公开(公告)号：US06993167B1

公开(公告)日：2006-01-31

申请号：US09473270

申请日：1999-12-27

申请人： Victor Skladnev ,  Alex Gutenev ,  Scott Menzies ,  Richard Thompson ,  Andrew Batrac ,  Leanne Bischoff ,  Roger Caffin ,  Stephen Rowe ,  Hugues Talbot ,  David Varvel ,  Peter West

发明人： Victor Skladnev ,  Alex Gutenev ,  Scott Menzies ,  Richard Thompson ,  Andrew Batrac ,  Leanne Bischoff ,  Roger Caffin ,  Stephen Rowe ,  Hugues Talbot ,  David Varvel ,  Peter West

IPC分类号： G06K9/00

CPC分类号： A61B5/444 ,  A61B5/0059 ,  G06F19/00

摘要： A system for collecting, storing and displaying dermatological images for the purpose of monitoring and diagnosis of skin conditions and skin cancers, including melanoma. A hand-held unit illuminates a section of the patient's skin, and an imaging device generates imaging signals from light derived from a skin section. Pairs of light output ports in the hand-held unit are arranged such that their intensity distributions overlap at their half-intensity levels so that the resulting summation of their intensities has a flat central region. Three image stores are maintained, one for lesion images, one for “nearby skin” images, and one for reference-white images. The “nearby skin” images are used by the system software to automatically determine the skin/lesion border. The reference white images are used to set the dynamic range of the instrument and to compensate for lighting irregularities. Two images of the same lesion taken at different times may be displayed simultaneously so that changes in the lesion may be determined. The calibration system is designed so that image data taken on any of multiple machines built to the same specification will be corrected back to a common reference standard to ensure absolute accuracy in colour rendition.

摘要翻译： 用于收集，存储和显示皮肤病图像的系统，用于监测和诊断皮肤状况和皮肤癌，包括黑素瘤。 手持单元照亮患者皮肤的一部分，并且成像装置从衍生自皮肤部分的光产生成像信号。 手持单元中的一对光输出端口布置成使得它们的强度分布以其半强度水平重叠，使得其强度的总和具有平坦的中心区域。 维护三个图像存储，一个用于损伤图像，一个用于“附近皮肤”图像，一个用于参考白色图像。 系统软件使用“附近皮肤”图像自动确定皮肤/病变边界。 参考白色图像用于设置仪器的动态范围并补偿照明不规则。 可以同时显示在不同时间拍摄的相同病变的两个图像，从而可以确定病变的变化。 校准系统的设计使得在同一规格上制造的多台机器上拍摄的图像数据将被修正为公共参考标准，以确保色彩再现的绝对准确性。

公开(公告)号：US6026323A

公开(公告)日：2000-02-15

申请号：US934152

申请日：1997-09-23

申请人： Victor Skladnev ,  Richard Thompson ,  Irwin Wunderman ,  David Bull ,  Neil Edwards ,  Stephen Rowe ,  Gregory Smart ,  Megan Smith

发明人： Victor Skladnev ,  Richard Thompson ,  Irwin Wunderman ,  David Bull ,  Neil Edwards ,  Stephen Rowe ,  Gregory Smart ,  Megan Smith

IPC分类号： A61B5/00 ,  A61B5/05 ,  A61B5/053

CPC分类号： A61B5/0538 ,  A61B5/0084 ,  A61B5/05 ,  A61B5/053 ,  A61B5/4331 ,  A61B5/7264 ,  A61B2562/085 ,  A61B5/0088 ,  A61B5/441 ,  A61B5/7203

摘要： A probe type instrument to characterize tissue type that combines optical and electrical tests in a single device capable of providing data of both types almost simultaneously from very small, e.g. 3-10 mm diameter, areas of tissue surface. Key to this approach is an instrument capable of making almost simultaneous electrical and optical measurements on the same small areas of tissue, before being moved to scan adjacent tissue areas. In the preferred operation of the system fourteen measurement cycles are performed per second and each measurement involves a complex sequence of events, including (1) three optical and fifteen electrical tissue stimulations with subsequent detection, filtering and digitization of the tissue response; (2) extraction of specific parameters from the optical and electrical signals; (3) checking for errors, and subsequent classification of the extracted parameters into various tissue type categories; and (4) feedback to the system operator. Thus on the order of 15,000 measurements are made per one minute patient examination.

