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公开(公告)号：US06852759B2
公开(公告)日：2005-02-08
申请号：US10113220
申请日：2002-03-28
申请人： Vishwa Nath Gupta , Vikram Bhardwaj , Bhupinder Singh , Bal Krishan Chandan , Krishan Avtar Suri , Naresh Kumar Satti , Om Parkash Suri , Sukhdev Swami Handa
发明人： Vishwa Nath Gupta , Vikram Bhardwaj , Bhupinder Singh , Bal Krishan Chandan , Krishan Avtar Suri , Naresh Kumar Satti , Om Parkash Suri , Sukhdev Swami Handa
摘要： The present invention relates to a process for the preparation of trans-alkenoic acids of general formula CH3—(CH2)n—CH═(CH2)mCO2H where n=4 to 9 m=8 to 16. More particularly, the present invention relates to a process for the preparation of trans-tetracos-15-enoic acid, which is a bioactive constituent possessing dose-related hepatoprotective activity. The present invention also relates to the use thereof for hepatoprotection.
摘要翻译： 本发明涉及一种制备通式CH 3 - （CH 2）n -CH =（CH 2）m CO 2 H的反式链烯酸的方法，其中n = 4〜9μm= 8〜16。更具体地说，本发明涉及 涉及制备具有剂量相关性肝保护活性的生物活性成分的反式二十四碳烯酸的方法。 本发明还涉及其用于肝保护的用途。
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2.发明授权Synergistic composition of trans-tetracos-15-enoic acid and Apocynin and method of treatment for hepatotoxicity 有权反式二十四碳-15-酸和助播胶的协同组成及其肝毒性治疗方法公开(公告)号：US06949586B2
公开(公告)日：2005-09-27
申请号：US10102147
申请日：2002-03-20
申请人： Sukhdev Swami Handa , Om Parkash Suri , Vishwa Nath Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Vikram Bhardwaj , Bupinder Singh , Bal Krishan Chandan
发明人： Sukhdev Swami Handa , Om Parkash Suri , Vishwa Nath Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Vikram Bhardwaj , Bupinder Singh , Bal Krishan Chandan
CPC分类号： A61K36/24 , A61K36/48 , A61K2300/00
摘要： The present invention relates to a synergistic hepatoprotective pharmaceutical composition comprising an effective amount of trans-tetracos-15-enoic acid (TCA) and Apocynin (APO), the present invention also relates to a method of treatment for hepatotoxicity in mammals and humans.
摘要翻译： 本发明涉及包含有效量的反式二十四碳-15-辛酸（TCA）和阿扑炔（APO））的协同肝保护药物组合物，本发明还涉及一种治疗哺乳动物和人类肝毒性的方法。
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公开(公告)号：US07118766B2
公开(公告)日：2006-10-10
申请号：US10073548
申请日：2002-02-11
申请人： Sukhdev Swami Handa , Bupinder Singh , Bal Krishan Chandan , Ajit Kumar Saxena , Vikram Bhardwaj , V. N. Gupta , Om Parkash Suri , Naresh Kumar Satti , Krishan Avtar Suri
发明人： Sukhdev Swami Handa , Bupinder Singh , Bal Krishan Chandan , Ajit Kumar Saxena , Vikram Bhardwaj , V. N. Gupta , Om Parkash Suri , Naresh Kumar Satti , Krishan Avtar Suri
IPC分类号： A01N65/00
CPC分类号： A61K36/24 , A61K36/48 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition comprising a bioactive constituent trans-tetracos-15-enoic acid and a process for the isolation of tetracos-15-enoic acid from the plant Indigofera tinctoria along with a method of treatment for hepatotoxicity.
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公开(公告)号：US07794753B2
公开(公告)日：2010-09-14
申请号：US10402151
申请日：2003-03-31
申请人： Vishwa Nath Gupta , Krishan Avtar Suri , Bishan Datt Gupta , Bupinder Singh Jaggi , Naresh Kumar Satti , Bal Krishan Chandan , Neelam Sharma , Vikram Bhardwaj , Om Parkash Suri , Ghulam Nabi Qazi , Jyotsna Suri , Madalsa Bargotra
发明人： Vishwa Nath Gupta , Krishan Avtar Suri , Bishan Datt Gupta , Bupinder Singh Jaggi , Naresh Kumar Satti , Bal Krishan Chandan , Neelam Sharma , Vikram Bhardwaj , Om Parkash Suri , Ghulam Nabi Qazi , Jyotsna Suri , Madalsa Bargotra
CPC分类号： A61K31/20 , A61K9/141 , A61K31/365 , A61K2300/00
摘要： The present invention relates to a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) in the ratio ranging between 1:7 to 7:1 (w/w), useful in hepatoprotection; and a process for the preparation of a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) useful in hepatoprotection, said process comprising steps of grounding the particles of the t-TCA and AP into fine particles, mixing the fine particles in ratio ranging between 1:7 to 7:1 (w/w), and grinding the mixture to obtain formulation, and also, a method of hepatoprotection of a subject using the synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP), said method comprising the steps of administering the formulation to the subject.
