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公开(公告)号：US11272979B2
公开(公告)日：2022-03-15
申请号：US16152743
申请日：2018-10-05
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Paulo A. Garcia , Christopher B. Arena , Michael B. Sano , Rafael V. Davalos
Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
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2.发明申请公开(公告)号：US20200260987A1
公开(公告)日：2020-08-20
申请号：US16865031
申请日：2020-05-01
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Mohammad Bonakdar , Eduardo L. Latouche , Roop L. Mahajan , John L. Robertson , Christopher B. Arena , Michael B. Sano
IPC: A61B5/053
Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.
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公开(公告)号：US10471254B2
公开(公告)日：2019-11-12
申请号：US15310114
申请日：2015-05-12
Applicant: Virginia Tech Intellectual Properties, Inc. , Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
IPC: A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61B18/12 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US11974800B2
公开(公告)日：2024-05-07
申请号：US16747219
申请日：2020-01-20
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Rafael V. Davalos , John L Robertson , Paulo A. Garcia , Robert E. Neal
CPC classification number: A61B18/14 , A61K48/0075 , A61M5/00 , A61B2018/00613 , A61B2018/1472 , A61B18/1492 , A61B2218/002 , A61N1/327
Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
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5.发明申请公开(公告)号：US20180125565A1
公开(公告)日：2018-05-10
申请号：US15843888
申请日：2017-12-15
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Rafael V. Davalos , John L. Robertson , Paulo A. Garcia , Robert E. Neal
Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
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Patent Agency Ranking
公开(公告)号：US11903690B2
公开(公告)日：2024-02-20
申请号：US16865031
申请日：2020-05-01
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Mohammad Bonakdar , Eduardo L. Latouche , Roop L. Mahajan , John L. Robertson , Christopher B. Arena , Michael B. Sano
IPC: A61B5/053 , G01N33/543 , A61B5/01 , A61B5/0538
CPC classification number: A61B5/0538 , A61B5/01 , G01N33/5438
Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.
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公开(公告)号：US20230248414A1
公开(公告)日：2023-08-10
申请号：US18123719
申请日：2023-03-20
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
CPC classification number: A61B18/14 , A61N1/327 , A61B2018/00761
Abstract: The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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公开(公告)号：US20220362549A1
公开(公告)日：2022-11-17
申请号：US17862486
申请日：2022-07-12
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Chirstopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US11406820B2
公开(公告)日：2022-08-09
申请号：US16520901
申请日：2019-07-24
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
IPC: A61B18/12 , A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US20220022945A9
公开(公告)日：2022-01-27
申请号：US16152743
申请日：2018-10-05
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Paulo A. Garcia , Christopher B. Arena , Michael B. Sano , Rafael V. Davalos
IPC: A61B18/14
Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
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