖带分开。 以这种方式，可以打开袖带以仅通过操纵引线主体的近端来植入在引线周围。 因此，这种设计允许使用所谓的“钥匙孔”手术方法植入导线。 还公开了引线的附加实施例。

公开(公告)号：US5843150A

公开(公告)日：1998-12-01

申请号：US947107

申请日：1997-10-08

申请人： Chrit W. Dreessen ,  Paulus A. A. Gubbels ,  Paulus G. Adams ,  Victor P. J. Duysens

发明人： Chrit W. Dreessen ,  Paulus A. A. Gubbels ,  Paulus G. Adams ,  Victor P. J. Duysens

IPC分类号： A61N1/05 ,  A61N1/02

CPC分类号： A61N1/0529 ,  A61N1/0539

摘要： A system and method for providing electrical and/or fluid treatment within a patient's brain, the system and method utilizing a feedthrough assembly made of a compressible material, and a disk-like pinch-on part, or resilient clamping part, which is secured around the feedthrough assembly to provide radially inward compressive force to reliably fix the lead after it has been positioned relative to the patient's skull. The feedthrough assembly is suitably made of a compressible biocompatible material such as silicone rubber, and has a annular receiving groove which is located so that it is accessible above the cranium after the feedthrough assembly is fixed within a burr hole in the patient's head. The pinch-on part, or clamping means is manufactured in a normally closed position, but can be opened, as by use of a forceps-type instrument, for positioning around the assembly annular groove. The anchored lead or catheter member is operatively connected to an implantable pulse generator or fluid pump, or both, to provide a system for treatment within the patient's brain.

摘要翻译： 一种用于在患者的大脑内提供电和/或流体治疗的系统和方法，所述系统和方法利用由可压缩材料制成的馈通组件，以及盘状夹持部件或弹性夹持部件 所述馈通组件提供径向向内的压缩力，以在引线相对于患者的头骨定位之后可靠地固定引线。 馈通组件适当地由可压缩的生物相容性材料例如硅橡胶制成，并且具有环形容纳槽，该环形容纳凹槽定位成使得在馈通组件固定在患者头部的钻孔中之后可以在颅骨上方接近。 夹紧部件或夹紧装置制造在常闭位置，但是可以通过使用镊子式仪器打开，以围绕组件环形槽定位。 锚定的导线或导管构件可操作地连接到可植入脉冲发生器或流体泵，或两者，以提供用于在患者大脑内治疗的系统。

公开(公告)号：US08244379B2

公开(公告)日：2012-08-14

申请号：US11380234

申请日：2006-04-26

申请人： Koen Michels ,  Jean-Luc Jansens ,  Victor Duysens ,  Paulus G. Adams ,  Paulus Van Venrooij ,  Markus J. C. Lazeroms ,  Fredric W. Lindemans

发明人： Koen Michels ,  Jean-Luc Jansens ,  Victor Duysens ,  Paulus G. Adams ,  Paulus Van Venrooij ,  Markus J. C. Lazeroms ,  Fredric W. Lindemans

IPC分类号： A61N1/05

CPC分类号： A61N1/0587

摘要： Certain aspects of the disclosure pertain to methods and apparatus for providing positive fixation of medical components to a portion of incised pericardial tissue. Accordingly, a resilient member protrudes through an incision in the pericardium and produces a positive biasing force to adjacent pericardial tissue against a side surface of an attached body structure. The resilient member can optionally be compressed during implantation and then relaxed to thereafter provide the positive biasing force. Diverse medical components can thus be safely and reliably chronically deployed into the pericardial space, including without limitation, cardiac sensing/pacing, defibrillation and/or cardioversion electrodes, mechanical and/or metabolic sensors and the like. More than one body structure can be linked to a single medical electrical lead and the medical components can couple within and/or upon a portion of the body structure, the resilient member, and the lead in myriad configurations.

