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公开(公告)号：US06740336B2
公开(公告)日：2004-05-25
申请号：US10265024
申请日：2002-10-04
申请人： Vladimir S. Trubetskoy , Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , So Chun Wong , Jason Klein
发明人： Vladimir S. Trubetskoy , Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , So Chun Wong , Jason Klein
IPC分类号： A61K9127
CPC分类号： A61K48/0008
摘要： We describe a process for generating multilayer particles comprising condensing a polymer with an oppositely charged polymer to form a particle and sequentially adding oppositely charged polymers to the particle forming at least three layers of polymers. The process is used to form a composition for delivering a biologically active compound to a cell.
摘要翻译： 我们描述了一种产生多层颗粒的方法，包括将聚合物与带相反电荷的聚合物缩合形成颗粒，并依次向形成至少三层聚合物的颗粒中加入带相反电荷的聚合物。 该方法用于形成用于将生物活性化合物递送至细胞的组合物。
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公开(公告)号：US6126964A
公开(公告)日：2000-10-03
申请号：US778657
申请日：1997-01-03
申请人： Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , Vladimir S. Trubetskoy , Paul M. Slattum , Lisa J. Hanson
发明人： Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , Vladimir S. Trubetskoy , Paul M. Slattum , Lisa J. Hanson
CPC分类号： A61K47/48315 , A61K47/48192 , A61K47/48215 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/87
摘要： A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
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公开(公告)号：US06881576B2
公开(公告)日：2005-04-19
申请号：US10095752
申请日：2002-03-11
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/87
摘要： A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
摘要翻译： 为了将核酸递送至细胞，聚阴离子用于缩合的多核苷酸复合物。 络合物可以用适量的正电荷和/或负电荷形成，使得所得复合物可以递送到血管外空间并且可以进一步递送至细胞。
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4.发明授权公开(公告)号：US06706922B2
公开(公告)日：2004-03-16
申请号：US09993216
申请日：2001-11-16
申请人： Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , Vladimir S. Trubetskoy , Paul M. Slattum , Lisa J. Hanson
发明人： Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , Vladimir S. Trubetskoy , Paul M. Slattum , Lisa J. Hanson
IPC分类号： C07C21163
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041
摘要： A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
摘要翻译： 使用模板聚合在核酸存在下形成聚合物的方法。 此外，在异相体系中发生聚合的方法。 这些方法可用于递送核酸，用于冷凝核酸，用于形成核酸结合聚合物，用于形成含有核酸和聚合物的超分子复合物，并用于形成内聚电解质络合物。
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公开(公告)号：US06383811B2
公开(公告)日：2002-05-07
申请号：US09753990
申请日：2001-01-02
IPC分类号： A61K9127
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/87
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
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公开(公告)号：US07524680B2
公开(公告)日：2009-04-28
申请号：US10095681
申请日：2002-03-11
IPC分类号： C12N15/88
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/87
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
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公开(公告)号：US20080234222A1
公开(公告)日：2008-09-25
申请号：US12132030
申请日：2008-06-03
申请人： Jon A. Wolff , Vladimir S. Trubetskoy , Aaron G. Loomis , Paul M. Slattum , Sean D. Monahan , James E. Hagstrom , Vladimir G. Budker
发明人： Jon A. Wolff , Vladimir S. Trubetskoy , Aaron G. Loomis , Paul M. Slattum , Sean D. Monahan , James E. Hagstrom , Vladimir G. Budker
IPC分类号： A61K31/70
摘要： An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.
摘要翻译： 将离子聚合物用于“再充电”（具有不同电荷的另一层）缩合的多核苷酸复合物，用于向细胞递送核酸。 可以用合适量的正电荷或负电荷形成所得的再充电络合物，使得所得复合物具有所需的净电荷。
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8.发明授权公开(公告)号：US06960690B2
公开(公告)日：2005-11-01
申请号：US10005294
申请日：2001-12-05
申请人： Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , Vladimir S. Trubetskoy , Paul M. Slattum , Lisa J. Hanson
发明人： Jon A. Wolff , James E. Hagstrom , Vladimir G. Budker , Vladimir S. Trubetskoy , Paul M. Slattum , Lisa J. Hanson
IPC分类号： A61K47/48 , A61K48/00 , C12N15/87 , C07C211/63 , C07C69/52 , C07C233/00 , C12Q1/68
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041
摘要： A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
摘要翻译： 使用模板聚合在核酸存在下形成聚合物的方法。 此外，在异相体系中发生聚合的方法。 这些方法可用于递送核酸，用于冷凝核酸，用于形成核酸结合聚合物，用于形成含有核酸和聚合物的超分子复合物，并用于形成内聚电解质络合物。
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9.发明授权公开(公告)号：US06919091B2
公开(公告)日：2005-07-19
申请号：US10095680
申请日：2002-03-11
申请人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
发明人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/87
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
摘要翻译： 为了向细胞递送核酸，将聚二聚物用于缩合的多核苷酸复合物中。 络合物可以用适量的正电荷和/或负电荷形成，使得所得复合物可以递送到血管外空间并且可以进一步递送至细胞。
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公开(公告)号：US06794189B2
公开(公告)日：2004-09-21
申请号：US10095682
申请日：2002-05-10
IPC分类号： C12N1588
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/87
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
摘要翻译： 为了向细胞递送核酸，将聚二聚物用于缩合的多核苷酸复合物中。 络合物可以用适量的正电荷和/或负电荷形成，使得所得复合物可以递送到血管外空间并且可以进一步递送至细胞。
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