公开(公告)号：US07794753B2

公开(公告)日：2010-09-14

申请号：US10402151

申请日：2003-03-31

申请人： Vishwa Nath Gupta ,  Krishan Avtar Suri ,  Bishan Datt Gupta ,  Bupinder Singh Jaggi ,  Naresh Kumar Satti ,  Bal Krishan Chandan ,  Neelam Sharma ,  Vikram Bhardwaj ,  Om Parkash Suri ,  Ghulam Nabi Qazi ,  Jyotsna Suri ,  Madalsa Bargotra

发明人： Vishwa Nath Gupta ,  Krishan Avtar Suri ,  Bishan Datt Gupta ,  Bupinder Singh Jaggi ,  Naresh Kumar Satti ,  Bal Krishan Chandan ,  Neelam Sharma ,  Vikram Bhardwaj ,  Om Parkash Suri ,  Ghulam Nabi Qazi ,  Jyotsna Suri ,  Madalsa Bargotra

IPC分类号： A61K9/14 ,  A61K31/20

CPC分类号： A61K31/20 ,  A61K9/141 ,  A61K31/365 ,  A61K2300/00

摘要： The present invention relates to a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) in the ratio ranging between 1:7 to 7:1 (w/w), useful in hepatoprotection; and a process for the preparation of a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) useful in hepatoprotection, said process comprising steps of grounding the particles of the t-TCA and AP into fine particles, mixing the fine particles in ratio ranging between 1:7 to 7:1 (w/w), and grinding the mixture to obtain formulation, and also, a method of hepatoprotection of a subject using the synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP), said method comprising the steps of administering the formulation to the subject.

摘要翻译： 本发明涉及包含反式二十四碳-15-辛酸（t-TCA）和穿心莲内酯（AP）的协同制剂，其比例范围为1:7至7:1（w / w），可用于肝保护; 以及用于制备包含可用于肝保护的反式二十四碳-15-辛酸（t-TCA）和穿心莲内酯（AP））的协同制剂的方法，所述方法包括以下步骤：将t-TCA和AP的颗粒接合到细 颗粒，以1:7至7:1（w / w）的比例混合细颗粒，并研磨混合物以获得制剂，以及使用包含反式二十四烷酸的协同制剂对受试者进行肝保护的方法， 15-辛酸（t-TCA）和穿心莲内酯（AP），所述方法包括以下步骤：将该制剂给予受试者。

公开(公告)号：US06989162B2

公开(公告)日：2006-01-24

申请号：US10403700

申请日：2003-03-31

申请人： Ghulam Nabi Qazi ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Krishan Avtar Suri ,  Bishan Datt Gupta ,  Bupinder Singh Jaggi ,  Bal Krishan Kapahi ,  Naresh Kumar Satti ,  Musarat Amina ,  Bal Krishan Chandan ,  Neelam Sharma ,  Gurdarshan Singh

发明人： Ghulam Nabi Qazi ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Krishan Avtar Suri ,  Bishan Datt Gupta ,  Bupinder Singh Jaggi ,  Bal Krishan Kapahi ,  Naresh Kumar Satti ,  Musarat Amina ,  Bal Krishan Chandan ,  Neelam Sharma ,  Gurdarshan Singh

IPC分类号： A61K35/78 ,  A61K31/70 ,  A61K31/33 ,  A61K31/555 ,  A61K31/05

CPC分类号： A61K36/53 ,  Y10S514/893

摘要： A process of isolation of pure Acteoside of high hepatoprotection from plant Colerbrookea oppositifolia, said process comprising steps of drying aerial parts of the plant, grounding the dried parts into powder, percolating the powder with water or ethanol for 3-4 times to obtain an extract, filtering the extract for clearing of suspended particles to obtain supernatant, drying the supernatant at about 45 to 55° C. to obtain a residue, fractionating the residue with chloroform, ethyl acetate, and butanol successively, subjecting butanol fraction to adsorption chromatography of SiO2 after adding methanol to the fraction, charging the adsorbed fraction to glass column, eluting the column with solvents of increasing polarity of methanol:chloroform to obtain further fractions and repeating the process one more time, subjecting the fractions to column chromatography to obtain fractions, concentrating the fractions under reduced pressure to obtain acteoside as residue; and a method of effectively hepatoprotecting a subject using pure Acteoside from plant Colerbrookea oppositifolia, said method comprising steps of administering appropriate low-dose of the acteoside to the subject.

摘要翻译： 从植物Colerbrookea oppositifolia中分离出高保护酶的纯Acteoside的过程，所述方法包括干燥植物的地上部分，将干燥部分粉碎成粉末，用水或乙醇渗滤粉末3-4次以获得提取物 过滤提取物以清除悬浮颗粒以获得上清液，在约45至55℃下干燥上清液，得到残余物，依次用氯仿，乙酸乙酯和丁醇分馏残余物，将丁醇级分进行吸附层析 在将甲醇加入到级分中后，将吸附的级分装入玻璃柱，用极性升高的甲醇：氯仿溶剂洗脱柱，得到更多的级分并重复该过程一次， 进行柱色谱分离，得到级分，减压浓缩，得到作为残留物的acteoside; 该方法包括以下步骤：向受试者施用合适的低剂量的acteoside。

公开(公告)号：US07259148B2

公开(公告)日：2007-08-21

申请号：US10436321

申请日：2003-05-12

申请人： Anil Prabhakar ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Swadesh Malhotra ,  Kuldip Kumar Gupta ,  Vijay Kumar Sharma ,  Rakesh Kamal Johri ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Shankar Lal ,  Kasturi Lal Bedi ,  Om Parkash Suri ,  Gulam Nabi Qazi