摘要翻译： 本公开的某些方面涉及用于向切开的心包组织的一部分提供医疗部件的正面固定的方法和装置。 因此，弹性构件通过心包中的切口突出，并且相对于附接体结构的侧表面产生相邻心包组织的正偏置力。 弹性构件可以可选地在植入期间被压缩，然后松弛，之后提供正的偏压力。 因此，不同的医疗部件可以安全可靠地长期地部署到心包空间中，包括但不限于心脏感测/起搏，除颤和/或心脏复律电极，机械和/或代谢传感器等。 多个主体结构可以连接到单个医疗电引线，并且医疗部件可以在各种构造中联接在身体结构，弹性构件和引线的一部分内和/或之内。

公开(公告)号：US20090270962A1

公开(公告)日：2009-10-29

申请号：US12414384

申请日：2009-03-30

申请人： Zhongping Yang ,  Amy Elizabeth Thompson ,  Paulus G. Adams ,  Koen Michels

发明人： Zhongping Yang ,  Amy Elizabeth Thompson ,  Paulus G. Adams ,  Koen Michels

IPC分类号： A61N1/05 ,  B23P25/00

CPC分类号： A61N1/05

摘要： An implantable passive fixation lead is disclosed. The passive fixation lead comprises an elongate lead body having at least one elongate conductive element. The lead body includes a proximal end and a distal end. A support member has a first surface and a second surface. The second surface is coupled to the distal end of the lead body. A linking material is coupled to the first surface of the support member. A bioadhesive material is coupled to the linking material. A removable cover is placed over the bioadhesive material.

摘要翻译： 公开了可植入的被动固定引线。 被动固定引线包括具有至少一个细长导电元件的细长引线体。 引线体包括近端和远端。 支撑构件具有第一表面和第二表面。 第二表面联接到引线主体的远端。 连接材料联接到支撑构件的第一表面。 生物粘附材料与连接材料连接。 可移除的盖子放置在生物粘附材料上。

公开(公告)号：US09987484B2

公开(公告)日：2018-06-05

申请号：US13460944

申请日：2012-05-01

申请人： Markus J. C. Lazeroms ,  Paulus G. Adams

发明人： Markus J. C. Lazeroms ,  Paulus G. Adams

IPC分类号： A61B19/00 ,  A61N1/05 ,  A61B17/34 ,  A61B18/00 ,  A61B17/00 ,  A61B17/30 ,  A61N5/06

CPC分类号： A61N1/0587 ,  A61B17/3468 ,  A61B2017/00561 ,  A61B2017/00566 ,  A61B2017/306 ,  A61B2017/308 ,  A61B2018/00273 ,  A61B2018/00291 ,  A61N1/0592 ,  A61N2005/0649

摘要： A system and method enables delivery of an implantable medical lead to an implant location. A delivery tool of the system defines the delivery angle of the lead at the implant location. The delivery tool includes an elongate body having at least one lumen extending from a distal portion to a proximal portion. A suction cup is coupled to the distal portion of the elongate body. The suction cup may be configured to be collapsible in a first configuration, prior to deployment, and expandable in a second configuration. The system may include a suction source for drawing tissue at the implant location into the suction cup of the delivery tool that is disposed at the distal portion. The delivery angle of the lead tip is based on the interior cavity of the suction cup rather than the angle of insertion with the suctioned tissue.

公开(公告)号：US06907298B2

公开(公告)日：2005-06-14

申请号：US10045850

申请日：2002-01-09

申请人： Karel F. A. A. Smits ,  Jean J. G. Rutten ,  Paulus G. Adams

发明人： Karel F. A. A. Smits ,  Jean J. G. Rutten ,  Paulus G. Adams

IPC分类号： A61M25/00 ,  A61M25/01 ,  A61N1/05

CPC分类号： A61M25/0138 ,  A61M25/0144 ,  A61M25/0147 ,  A61M2025/0161

摘要： Elongated medical instruments adapted to be permanently or temporarily implanted in the mammalian body or used to access a site in the body to facilitate introduction of a further medical device, and methods and apparatus for deflecting the distal end and imparting curves in distal segments of such medical instruments within the body by manipulation of a proximal segment of the instrument outside the body are disclosed. Multiple portions of distal segments of a single one or distal segments of coaxially arranged distal segments of deflectable coiled wires are formed each having a line of spacers each functioning as a backbone along a side of the wire coil and formed in a variety of ways. One or more elongated movable wire extends through a coil lumen to one or more attachment point distal to each portion that can be pushed to widen and/or pulled to narrow the spacing of coil turns across the coil diameter from the line to induce a bend in all more proximal portions.

