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    CELLULOSE DERIVATIVES FOR INHIBITING CRYSTALLIZATION OF POORLY WATER-SOLUBLE DRUGS
    1.
    发明申请
    CELLULOSE DERIVATIVES FOR INHIBITING CRYSTALLIZATION OF POORLY WATER-SOLUBLE DRUGS 审中-公开
    用于抑制不溶性水溶性药物结晶的纤维素衍生物

    公开(公告)号：US20150004237A1

    公开(公告)日：2015-01-01

    申请号：US14368911

    申请日：2013-01-09

    Applicant: Virginia Tech Intellectual Properties, Inc. ,  Purdue Research Foundation

    Inventor： Kevin J. Edgar ,  Bin Li ,  Lynne Taylor ,  Grace Ilevbare ,  Stephanie M. Williams ,  Haoyu Liu

    IPC: A61K47/38 ,  A61K31/427 ,  A61K31/357 ,  A61K31/536 ,  A61K31/40 ,  A61K31/05 ,  C08B3/00 ,  A61K31/352

    CPC classification number: A61K47/38 ,  A61K9/146 ,  A61K31/05 ,  A61K31/352 ,  A61K31/357 ,  A61K31/40 ,  A61K31/427 ,  A61K31/536 ,  A61K31/70 ,  C08B3/00

    Abstract: Provided are cellulose esters useful for inhibiting solution crystallization of drugs. Specific polymers include cellulose esters of formula I: wherein n of the ω-carboxyalkanoyl group, is 3, 4, 6, or 8 to provide a ω-carboxyalkanoyl group chosen from succinoyl, glutaroyl, adipoyl, sebacyl, and suberyl groups; and wherein R is chosen from: a hydrogen atom; and an alkanoyl group chosen from acetyl, propionyl, butyryl, valeroyl, hexanoyl, nonanoyl, decanoyl, lauroyl, palmitoyl, and stearoyl groups; wherein there is a total degree of substitution of the alkanoyl group and the ω-carboxyalkanoyl group of at least 2.0; and wherein the polymer comprises m repeating units where n=1 to 1,000,000, or 10 to 100,000, or 100 to 1,000, such as 1 to 6,000. Embodiments further include compositions comprising cellulose esters and poorly water-soluble drugs, which compositions exhibit greater solubility and stability in solution as compared to the drugs alone.

    Abstract translation: 提供用于抑制药物溶液结晶的纤维素酯。 特定聚合物包括式I的纤维素酯：其中ω-羧基烷酰基的n为3,4,6或8，以提供选自琥珀酰基，戊二酰基，己二酰基，癸二酰基和辛二酸基的ω-羧基烷酰基; 并且其中R选自：氢原子; 和选自乙酰基，丙酰基，丁酰基，戊酰基，己酰基，壬酰基，癸酰基，月桂酰基，棕榈酰基和硬脂酰基的烷酰基; 其中烷酰基和ω-羧基烷酰基的总取代度为至少2.0; 并且其中所述聚合物包含m个重复单元，其中n = 1至1,000,000，或10至100,000，或100至1,000，如1至6,000。 实施方案还包括包含纤维素酯和水溶性差的药物的组合物，与单独的药物相比，该组合物在溶液中表现出更大的溶解度和稳定性。

    Interleaved converters with integrated magnetics
    2.
    发明授权
    Interleaved converters with integrated magnetics 有权

    公开(公告)号：US10790081B2

    公开(公告)日：2020-09-29

    申请号：US16252990

    申请日：2019-01-21

    Applicant: Virginia Tech Intellectual Properties, Inc.

    Inventor： Chao Fei ,  Bin Li ,  Fred C. Lee ,  Qiang Li ,  Hongfei Wu

    IPC: H01F27/28 ,  H01F27/24 ,  H01F27/06 ,  H02M1/15 ,  H02M3/335 ,  H02M3/158 ,  H02M7/5387 ,  H01F27/36

    Abstract: Three-phase interleaved LLC and CLLC resonant converters, with integrated magnetics, are described. In various examples, the primary sides of the phases in the converters rely upon a half-bridge configuration and include resonant networks coupled to each other in delta-connected or common Y-node configurations. The secondary sides of the phases can rely upon a full-bridge configurations and are coupled in parallel. In one example, the transformers of the phases in the converters are integrated into one magnetic core. By changing the interleaving structure between the primary and secondary windings in the transformers, resonant inductors of the phases can also be integrated into the same magnetic core. A multi-layer PCB can be used as the windings for the integrated magnetics.

    INTERLEAVED CONVERTERS WITH INTEGRATED MAGNETICS
    4.
    发明申请
    INTERLEAVED CONVERTERS WITH INTEGRATED MAGNETICS 审中-公开

    公开(公告)号：US20190355506A1

    公开(公告)日：2019-11-21

    申请号：US16252990

    申请日：2019-01-21

    Applicant: Virginia Tech Intellectual Properties, Inc.

    Inventor： Chao Fei ,  Bin Li ,  Fred C. Lee ,  Qiang Li ,  Hongfei Wu

    IPC: H01F27/28 ,  H01F27/24 ,  H01F27/06 ,  H02M1/15 ,  H01F27/36 ,  H02M3/335 ,  H02M7/5387 ,  H02M3/158

    Abstract: Three-phase interleaved LLC and CLLC resonant converters, with integrated magnetics, are described. In various examples, the primary sides of the phases in the converters rely upon a half-bridge configuration and include resonant networks coupled to each other in delta-connected or common Y-node configurations. The secondary sides of the phases can rely upon a full-bridge configurations and are coupled in parallel. In one example, the transformers of the phases in the converters are integrated into one magnetic core. By changing the interleaving structure between the primary and secondary windings in the transformers, resonant inductors of the phases can also be integrated into the same magnetic core. A multi-layer PCB can be used as the windings for the integrated magnetics.

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