公开(公告)号：US10694972B2

公开(公告)日：2020-06-30

申请号：US15536333

申请日：2015-12-15

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Rafael V. Davalos ,  Mohammad Bonakdar ,  Eduardo L. Latouche ,  Roop L. Mahajan ,  John L. Robertson ,  Christopher B. Arena ,  Michael B. Sano

IPC: A61B5/053 ,  A61B5/01 ,  G01N33/543

Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy. Provided herein are embodiments of an electrical conductivity sensor having an impedance sensor, where the impedance sensor can be configured to measure a low-frequency and a high-frequency impedance and a substrate, where the impedance sensor is coupled to the substrate. The substrate can be flexible. In embodiments, the impedance sensor can contain two or more electrical conductors. The electrical conductors can be in a bipolar configuration. The electrical conductors can be in a tetrapolar configuration. In embodiments, the electrical conductivity sensor can have two impedance sensors that can be coupled to the substrate such that they are orthogonal to each other.

公开(公告)号：US11903690B2

公开(公告)日：2024-02-20

申请号：US16865031

申请日：2020-05-01

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Rafael V. Davalos ,  Mohammad Bonakdar ,  Eduardo L. Latouche ,  Roop L. Mahajan ,  John L. Robertson ,  Christopher B. Arena ,  Michael B. Sano

IPC: A61B5/053 ,  G01N33/543 ,  A61B5/01 ,  A61B5/0538

CPC classification number: A61B5/0538 ,  A61B5/01 ,  G01N33/5438

Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.

公开(公告)号：US20200260987A1

公开(公告)日：2020-08-20

申请号：US16865031

申请日：2020-05-01

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Rafael V. Davalos ,  Mohammad Bonakdar ,  Eduardo L. Latouche ,  Roop L. Mahajan ,  John L. Robertson ,  Christopher B. Arena ,  Michael B. Sano

IPC: A61B5/053

Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.

公开(公告)号：US12269744B2

公开(公告)日：2025-04-08

申请号：US17415445

申请日：2019-12-17

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Roop L. Mahajan ,  Seul-Yi Lee

IPC: C01B32/198 ,  B01J19/14 ,  C01B32/194 ,  C01B32/196

Abstract: Methods of making graphene oxide and reduced graphene oxide are provided. The methods can include a simple one-pot synthesis of graphene oxide from a purified coal powder using a mild oxidizing acid. The methods provide for an improved, more cost-effective, and simpler process than conventional methods such as Hummers methods. In some aspects, placing the purified coal powder in the mild oxidation atmosphere includes contacting the purified coal powder with a mild oxidizing acid such as nitric acid, nitrous acid, sulfuric acid, phosphoric acid, benzoic acid, or a combination thereof. In some aspects, the mild oxidizing acid consists essentially of nitric acid. Graphene oxides and reduced graphene oxides prepared by the methods are also provided.

公开(公告)号：US20240277245A1

公开(公告)日：2024-08-22

申请号：US18404473

申请日：2024-01-04

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Rafael V. Davalos ,  Mohammad Bonakdar ,  Eduardo L. Latouche ,  Roop L. Mahajan ,  John L. Robertson ,  Christopher B. Arena ,  Michael B. Sano

IPC: A61B5/0538 ,  A61B5/01 ,  G01N33/543

CPC classification number: A61B5/0538 ,  A61B5/01 ,  G01N33/5438

Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.