摘要翻译： 适于永久或临时植入哺乳动物体内或用于进入体内部位以便于引入另外的医疗装置的细长的医疗器械，以及用于偏转远端并在该医疗器械的远侧部分中赋予曲线的方法和装置 公开了通过在体外操纵器械的近端部分而在身体内的器械。 形成可同轴布置的可偏转线圈绕线的远端段的单个或远端段的远端段的多个部分，每个远侧段具有沿着线圈的一侧用作骨架的间隔线，并且以各种方式形成。 一个或多个细长的可动线延伸穿过线圈腔至一个或多个附接点，该连接点可远离每个部分，该连接点可被推动以加宽和/或拉动，从而使线圈的线圈间距从线路缩窄以引起弯曲 所有更多的近端部分。

公开(公告)号：US08594809B2

公开(公告)日：2013-11-26

申请号：US12414384

申请日：2009-03-30

申请人： Zhongping Yang ,  Amy Elizabeth Thompson ,  Paulus G. Adams ,  Koen Michels

发明人： Zhongping Yang ,  Amy Elizabeth Thompson ,  Paulus G. Adams ,  Koen Michels

IPC分类号： A61N1/18

CPC分类号： A61N1/05

摘要： An implantable passive fixation lead is disclosed. The passive fixation lead comprises an elongate lead body having at least one elongate conductive element. The lead body includes a proximal end and a distal end. A support member has a first surface and a second surface. The second surface is coupled to the distal end of the lead body. A linking material is coupled to the first surface of the support member. A bioadhesive material is coupled to the linking material. A removable cover is placed over the bioadhesive material.

摘要翻译： 公开了可植入的被动固定引线。 被动固定引线包括具有至少一个细长导电元件的细长引线体。 引线体包括近端和远端。 支撑构件具有第一表面和第二表面。 第二表面联接到引线主体的远端。 连接材料联接到支撑构件的第一表面。 生物粘附材料与连接材料连接。 可移除的盖子放置在生物粘附材料上。

公开(公告)号：US20130296879A1

公开(公告)日：2013-11-07

申请号：US13460944

申请日：2012-05-01

申请人： Markus J.C. Lazeroms ,  Paulus G. Adams

发明人： Markus J.C. Lazeroms ,  Paulus G. Adams

IPC分类号： A61B19/00

CPC分类号： A61N1/0587 ,  A61B17/3468 ,  A61B2017/00561 ,  A61B2017/00566 ,  A61B2017/306 ,  A61B2017/308 ,  A61B2018/00273 ,  A61B2018/00291 ,  A61N1/0592 ,  A61N2005/0649

摘要： A system and method enables delivery of an implantable medical lead to an implant location. A delivery tool of the system defines the delivery angle of the lead at the implant location. The delivery tool includes an elongate body having at least one lumen extending from a distal portion to a proximal portion. A suction cup is coupled to the distal portion of the elongate body. The suction cup may be configured to be collapsible in a first configuration, prior to deployment, and expandable in a second configuration. The system may include a suction source for drawing tissue at the implant location into the suction cup of the delivery tool that is disposed at the distal portion. The delivery angle of the lead tip is based on the interior cavity of the suction cup rather than the angle of insertion with the suctioned tissue.

摘要翻译： 一种系统和方法使得将可植入医疗引线传送到植入位置。 该系统的输送工具限定了在植入位置处的引线的输送角度。 递送工具包括细长体，其具有从远端部分延伸到近端部分的至少一个内腔。 吸盘联接到细长体的远端部分。 吸入杯可以被配置为在展开之前以第一构型可折叠并且可在第二构型中展开。 系统可以包括用于将植入位置处的组织抽吸到设置在远端部分的输送工具的吸盘中的抽吸源。 引线端的输送角度基于吸盘的内腔而不是与被抽吸的组织的插入角度。