摘要翻译： 本发明涉及包含反式二十四碳-15-辛酸（t-TCA）和穿心莲内酯（AP）的协同制剂，其比例范围为1:7至7:1（w / w），可用于肝保护; 以及用于制备包含可用于肝保护的反式二十四碳-15-辛酸（t-TCA）和穿心莲内酯（AP））的协同制剂的方法，所述方法包括以下步骤：将t-TCA和AP的颗粒接合到细 颗粒，以1:7至7:1（w / w）的比例混合细颗粒，并研磨混合物以获得制剂，以及使用包含反式二十四烷酸的协同制剂对受试者进行肝保护的方法， 15-辛酸（t-TCA）和穿心莲内酯（AP），所述方法包括以下步骤：将该制剂给予受试者。
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公开(公告)号：US07259148B2
公开(公告)日：2007-08-21
申请号：US10436321
申请日：2003-05-12
申请人： Anil Prabhakar , Bishan Datt Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Swadesh Malhotra , Kuldip Kumar Gupta , Vijay Kumar Sharma , Rakesh Kamal Johri , Bupinder Singh Jaggi , Bal Krishan Chandan , Shankar Lal , Kasturi Lal Bedi , Om Parkash Suri , Gulam Nabi Qazi
发明人： Anil Prabhakar , Bishan Datt Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Swadesh Malhotra , Kuldip Kumar Gupta , Vijay Kumar Sharma , Rakesh Kamal Johri , Bupinder Singh Jaggi , Bal Krishan Chandan , Shankar Lal , Kasturi Lal Bedi , Om Parkash Suri , Gulam Nabi Qazi
IPC分类号： A61K31/70
CPC分类号： A61K31/704 , A61K36/85 , Y02A50/463
摘要： The present invention provides a method for treating and/or preventing hepatic disease conditions in a subject mammals including human beings, said method comprising the steps of administering to the mammal an effective dosage of composition comprising 2′-p-Hydroxy benzoyl mussaenosidic acid from plant Vitex negundo optionally as individual or in combination with one or more pharmaceutically additives.
摘要翻译： 本发明提供了治疗和/或预防包括人在内的受试哺乳动物的肝病状况的方法，所述方法包括以下步骤：给予哺乳动物有效剂量的组合物，其包含来自植物的2'-对羟基苯甲酰基马来西亚酸 Vitex negundo任选地作为个体或与一种或多种药学添加剂组合。
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公开(公告)号：US06989162B2
公开(公告)日：2006-01-24
申请号：US10403700
申请日：2003-03-31
申请人： Ghulam Nabi Qazi , Om Parkash Suri , Kasturi Lal Bedi , Krishan Avtar Suri , Bishan Datt Gupta , Bupinder Singh Jaggi , Bal Krishan Kapahi , Naresh Kumar Satti , Musarat Amina , Bal Krishan Chandan , Neelam Sharma , Gurdarshan Singh
发明人： Ghulam Nabi Qazi , Om Parkash Suri , Kasturi Lal Bedi , Krishan Avtar Suri , Bishan Datt Gupta , Bupinder Singh Jaggi , Bal Krishan Kapahi , Naresh Kumar Satti , Musarat Amina , Bal Krishan Chandan , Neelam Sharma , Gurdarshan Singh
IPC分类号： A61K35/78 , A61K31/70 , A61K31/33 , A61K31/555 , A61K31/05
CPC分类号： A61K36/53 , Y10S514/893
摘要： A process of isolation of pure Acteoside of high hepatoprotection from plant Colerbrookea oppositifolia, said process comprising steps of drying aerial parts of the plant, grounding the dried parts into powder, percolating the powder with water or ethanol for 3-4 times to obtain an extract, filtering the extract for clearing of suspended particles to obtain supernatant, drying the supernatant at about 45 to 55° C. to obtain a residue, fractionating the residue with chloroform, ethyl acetate, and butanol successively, subjecting butanol fraction to adsorption chromatography of SiO2 after adding methanol to the fraction, charging the adsorbed fraction to glass column, eluting the column with solvents of increasing polarity of methanol:chloroform to obtain further fractions and repeating the process one more time, subjecting the fractions to column chromatography to obtain fractions, concentrating the fractions under reduced pressure to obtain acteoside as residue; and a method of effectively hepatoprotecting a subject using pure Acteoside from plant Colerbrookea oppositifolia, said method comprising steps of administering appropriate low-dose of the acteoside to the subject.
