公开(公告)号：US08896239B2

公开(公告)日：2014-11-25

申请号：US12994106

申请日：2009-05-21

申请人： Vladimir Yegorovich Balakin

发明人： Vladimir Yegorovich Balakin

IPC分类号： H05H15/00 ,  A61N5/10 ,  H05H7/08 ,  H05H13/04

CPC分类号： A61N5/1042 ,  A61N5/1043 ,  A61N5/1064 ,  A61N5/1078 ,  A61N2005/1061 ,  A61N2005/1087 ,  H05H7/08 ,  H05H13/04 ,  H05H2007/082 ,  H05H2007/085 ,  H05H2007/087 ,  H05H2007/088 ,  H05H2277/11

摘要： The invention comprises a charged particle beam injection method and apparatus used in conjunction with multi-axis charged particle radiation therapy of cancerous tumors. The negative ion beam source includes a negative ion beam source, vacuum system, an ion beam focusing lens, and/or a tandem accelerator. The negative ion beam source uses electric field lines for focusing a negative ion beam. The negative ion source plasma chamber includes a magnetic material, which provides a magnetic field barrier between a high temperature plasma chamber and a low temperature plasma region. The injection system vacuum system and a synchrotron vacuum system are separated by a conversion foil, where negative ions are converted to positive ions. The foil is sealed to the edges of the vacuum tube providing for a higher partial pressure in the injection system vacuum chamber and a lower pressure in the synchrotron vacuum system.

摘要翻译： 本发明包括与癌肿瘤的多轴带电粒子放射治疗结合使用的带电粒子束注射方法和装置。 负离子束源包括负离子束源，真空系统，离子束聚焦透镜和/或串联加速器。 负离子束源使用电场线来聚焦负离子束。 负离子源等离子体室包括磁性材料，其在高温等离子体室和低温等离子体区域之间提供磁场屏障。 注射系统真空系统和同步加速器真空系统由转换箔分离，其中负离子转化为正离子。 箔片密封到真空管的边缘，在注射系统真空室中提供更高的分压，并且同步加速器真空系统中的压力较低。

公开(公告)号：US08901509B2

公开(公告)日：2014-12-02

申请号：US12994120

申请日：2009-05-21

申请人： Vladimir Yegorovich Balakin

发明人： Vladimir Yegorovich Balakin

IPC分类号： G21K1/08 ,  G21K1/087 ,  H05H7/10 ,  H05H7/04 ,  H05H13/04 ,  G21K1/14 ,  G21K1/093 ,  H05H7/08 ,  A61N5/10

CPC分类号： G21K1/087 ,  A61B6/4258 ,  A61N2005/1087 ,  G21K1/093 ,  G21K1/14 ,  H05H7/04 ,  H05H7/08 ,  H05H7/10 ,  H05H13/04

摘要： The invention comprises a multi-axis charged particle irradiation method and apparatus. The multi-axis controls includes separate or independent control of one or more of horizontal position, vertical position, energy control, and intensity control of the charged particle irradiation beam. Optionally, the charged particle beam is additionally controlled in terms of timing. Timing is coordinated with patient respiration and/or patient rotational positioning. Combined, the system allows multi-axis and multi-field charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful proximal distal energy about the tumor.

摘要翻译： 本发明包括多轴带电粒子照射方法和装置。 多轴控制包括对带电粒子照射束的水平位置，垂直位置，能量控制和强度控制中的一个或多个的单独或独立的控制。 可选地，带电粒子束根据定时被附加地控制。 时间与患者呼吸和/或患者旋转定位相协调。 综合起来，该系统允许肿瘤的多轴和多场带电粒子照射产生精确和准确的辐照剂量，使肿瘤附近存在有害的近端远端能量分布。

公开(公告)号：US08688197B2

公开(公告)日：2014-04-01

申请号：US12994125

申请日：2009-05-21

申请人： Vladimir Yegorovich Balakin

发明人： Vladimir Yegorovich Balakin

IPC分类号： A61B5/05

CPC分类号： A61N5/10 ,  A61N2005/1087 ,  G03B42/02 ,  G21K1/087 ,  G21K1/093 ,  G21K1/14 ,  H01J3/14 ,  H01J3/34 ,  H05H7/04 ,  H05H7/08 ,  H05H7/10 ,  H05H13/04

