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公开(公告)号：US06852759B2
公开(公告)日：2005-02-08
申请号：US10113220
申请日：2002-03-28
申请人： Vishwa Nath Gupta , Vikram Bhardwaj , Bhupinder Singh , Bal Krishan Chandan , Krishan Avtar Suri , Naresh Kumar Satti , Om Parkash Suri , Sukhdev Swami Handa
发明人： Vishwa Nath Gupta , Vikram Bhardwaj , Bhupinder Singh , Bal Krishan Chandan , Krishan Avtar Suri , Naresh Kumar Satti , Om Parkash Suri , Sukhdev Swami Handa
摘要： The present invention relates to a process for the preparation of trans-alkenoic acids of general formula CH3—(CH2)n—CH═(CH2)mCO2H where n=4 to 9 m=8 to 16. More particularly, the present invention relates to a process for the preparation of trans-tetracos-15-enoic acid, which is a bioactive constituent possessing dose-related hepatoprotective activity. The present invention also relates to the use thereof for hepatoprotection.
摘要翻译： 本发明涉及一种制备通式CH 3 - （CH 2）n -CH =（CH 2）m CO 2 H的反式链烯酸的方法，其中n = 4〜9μm= 8〜16。更具体地说，本发明涉及 涉及制备具有剂量相关性肝保护活性的生物活性成分的反式二十四碳烯酸的方法。 本发明还涉及其用于肝保护的用途。
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2.发明授权Synergistic composition of trans-tetracos-15-enoic acid and Apocynin and method of treatment for hepatotoxicity 有权反式二十四碳-15-酸和助播胶的协同组成及其肝毒性治疗方法公开(公告)号：US06949586B2
公开(公告)日：2005-09-27
申请号：US10102147
申请日：2002-03-20
申请人： Sukhdev Swami Handa , Om Parkash Suri , Vishwa Nath Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Vikram Bhardwaj , Bupinder Singh , Bal Krishan Chandan
发明人： Sukhdev Swami Handa , Om Parkash Suri , Vishwa Nath Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Vikram Bhardwaj , Bupinder Singh , Bal Krishan Chandan
CPC分类号： A61K36/24 , A61K36/48 , A61K2300/00
摘要： The present invention relates to a synergistic hepatoprotective pharmaceutical composition comprising an effective amount of trans-tetracos-15-enoic acid (TCA) and Apocynin (APO), the present invention also relates to a method of treatment for hepatotoxicity in mammals and humans.
摘要翻译： 本发明涉及包含有效量的反式二十四碳-15-辛酸（TCA）和阿扑炔（APO））的协同肝保护药物组合物，本发明还涉及一种治疗哺乳动物和人类肝毒性的方法。
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公开(公告)号：US07118766B2
公开(公告)日：2006-10-10
申请号：US10073548
申请日：2002-02-11
申请人： Sukhdev Swami Handa , Bupinder Singh , Bal Krishan Chandan , Ajit Kumar Saxena , Vikram Bhardwaj , V. N. Gupta , Om Parkash Suri , Naresh Kumar Satti , Krishan Avtar Suri
发明人： Sukhdev Swami Handa , Bupinder Singh , Bal Krishan Chandan , Ajit Kumar Saxena , Vikram Bhardwaj , V. N. Gupta , Om Parkash Suri , Naresh Kumar Satti , Krishan Avtar Suri
IPC分类号： A01N65/00
CPC分类号： A61K36/24 , A61K36/48 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising a bioactive constituent trans-tetracos-15-enoic acid and a process for the isolation of tetracos-15-enoic acid from the plant Indigofera tinctoria along with a method of treatment for hepatotoxicity.
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公开(公告)号：US06670459B2
公开(公告)日：2003-12-30
申请号：US10103633
申请日：2002-03-20
申请人： Sukhdev Swami Handa , Om Prakash Suri , Vishwa Nath Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Vikram Bhardwaj , Kasturi Lal Bedi , Anamika Khajuria , Anpurna Kaul , Girish G. Parikh , Prabhakar Kulhar , Ulhas Salunkhe , Raman Krishnamurthy
发明人： Sukhdev Swami Handa , Om Prakash Suri , Vishwa Nath Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Vikram Bhardwaj , Kasturi Lal Bedi , Anamika Khajuria , Anpurna Kaul , Girish G. Parikh , Prabhakar Kulhar , Ulhas Salunkhe , Raman Krishnamurthy
IPC分类号： C07H1524
CPC分类号： C07J17/00
摘要： The present invention relates to a process for the isolation of a novel oligospirostanoside structurally constructed as 3-0-[&agr;-L-rhamnopyranosyl-(1→2)-&agr;-L-rhamnopyranosyl-(1→4)-0-&bgr;-D-glucopyranosyl]-25(S)-5&bgr; spirostan-3&bgr;-ol isolated from Asparagus racemosus and biologically evaluated as a potent immunomodulatory agent.