摘要翻译： 从植物Colerbrookea oppositifolia中分离出高保护酶的纯Acteoside的过程，所述方法包括干燥植物的地上部分，将干燥部分粉碎成粉末，用水或乙醇渗滤粉末3-4次以获得提取物 过滤提取物以清除悬浮颗粒以获得上清液，在约45至55℃下干燥上清液，得到残余物，依次用氯仿，乙酸乙酯和丁醇分馏残余物，将丁醇级分进行吸附层析 在将甲醇加入到级分中后，将吸附的级分装入玻璃柱，用极性升高的甲醇：氯仿溶剂洗脱柱，得到更多的级分并重复该过程一次， 进行柱色谱分离，得到级分，减压浓缩，得到作为残留物的acteoside; 该方法包括以下步骤：向受试者施用合适的低剂量的acteoside。
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公开(公告)号：US07119075B2
公开(公告)日：2006-10-10
申请号：US10404014
申请日：2003-03-31
申请人： Ghulam Nabi Qazi , Om Parkash Suri , Kasturi Lal Bedi , Inshad Ali Khan , Vijeshwar Verma , Rakesh Kamal Johri , Krishan Avtar Suri , Bishan Datt Gupta , Naresh Kumar Satti , Manoj Kumar Tikoo , Subhash Chander Sharma , Ashok Kumar Tikoo
发明人： Ghulam Nabi Qazi , Om Parkash Suri , Kasturi Lal Bedi , Inshad Ali Khan , Vijeshwar Verma , Rakesh Kamal Johri , Krishan Avtar Suri , Bishan Datt Gupta , Naresh Kumar Satti , Manoj Kumar Tikoo , Subhash Chander Sharma , Ashok Kumar Tikoo
IPC分类号： A61K31/70
CPC分类号： A61K45/06 , A61K31/00 , A61K31/4525 , A61K31/455 , A61K31/7048 , A61K2300/00
摘要： The present invention relates to the use of bioenhancers to decrease the resistance of microbial strains to anti-infective such an antibiotics and antifungals by potentiating the activities of anti-infective. This may be useful to reduce resistance in bacteria and yeast to aid in the treatment of certain infections and disease and to lower the concentration of antiinfectives necessary to inhibit the growth of microbial strains.
摘要翻译： 本发明涉及通过增强抗感染活性来降低微生物菌株对抗感染性抗生素和抗真菌剂的抗性的用途。 这可能有助于降低细菌和酵母中的抗性，以帮助治疗某些感染和疾病，并降低抑制微生物菌株生长所必需的抗感染药物的浓度。
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8.发明申请Bioavailability enhancing activity of carum carvi extracts and fractions thereof 审中-公开Carum carvi提取物及其馏分的生物利用度增加活性公开(公告)号：US20080292736A1
公开(公告)日：2008-11-27
申请号：US12011582
申请日：2008-01-28
申请人： Ghulam Nabi Qazi , Kasturi Lal Bedi , Rakesh Kamal Johri , Manoj Kumar Tikoo , Ashok Kumar Tikoo , Subhash Chandra Sharma , Tasaduaq Abdullah , Om Parkash Suri , Bishan Datt Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Ravi Kant Khajuria
发明人： Ghulam Nabi Qazi , Kasturi Lal Bedi , Rakesh Kamal Johri , Manoj Kumar Tikoo , Ashok Kumar Tikoo , Subhash Chandra Sharma , Tasaduaq Abdullah , Om Parkash Suri , Bishan Datt Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Ravi Kant Khajuria
IPC分类号： A61K36/23 , A61K36/9068
CPC分类号： A61K31/7048 , A61K31/496 , A61K31/497 , A61K36/23 , A61K36/67 , A61K36/9068 , A61K2300/00
摘要： The present invention relates to the use of extracts of Carum carvi as bioenhancers, either alone or in combination with piperine or Zingiber officinale extract to improve the bioavailability of a wide variety of drugs.