摘要： The invention comprises a patient positioning and/or repositioning system, such as a laying, semi-vertical, or seated patient positioning, alignment, and/or control method and apparatus used in conjunction with multi-axis charged particle radiation therapy. Patient positioning constraints optionally include one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are preferably movable and/or under computer control for rapid positioning, repositioning, and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the charged particle beam path to accurately and precisely target the tumor, and/or in system verification and validation.

摘要翻译： 本发明包括与多轴带电粒子放射治疗结合使用的患者定位和/或重新定位系统，例如铺设，半垂直或就座的患者定位，对准和/或控制方法和装置。 患者定位限制可选地包括以下中的一个或多个：座椅支撑件，后支撑件，头部支撑件，臂支撑件，膝盖支撑件和脚支撑件。 一个或多个定位限制优选地可移动和/或在计算机控制下进行，用于快速定位，重新定位和/或固定患者。 系统可选地使用位于与粒子束癌治疗系统的质子束路径基本相同的路径中的X射线束。 生成的图像可用于：相对于质子束路径精细调整身体对准，以控制带电粒子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。

公开(公告)号：US20110233423A1

公开(公告)日：2011-09-29

申请号：US12994130

申请日：2009-05-21

申请人： Vladimir Yegorovich Balakin

发明人： Vladimir Yegorovich Balakin

IPC分类号： A61N5/10

CPC分类号： G21K1/087 ,  A61N2005/1087 ,  G21K1/093 ,  G21K1/14 ,  H05H7/04 ,  H05H7/08 ,  H05H7/10 ,  H05H13/04

摘要： The invention comprises a multi-field charged particle irradiation method and apparatus. Radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Preferably, beam intensity is proportional to radiation dose delivery efficiency. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus. Optionally, multi-axis control of the charged particle beam is used simultaneously with the multi-field irradiation. Combined, the system allows multi-field and multi-axis charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful irradiation energy about the tumor.

摘要翻译： 本发明包括多场带电粒子照射方法和装置。 辐射通过入口点传递到肿瘤中，并且布拉格峰能量被靶向肿瘤的远端或远侧，从进入点。 从入口点向肿瘤的远端侧提供布拉格峰值能量从多个旋转方向重复。 优选地，束强度与辐射剂量递送效率成比例。 优选地，带电粒子治疗通过控制带电粒子束注射，加速，提取和/或靶向方法和装置来计时到患者呼吸。 可选地，带电粒子束的多轴控制与多场照射同时使用。 综合起来，该系统允许肿瘤的多场和多轴带电粒子照射产生精确和准确的照射剂量，对肿瘤分布有害的照射能量。

公开(公告)号：US20110182410A1

公开(公告)日：2011-07-28

申请号：US12994132

申请日：2009-05-21

申请人： Vladimir Yegorovich Balakin

发明人： Vladimir Yegorovich Balakin

IPC分类号： A61N5/10 ,  H01J1/50

CPC分类号： G21K1/087 ,  A61N2005/1087 ,  G21K1/093 ,  G21K1/14 ,  H05H7/04 ,  H05H7/08 ,  H05H7/10 ,  H05H13/04

摘要： The invention comprises a charged particle beam path coupling an injector, synchrotron accelerator, beam transport system, targeting system, and/or patient interface method and apparatus. Preferably, the injector comprises: a negative ion beam source, a two phase ion source vacuum system, an ion beam focusing lens, and/or a tandem accelerator. Preferably, the synchrotron comprises turning magnets, edge focusing magnets, magnetic field concentration magnets, winding and correction coils, flat magnetic field incident surfaces, and/or extraction elements. Preferably, the synchrotron, beam transport system, targeting system, and patient interface combine to allow multi-axis/multi-field irradiation, where multi-axis control comprises control of horizontal and vertical beam position, beam energy, and/or beam intensity and multi-field control comprises control of patient rotation and distribution of delivered energy in and about the tumor in a time controlled, targeted, accurate, precise, dosage controlled, and/or efficient manner.