摘要翻译： 本发明涉及一种分离新结构构建为3-0- [α-L-鼠李糖吡喃糖基 - （1-> 2）-alpha-L-鼠李糖吡喃糖基 - （1-> 4）-O- 从Asparagus racemosus分离的β-D-吡喃葡萄糖基] -25（S）-5β螺甾烷-3β-醇，并被生物学评价为有效的免疫调节剂。
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5.发明授权Oligospirostanoside, pharmaceutical composition containing novel oligospirostanoside and method for immunomodulation using said oligospirostanoside 有权寡氟烷基苷，包含新型寡螺甾烷基苷的药物组合物和使用所述寡螺甾烷基糖苷的免疫调节方法公开(公告)号：US06649745B2
公开(公告)日：2003-11-18
申请号：US10103644
申请日：2002-03-20
申请人： Sukhdev Swami Handa , Om Prakash Suri , Vishwa Nath Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Vikram Bhardwaj , Kasturi Lal Bedi , Anamika Khajuria , Anpurna Kaul , Girish G. Parikh , Prabhakar Kulhar , Ulhas Salunkhe , Raman Krishnamurthy
发明人： Sukhdev Swami Handa , Om Prakash Suri , Vishwa Nath Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Vikram Bhardwaj , Kasturi Lal Bedi , Anamika Khajuria , Anpurna Kaul , Girish G. Parikh , Prabhakar Kulhar , Ulhas Salunkhe , Raman Krishnamurthy
IPC分类号： C07C1328
CPC分类号： A61K31/7048 , C07J17/00
摘要： The present invention relates to a novel oligospirostanoside having the structure 3-0-[&agr;-L-rhamnopyranosyl-(1→2)-&agr;-L-rhamnopyranosyl-(1→4)-0-&bgr;-D-glucopyranosyl]-25(S)-5&bgr;-spirostan-3&bgr;-ol isolated from Asparagus racemosus and to a pharmaceutical composition containing the novel oligospirostanoside and to a method for immunomodulation using said oligospirostanoside by administering a pharmaceutically effective amount of said novel oligospirostanoside.
摘要翻译： 本发明涉及具有3-0- [α-L-鼠李糖吡喃糖基 - （1-> 2）-alpha-L-鼠李糖吡喃糖基 - （1-> 4）-β-D-吡喃葡萄糖基]结构的新型寡螺甾烷基苷， 从日本芦笋分离的-25（S）-5β-螺甾烷-3β-醇，以及含有该新型寡螺甾烷酸苷的药物组合物，以及使用所述寡螺甾烷基苷的免疫调节方法，通过施用药学上有效量的所述新型低聚螺旋状甙。
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6.发明授权Synergistic composition of bioactive fraction isolated from barleria prionitis linn and a method of treatment for hepatotoxicity, immuno-deficiency and fatigue and a process thereof 失效从barperia prionitis linn分离的生物活性成分的协同组成和肝毒性，免疫缺陷和疲劳的治疗方法及其过程公开(公告)号：US06664236B2
公开(公告)日：2003-12-16
申请号：US10100166
申请日：2002-03-19
申请人： J. L. Suri , S. K. Banerjee , Subhash Chandra Taneja , A. S. Anand , Anil Prabhakar , Bupinder Singh Jaggi , A. K. Saxena , Bal Krishan Chandan , Sukhdev Swami Handa
发明人： J. L. Suri , S. K. Banerjee , Subhash Chandra Taneja , A. S. Anand , Anil Prabhakar , Bupinder Singh Jaggi , A. K. Saxena , Bal Krishan Chandan , Sukhdev Swami Handa
IPC分类号： A01N6500
CPC分类号： A61K36/19 , A61K2300/00
摘要： The present invention provides a synergistic composition of bioactive fraction essentially constituting iridoid glucosides, acetyl barlerin and shanzhiside methyl ester isolated from a plant source Barleria prionitis linn along with a process for the isolation of the bioactive fraction, the present invention also relates to a method of treating mammals and humans for hepatotoxicity, stress and immuno-deficiency with the synergistic bioactive composition.