摘要翻译： 本发明涉及Carum carvi的提取物作为生物降解剂，单独使用或与胡椒碱或姜黄素提取物组合以提高各种药物的生物利用度。
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9.发明授权Bioavailability/bioefficacy enhancing activity of Cuminum cyminum and extracts and fractions thereof 有权孜然和提取物及其级分的生物利用度/生物功效增强活性公开(公告)号：US07514105B2
公开(公告)日：2009-04-07
申请号：US11360653
申请日：2006-02-23
申请人： Ghulam Nabi Qazi , Kasturi Lal Bedi , Rakesh Kamal Johri , Manoj Kumar Tikoo , Ashok Kumar Tikoo , Subhash Chander Sharma , Sheikh Tasaduq Abdullah , Om Parkash Suri , Bishan Datt Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Ravi Kant Khajuria , Surjit Singh , Anamika Khajuria , Bal Krishan Kapahi
发明人： Ghulam Nabi Qazi , Kasturi Lal Bedi , Rakesh Kamal Johri , Manoj Kumar Tikoo , Ashok Kumar Tikoo , Subhash Chander Sharma , Sheikh Tasaduq Abdullah , Om Parkash Suri , Bishan Datt Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Ravi Kant Khajuria , Surjit Singh , Anamika Khajuria , Bal Krishan Kapahi
IPC分类号： A61K36/00 , A61K36/752
CPC分类号： A61K45/06 , A23L33/105 , A23L33/15 , A23L33/16 , A23L33/175 , A61K31/43 , A61K31/4453 , A61K31/4709 , A61K31/496 , A61K31/545 , A61K31/704 , A61K31/7048 , A61K33/04 , A61K36/185 , A61K36/19 , A61K36/23 , A61K36/28 , A61K36/47 , A61K36/59 , A61K36/67 , A61K36/75 , A61K36/80 , A61K36/81 , A61K36/8965 , A61K2300/00
摘要： The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising: an effective amount of an extract and/or at least one bioactive fraction from Cuminum cyminum; one or more additive selected from drugs, nutrients, vitamins, nutraceuticals, herbal drugs/products, micro nutrients, antioxidants along with pharmaceuticaly acceptable additives/excipient, and optionally, an effective amount of piperine or extract/fraction of piper nigrum or piper longum; and a process for the preparation of such extracts and active fractions from plant Cuminum cyminum.
摘要翻译： 本发明涉及生物增强/生物利用度促进组合物，其包含：有效量的来自孜然的提取物和/或至少一种生物活性级分; 一种或多种选自药物，营养素，维生素，营养品，草药/产品，微量营养素，抗氧化剂以及药用可接受的添加剂/赋形剂的添加剂，以及任选的有效量的胡椒碱或胡椒或胡椒的提取物/级分; 以及从植物孜然中制备这些提取物和活性级分的方法。
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10.发明授权Bioavailability / bioefficacy enhancing activity of Cuminum cyminum and extracts and fractions thereof 有权孜然和提取物及其级分的生物利用度/生物功效增强活性公开(公告)号：US07070814B2
公开(公告)日：2006-07-04
申请号：US10386395
申请日：2003-03-11
申请人： Ghulam Nabi Qazi , Kasturi Lal Bedi , Rakesh Kamal Johri , Manoj Kumar Tikoo , Ashok Kumar Tikoo , Subhash Chander Sharma , Sheikh Tasaduq Absullah , Om Parkash Suri , Bishan Datt Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Ravi Kant Khajuria , Surjit Singh , Anamika Khajuria , Bal Krishan Kapahi
发明人： Ghulam Nabi Qazi , Kasturi Lal Bedi , Rakesh Kamal Johri , Manoj Kumar Tikoo , Ashok Kumar Tikoo , Subhash Chander Sharma , Sheikh Tasaduq Absullah , Om Parkash Suri , Bishan Datt Gupta , Krishan Avtar Suri , Naresh Kumar Satti , Ravi Kant Khajuria , Surjit Singh , Anamika Khajuria , Bal Krishan Kapahi
IPC分类号： A61K35/78
CPC分类号： A61K45/06 , A23L33/105 , A23L33/15 , A23L33/16 , A23L33/175 , A61K31/43 , A61K31/4453 , A61K31/4709 , A61K31/496 , A61K31/545 , A61K31/704 , A61K31/7048 , A61K33/04 , A61K36/185 , A61K36/19 , A61K36/23 , A61K36/28 , A61K36/47 , A61K36/59 , A61K36/67 , A61K36/75 , A61K36/80 , A61K36/81 , A61K36/8965 , A61K2300/00
摘要： The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising: an effective amount of an extract and/or at least one bioactive fraction from Cuminum cyminum; one or more additive selected from drugs, nutrients, vitamins, nutraceuticals, herbal drugs/products, micro nutrients, antioxidants along with pharmaceutically acceptable additives/excipient, and optionally, an effective amount of piperine or extract/fraction of piper nigrum or piper longum; and a process for the preparation of such extracts and active fractions from plant Cuminum cyminum.
摘要翻译： 本发明涉及生物增强/生物利用度促进组合物，其包含：有效量的来自孜然的提取物和/或至少一种生物活性级分; 一种或多种选自药物，营养素，维生素，营养品，草药/产品，微量营养素，抗氧化剂以及药学上可接受的添加剂/赋形剂的添加剂，以及任选的有效量的胡椒碱或胡椒或胡椒的提取物/级分; 以及从植物孜然中制备这些提取物和活性级分的方法。
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