摘要翻译： 本发明包括连接注射器，同步加速器，束输送系统，靶向系统和/或患者接口方法和装置的带电粒子束路径。 优选地，喷射器包括：负离子束源，两相离子源真空系统，离子束聚焦透镜和/或串联加速器。 优选地，同步加速器包括转动磁体，边缘聚焦磁体，磁场集中磁体，绕组和校正线圈，平坦磁场入射表面和/或提取元件。 优选地，同步加速器，光束传输系统，瞄准系统和患者接口组合以允许多轴/多场照射，其中多轴控制包括水平和垂直光束位置，光束能量和/或光束强度的控制，以及 多场控制包括以时间控制的，靶向的，准确的，精确的，剂量控制的和/或有效的方式来控制患者旋转和在肿瘤中和周围分布的能量。

公开(公告)号：US20110118530A1

公开(公告)日：2011-05-19

申请号：US12994106

申请日：2009-05-21

申请人： Vladimir Yegorovich Balakin

发明人： Vladimir Yegorovich Balakin

IPC分类号： A61N5/00

CPC分类号： A61N5/1042 ,  A61N5/1043 ,  A61N5/1064 ,  A61N5/1078 ,  A61N2005/1061 ,  A61N2005/1087 ,  H05H7/08 ,  H05H13/04 ,  H05H2007/082 ,  H05H2007/085 ,  H05H2007/087 ,  H05H2007/088 ,  H05H2277/11

摘要： The invention comprises a charged particle beam injection method and apparatus used in conjunction with multi-axis charged particle radiation therapy of cancerous tumors. The negative ion beam source includes a negative ion beam source, vacuum system, an ion beam focusing lens, and/or a tandem accelerator. The negative ion beam source uses electric field lines for focusing a negative ion beam. The negative ion source plasma chamber includes a magnetic material, which provides a magnetic field barrier between a high temperature plasma chamber and a low temperature plasma region. The injection system vacuum system and a synchrotron vacuum system are separated by a conversion foil, where negative ions are converted to positive ions. The foil is sealed to the edges of the vacuum tube providing for a higher partial pressure in the injection system vacuum chamber and a lower pressure in the synchrotron vacuum system.

摘要翻译： 本发明包括与癌肿瘤的多轴带电粒子放射治疗结合使用的带电粒子束注射方法和装置。 负离子束源包括负离子束源，真空系统，离子束聚焦透镜和/或串联加速器。 负离子束源使用电场线来聚焦负离子束。 负离子源等离子体室包括磁性材料，其在高温等离子体室和低温等离子体区域之间提供磁场屏障。 注射系统真空系统和同步加速器真空系统由转换箔分离，其中负离子转化为正离子。 箔片密封到真空管的边缘，在注射系统真空室中提供较高的分压，并且在同步加速器真空系统中具有较低的压力。

公开(公告)号：US09058910B2

公开(公告)日：2015-06-16

申请号：US12994117

申请日：2009-05-21

申请人： Vladimir Yegorovich Balakin

发明人： Vladimir Yegorovich Balakin

IPC分类号： H05H7/04 ,  G21K1/087 ,  G21K1/093 ,  G21K1/14 ,  H05H7/08 ,  H05H7/10 ,  H05H13/04 ,  A61N5/10

CPC分类号： G21K1/087 ,  A61N2005/1087 ,  G21K1/093 ,  G21K1/14 ,  H05H7/04 ,  H05H7/08 ,  H05H7/10 ,  H05H13/04

摘要： The invention comprises a charged particle beam acceleration method and apparatus used as part of multi-axis charged particle radiation therapy of cancerous tumors. The accelerator includes a synchrotron having advances in turning magnets, edge focusing magnets, magnetic field concentration magnets, and extraction and intensity control elements that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allows independent energy and intensity control of extracted charged particles from the synchrotron.