发明人： Anil Prabhakar ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Swadesh Malhotra ,  Kuldip Kumar Gupta ,  Vijay Kumar Sharma ,  Rakesh Kamal Johri ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Shankar Lal ,  Kasturi Lal Bedi ,  Om Parkash Suri ,  Gulam Nabi Qazi

IPC分类号： A61K31/70

CPC分类号： A61K31/704 ,  A61K36/85 ,  Y02A50/463

摘要： The present invention provides a method for treating and/or preventing hepatic disease conditions in a subject mammals including human beings, said method comprising the steps of administering to the mammal an effective dosage of composition comprising 2′-p-Hydroxy benzoyl mussaenosidic acid from plant Vitex negundo optionally as individual or in combination with one or more pharmaceutically additives.

摘要翻译： 本发明提供了治疗和/或预防包括人在内的受试哺乳动物的肝病状况的方法，所述方法包括以下步骤：给予哺乳动物有效剂量的组合物，其包含来自植物的2'-对羟基苯甲酰基马来西亚酸 Vitex negundo任选地作为个体或与一种或多种药学添加剂组合。

公开(公告)号：US06913772B2

公开(公告)日：2005-07-05

申请号：US10735437

申请日：2003-12-11

申请人： Ghulam Nabi Qazi ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Rakesh Maurya ,  Lila Ram Manhas ,  Ashwani Kumar ,  Bal Krishan Kapahi

发明人： Ghulam Nabi Qazi ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Rakesh Maurya ,  Lila Ram Manhas ,  Ashwani Kumar ,  Bal Krishan Kapahi

IPC分类号： A01N25/00 ,  A01N27/00 ,  A01N65/00 ,  A61K31/4745 ,  A61K31/70 ,  A61K36/27 ,  A61K35/78

CPC分类号： A61K36/27 ,  Y10S514/885 ,  Y10S514/893 ,  Y10S514/894

摘要： The present invention relates to a composition useful for hepatoprotection, said composition comprising polar extract of plant Cryptolepis Buchanani and/or fractions of the said extract, and optionally pharmaceutically acceptable additives and a method of producing said composition and also a method of treating a subject using said composition.

摘要翻译： 本发明涉及一种可用于肝保护的组合物，所述组合物包含植物Cryptolepis Buchanani的极性提取物和/或所述提取物的级分，和任选的药学上可接受的添加剂和制备所述组合物的方法，以及使用 所说的组合。

公开(公告)号：US06686375B2

公开(公告)日：2004-02-03

申请号：US10107671

申请日：2002-03-26

申请人： Ghulam Nabi Qazi ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Krishnan Avtar Suri ,  Naresh Kumar Satti ,  Rakesh Maurya ,  Lila Ram Manhas ,  Ashwani Kumar ,  Bal Krishnan Kapahi

发明人： Ghulam Nabi Qazi ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Krishnan Avtar Suri ,  Naresh Kumar Satti ,  Rakesh Maurya ,  Lila Ram Manhas ,  Ashwani Kumar ,  Bal Krishnan Kapahi

IPC分类号： A61K3578

CPC分类号： A61K36/27 ,  Y10S514/885 ,  Y10S514/893 ,  Y10S514/894

摘要： The present invention relates to a composition useful for hepatoprotection, said composition comprising polar extract of plant Cryptolepis Buchanani and/or fractions of the said extract, and optionally pharmaceutically acceptable additives and a method of producing said composition and also a method of treating a subject using said composition.

摘要翻译： 本发明涉及可用于肝保护的组合物，所述组合物包含植物Cryptolepis Buchanani的极性提取物和/或所述提取物的级分，以及任选的药学上可接受的添加剂以及制备所述组合物的方法，以及使用 所说的组合。

公开(公告)号：US06664236B2

公开(公告)日：2003-12-16

申请号：US10100166

申请日：2002-03-19

申请人： J. L. Suri ,  S. K. Banerjee ,  Subhash Chandra Taneja ,  A. S. Anand ,  Anil Prabhakar ,  Bupinder Singh Jaggi ,  A. K. Saxena ,  Bal Krishan Chandan ,  Sukhdev Swami Handa

发明人： J. L. Suri ,  S. K. Banerjee ,  Subhash Chandra Taneja ,  A. S. Anand ,  Anil Prabhakar ,  Bupinder Singh Jaggi ,  A. K. Saxena ,  Bal Krishan Chandan ,  Sukhdev Swami Handa

IPC分类号： A01N6500

CPC分类号： A61K36/19 ,  A61K2300/00

摘要： The present invention provides a synergistic composition of bioactive fraction essentially constituting iridoid glucosides, acetyl barlerin and shanzhiside methyl ester isolated from a plant source Barleria prionitis linn along with a process for the isolation of the bioactive fraction, the present invention also relates to a method of treating mammals and humans for hepatotoxicity, stress and immuno-deficiency with the synergistic bioactive composition.

摘要翻译： 本发明提供了生物活性部分的协同组合物，其基本上构成了从植物来源的Barleria prionitis linn分离的环烯醚萜苷，乙酰大肠杆菌素和shanzhiside甲酯以及分离生物活性级分的方法，本发明还涉及一种方法 用协同生物活性组合物治疗哺乳动物和人类的肝毒性，应激和免疫缺陷。