摘要翻译： 用于表征组织类型的探针型仪器，其在单个装置中组合光学和电学测试，能够从非常小的例如几乎同时提供两种类型的数据。 3-10毫米直径，组织表面的区域。 该方法的关键是能够在被移动到扫描相邻组织区域之前，在组织的相同小区域上进行几乎同时的电和光学测量的仪器。 在系统的优选操作中，每秒执行十四个测量周期，每个测量涉及复杂的事件序列，包括（1）三个光学和十五个电组织刺激，随后检测，滤波和数字化组织响应; （2）从光电信号中提取具体参数; （3）检查错误，以及随后将提取的参数分类成各种组织类型类别; 和（4）反馈给系统操作员。 因此，在每一分钟的病人检查中进行15,000次测量。

公开(公告)号：US20120277723A1

公开(公告)日：2012-11-01

申请号：US13504698

申请日：2010-11-04

申请人： Victor Skladnev ,  Stanislav Tarnavskii ,  Thomas McGregor ,  Nejhdeh Ghevondian

发明人： Victor Skladnev ,  Stanislav Tarnavskii ,  Thomas McGregor ,  Nejhdeh Ghevondian

IPC分类号： A61M5/168

CPC分类号： A61B5/14532 ,  A61B5/024 ,  A61B5/4035 ,  A61B5/4839 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723

摘要： Methods and systems are described for controlling a flowrate of insulin infused into the body of a patient. An insulin infusion device infuses insulin into the body of the patient. A first sensor generates blood glucose level (BGL) data indicative of a blood glucose level of the patient. A second sensor generates autonomic nervous system (ANS) data such as heart rate data dependent on at least one parameter of the patient's autonomic nervous system. A data fusion processor receives the BGL data and the ANS data and generates an output alarm signal if a hypoglycaemic event is inferred. A flowrate of insulin of the insulin infusion device may be modified dependent on the output alarm signal.

摘要翻译： 描述了用于控制输入到患者体内的胰岛素的流量的方法和系统。 胰岛素输注装置将胰岛素注入患者体内。 第一传感器产生指示患者的血糖水平的血糖水平（BGL）数据。 第二传感器产生自主神经系统（ANS）数据，例如取决于患者自主神经系统的至少一个参数的心率数据。 如果推断出低血糖事件，则数据融合处理器接收BGL数据和ANS数据并产生输出报警信号。 胰岛素输注装置的胰岛素流量可以根据输出警报信号进行修改。

公开(公告)号：US06845264B1

公开(公告)日：2005-01-18

申请号：US09807097

申请日：1999-10-08

申请人： Victor Skladnev ,  Richard L. Thompson ,  Andrew R. Bath

发明人： Victor Skladnev ,  Richard L. Thompson ,  Andrew R. Bath

IPC分类号： A61B5/053 ,  A61B5/05

CPC分类号： A61B5/0538 ,  A61B5/0531 ,  Y10S607/901

摘要： A method and apparatus for recognizing tissue types measures at least two separate and distinct properties of a tissue specimen using a probe tip containing electrodes coupled to circuitry that applies a measuring current and obtains values of electrical properties of the tissue such as conductivity and potential difference. An algorithm then uses the values to determine the tissue's type and condition.

摘要翻译： 用于识别组织类型的方法和装置使用包含耦合到施加测量电流的电路的电极的探针尖端来测量组织样本的至少两个独立且不同的特性，并获得组织的电特性值，例如电导率和电位差。 然后，算法使用这些值来确定组织的类型和条件。

公开(公告)号：US20120220847A1

公开(公告)日：2012-08-30

申请号：US13505808

申请日：2010-11-04

申请人： Victor Skladnev ,  Stanislav Tamavskii ,  Thomas McGregor ,  Nejhdeh Ghevondian

发明人： Victor Skladnev ,  Stanislav Tamavskii ,  Thomas McGregor ,  Nejhdeh Ghevondian

IPC分类号： A61B5/024 ,  A61B5/145

CPC分类号： A61B5/024 ,  A61B5/0006 ,  A61B5/14532 ,  A61B5/7275 ,  G06F19/3418

摘要： A method and system are described for detecting a hypoglycaemic state in a patient. The patient's heart rate is monitored to provide a heart-rate signal. A time-lagged signal is determined as the difference between the heart-rate signal and a time-lagged version of the heart rate-signal. The heart-rate signal is filtered with a low-pass filter to provide a heart-rate trend. An absolute difference between the heart-rate signal and the heart-rate trend is determined to provide an absolute-difference signal. A second time-lagged signal is determined as a difference between the absolute-difference signal and a time-lagged version of the absolute-difference signal. The occurrence of a hypoglycaemic condition is inferred dependent on the time-lagged signal and the second time-lagged signal.

摘要翻译： 描述了用于检测患者中低血糖状态的方法和系统。 监测患者的心率以提供心率信号。 时间延迟信号被确定为心率信号与心率信号的时间滞后版本之间的差异。 心率信号用低通滤波器滤波以提供心率趋势。 确定心率信号与心率趋势之间的绝对差异以提供绝对差信号。 第二时滞信号被确定为绝对差信号和绝对差信号的时间滞后版本之间的差。 根据时滞信号和第二时滞信号推测出低血糖状态的发生。