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    Substituted aryl alkenoic acid heterocyclic amides
    1.
    发明授权
    Substituted aryl alkenoic acid heterocyclic amides 有权
    取代的芳基烯酸杂环酰胺

    公开(公告)号：US07057040B2

    公开(公告)日：2006-06-06

    申请号：US10067546

    申请日：2002-02-07

    申请人： Subhash Chandra Taneja ,  Surrinder Koul ,  Jawahir Lal Koul ,  Beenu Moza ,  Sukhdev Swami Handa

    发明人： Subhash Chandra Taneja ,  Surrinder Koul ,  Jawahir Lal Koul ,  Beenu Moza ,  Sukhdev Swami Handa

    IPC分类号： C07D295/192

    CPC分类号： C07D295/185 ,  A23L27/205 ,  C07D311/58 ,  C07D319/18

    摘要： The present invention relates to novel compounds possessing specific hot, pungent and spicy taste when subjected to direct pungency evaluation, which may be useful as food additives and anti-oxidants, however the said compounds do not add to any nutritional value but the synthesised compounds can possess useful pharmacological properties which is expected to find application in new test models for the development of anti-inflammatory drugs, bioavailability enhancers and for the study of hepatic drug metabolising mechanism; also relates to a process for preparing the said compounds.

    摘要翻译： 本发明涉及当经受直接刺激性评估时具有特别热，刺鼻和辛辣味道的新化合物，其可用作食品添加剂和抗氧化剂，然而所述化合物不增加任何营养价值，但合成的化合物可以 具有有用的药理学性质，预计可用于新型抗炎药，生物利用度增强剂研发试验和肝脏药物代谢机制研究; 还涉及制备所述化合物的方法。

    Substituted aryl alkenoic acid heterocyclic amides
    2.
    发明授权
    Substituted aryl alkenoic acid heterocyclic amides 有权
    取代的芳基烯酸杂环酰胺

    公开(公告)号：US07262296B2

    公开(公告)日：2007-08-28

    申请号：US11300295

    申请日：2005-12-15

    申请人： Subhash Chandra Taneja ,  Surrinder Koul ,  Jawahir Lal Koul ,  Beenu Moza ,  Sukhdev Swami Handa

    发明人： Subhash Chandra Taneja ,  Surrinder Koul ,  Jawahir Lal Koul ,  Beenu Moza ,  Sukhdev Swami Handa

    IPC分类号： C07D295/192 ,  C07D265/30

    CPC分类号： C07D295/185 ,  A23L27/205 ,  C07D311/58 ,  C07D319/18

    摘要： The present invention relates to novel compounds possessing specific hot, pungent and spicy taste when subjected to direct pungency evaluation, which may be useful as food additives and anti-oxidants, however the said compounds do not add to any nutritional value but the synthesised compounds can possess useful pharmacological properties which is expected to find application in new test models for the development of anti-inflammatory drugs, bioavailability enhancers and for the study of hepatic drug metabolising mechanism; also relates to a process for preparing the said compounds.

    摘要翻译： 本发明涉及当经受直接刺激性评估时具有特别热，刺鼻和辛辣味道的新化合物，其可用作食品添加剂和抗氧化剂，然而所述化合物不增加任何营养价值，但合成的化合物可以 具有有用的药理学性质，预计可用于新型抗炎药，生物利用度增强剂研发试验和肝脏药物代谢机制研究; 还涉及制备所述化合物的方法。

    Trichosporon sp RRLY-15 (DSM 11829) and its use to prepare S(+)-6-methoxy-methyl-2-naphthalene acetic acid
    4.
    发明授权
    Trichosporon sp RRLY-15 (DSM 11829) and its use to prepare S(+)-6-methoxy-methyl-2-naphthalene acetic acid 失效
    Trichosporon sp RRLY-15（DSM 11829）及其用于制备S（+） - 6-甲氧基 - 甲基-2-萘乙酸

    公开(公告)号：US06242243B1

    公开(公告)日：2001-06-05

    申请号：US09050011

    申请日：1998-03-30

    申请人： Ghulam Nabi Qazi ,  Rajinder Parshad ,  Surrinder Koul ,  Subhash Chandra Taneja ,  Kanaya Lal Dhar ,  Ravi Ji Kotru ,  Sukhdev Swami Handa

    发明人： Ghulam Nabi Qazi ,  Rajinder Parshad ,  Surrinder Koul ,  Subhash Chandra Taneja ,  Kanaya Lal Dhar ,  Ravi Ji Kotru ,  Sukhdev Swami Handa

    IPC分类号： C12N118

    CPC分类号： C12R1/645 ,  C12P41/002 ,  Y10S435/911

    摘要： This invention discloses a process for the use of a novel organism belonging to the genus Trichosporon sp. as whole wet or dry cell culture or cell free extract or crude enzyme or pure isolated enzyme The strain of Trichosporon sp. used in the process is designated as RRLY-15 and has been deposited in Deutsche Sammlung von Mikroorganismen und Zellekulturen GmbH (DSMZ). The invention also discloses the preparation of S(+)-6-methoxy-2-naphthalene acetic acid (naproxen) of formula (2) through enantioselective hydrolysis of a racemic mixture of alkyl esters of (±)-6-methoxy-&agr;-methyl-2-naphthalene acetic acid of formula (1) where R represents —CH3,—C2H5,—C3H7,—C4H9 and the like and S(+)- Naproxen is a medicinally important non steroidal anti-inflammatory drug.

    摘要翻译： 本发明公开了一种使用属于Trichosporon sp。的新生物的方法。 作为整个湿或干细胞培养或无细胞提取物或粗酶或纯分离的酶Trichosporon sp。 在该过程中使用的产品被指定为RRLY-15，并已存放在德意志银行（Mikroorganismen und Zellekulturen GmbH）（DSMZ）。 本发明还公开了通过对映选择性水解（±）-6-甲氧基-α-甲氧基-2-甲基苯基的烷基酯的外消旋混合物制备式（2）的S（+） - 6-甲氧基-2-萘乙酸（萘普生） 式（1）的甲基-2-萘乙酸，其中R表示-CH 3，-C 2 H 5，-C 3 H 7，-C 4 H 9等，而S（+） - 萘普生是药物重要的非甾体抗炎药。