摘要翻译： 本发明提供了生物活性部分的协同组合物，其基本上构成了从植物来源的Barleria prionitis linn分离的环烯醚萜苷，乙酰大肠杆菌素和shanzhiside甲酯以及分离生物活性级分的方法，本发明还涉及一种方法 用协同生物活性组合物治疗哺乳动物和人类的肝毒性，应激和免疫缺陷。
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7.发明授权Glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof 失效吡喃葡萄糖苷，其分离方法，含有其的药物组合物及其用途公开(公告)号：US06562791B1
公开(公告)日：2003-05-13
申请号：US10112229
申请日：2002-03-29
IPC分类号： A61K317042
CPC分类号： C07H7/06 , Y10S514/866
摘要： A novel glucopyranoside, 6-hydroxy-2-p-hydroxybenzylbenzofuran-7-C-&bgr;-D-glucopyranoside of the formula 1 isolated from Pterocarpus marsupium and to a process for the isolation thereof is disclosed. The invention also relates to a pharmaceutical composition containing 6-hydroxy-2-p-hydroxybenzylbenzofuran-7-C-&bgr;-D-glucopyranoside and to method for the treatment of diabetes using said compound.
摘要翻译： 公开了一种新颖的吡喃葡萄糖苷，由Pterocarpus marsupium分离的式1的6-羟基-2-对羟基苄基苯并呋喃-7-C-β-D-吡喃葡萄糖苷及其分离方法。 本发明还涉及含有6-羟基-2-对羟基苄基苯并呋喃-7-C-β-D-吡喃葡萄糖苷的药物组合物和使用所述化合物治疗糖尿病的方法。
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公开(公告)号：US07057040B2
公开(公告)日：2006-06-06
申请号：US10067546
申请日：2002-02-07
IPC分类号： C07D295/192
CPC分类号： C07D295/185 , A23L27/205 , C07D311/58 , C07D319/18
摘要： The present invention relates to novel compounds possessing specific hot, pungent and spicy taste when subjected to direct pungency evaluation, which may be useful as food additives and anti-oxidants, however the said compounds do not add to any nutritional value but the synthesised compounds can possess useful pharmacological properties which is expected to find application in new test models for the development of anti-inflammatory drugs, bioavailability enhancers and for the study of hepatic drug metabolising mechanism; also relates to a process for preparing the said compounds.
摘要翻译： 本发明涉及当经受直接刺激性评估时具有特别热，刺鼻和辛辣味道的新化合物，其可用作食品添加剂和抗氧化剂，然而所述化合物不增加任何营养价值，但合成的化合物可以 具有有用的药理学性质，预计可用于新型抗炎药，生物利用度增强剂研发试验和肝脏药物代谢机制研究; 还涉及制备所述化合物的方法。
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9.发明授权Method of treating diabetes using plant argyrolobium roseum extract, and a process for the isolation of extract from the said plant 有权使用植物蔷薇提取物治疗糖尿病的方法，以及从所述植物中分离提取物的方法公开(公告)号：US06869625B2
公开(公告)日：2005-03-22
申请号：US10267040
申请日：2002-10-09
IPC分类号： A01N25/00 , A61K20060101 , A61K36/48 , A61P20060101 , A61P3/10 , A61K35/78
CPC分类号： A61K36/48 , Y10S514/866
摘要： The present invention relates to a process for isolating plant Argyrobium roseum extract that contains flavonoid glycoside, wherein the extract possesses hypoglycaemic activity. The present invention also contemplates a composition containing the extract and a method of treating various hyperglycaemic conditions including non-insulin dependent diabetes mellitus disease condition by administering the extract.
摘要翻译： 本发明涉及一种分离含有黄酮糖苷的植物蔷薇提取物的方法，其中提取物具有低血糖活性。 本发明还考虑了包含提取物的组合物和通过施用该提取物来治疗各种高血糖病症包括非胰岛素依赖型糖尿病疾病的方法。
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公开(公告)号：US06977294B2
公开(公告)日：2005-12-20
申请号：US10099292
申请日：2002-03-13
IPC分类号： A61K31/7048 , A61K36/18 , A61P5/20 , A61P19/10 , C07H1/08 , C07H17/07 , C07H17/00 , A61K35/78
摘要： The present invention relates to a process of isolation of bioactive eupalitin (3-O-O-D-galactopyranoside) of formula 1 possessing anti-osteoporosis activity by extraction of powdered leaves of Boerhaavia diffusa, with better yield:
摘要翻译： 本发明涉及通过提取Boerhaavia diffusa的粉末叶分离具有抗骨质疏松活性的式1的生物活性eupalitin（3-O-O-吡喃半乳糖苷）的方法，其产率更高：
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