摘要翻译： 本发明包括一种带电粒子束加速方法和装置，用作癌肿瘤多轴带电粒子放射治疗的一部分。 加速器包括具有转向磁体，边缘聚焦磁体，磁场浓度磁体以及使同步加速器的总体尺寸最小化的提取和强度控制元件的同步加速器，提供严格控制的质子束，直接减小所需磁场的尺寸 ，直接降低了所需的工作功率，并允许从同步加速器中提取带电粒子的独立能量和强度控制。

公开(公告)号：US08957396B2

公开(公告)日：2015-02-17

申请号：US12994132

申请日：2009-05-21

申请人： Vladimir Yegorovich Balakin

发明人： Vladimir Yegorovich Balakin

IPC分类号： A61N5/00 ,  G21K1/087 ,  G21K1/093 ,  G21K1/14 ,  H05H7/04 ,  H05H7/08 ,  H05H7/10 ,  H05H13/04 ,  A61N5/10

CPC分类号： G21K1/087 ,  A61N2005/1087 ,  G21K1/093 ,  G21K1/14 ,  H05H7/04 ,  H05H7/08 ,  H05H7/10 ,  H05H13/04

摘要： The invention comprises a charged particle beam path coupling an injector, synchrotron accelerator, beam transport system, targeting system, and/or patient interface method and apparatus. Preferably, the injector comprises: a negative ion beam source, a two phase ion source vacuum system, an ion beam focusing lens, and/or a tandem accelerator. Preferably, the synchrotron comprises turning magnets, edge focusing magnets, magnetic field concentration magnets, winding and correction coils, flat magnetic field incident surfaces, and/or extraction elements. Preferably, the synchrotron, beam transport system, targeting system, and patient interface combine to allow multi-axis/multi-field irradiation, where multi-axis control comprises control of horizontal and vertical beam position, beam energy, and/or beam intensity and multi-field control comprises control of patient rotation and distribution of delivered energy in and about the tumor in a time controlled, targeted, accurate, precise, dosage controlled, and/or efficient manner.

摘要翻译： 本发明包括连接注射器，同步加速器，束输送系统，靶向系统和/或患者接口方法和装置的带电粒子束路径。 优选地，喷射器包括：负离子束源，两相离子源真空系统，离子束聚焦透镜和/或串联加速器。 优选地，同步加速器包括转动磁体，边缘聚焦磁体，磁场集中磁体，绕组和校正线圈，平坦磁场入射表面和/或提取元件。 优选地，同步加速器，光束传输系统，瞄准系统和患者接口组合以允许多轴/多场照射，其中多轴控制包括水平和垂直光束位置，光束能量和/或光束强度的控制，以及 多场控制包括以时间控制的，靶向的，准确的，精确的，剂量控制的和/或有效的方式来控制患者旋转和在肿瘤中和周围分布的能量。

公开(公告)号：US08766217B2

公开(公告)日：2014-07-01

申请号：US12994130

申请日：2009-05-21

申请人： Vladimir Yegorovich Balakin

发明人： Vladimir Yegorovich Balakin

IPC分类号： A61N5/10

CPC分类号： G21K1/087 ,  A61N2005/1087 ,  G21K1/093 ,  G21K1/14 ,  H05H7/04 ,  H05H7/08 ,  H05H7/10 ,  H05H13/04

摘要： The invention comprises a multi-field charged particle irradiation method and apparatus. Radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Preferably, beam intensity is proportional to radiation dose delivery efficiency. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus. Optionally, multi-axis control of the charged particle beam is used simultaneously with the multi-field irradiation. Combined, the system allows multi-field and multi-axis charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful irradiation energy about the tumor.

摘要翻译： 本发明包括多场带电粒子照射方法和装置。 辐射通过入口点传递到肿瘤中，并且布拉格峰能量被靶向肿瘤的远端或远侧，从进入点。 从入口点向肿瘤的远端侧提供布拉格峰值能量从多个旋转方向重复。 优选地，束强度与辐射剂量递送效率成比例。 优选地，带电粒子治疗通过控制带电粒子束注射，加速，提取和/或靶向方法和装置来计时到患者呼吸。 可选地，带电粒子束的多轴控制与多场照射同时使用。 综合起来，该系统允许肿瘤的多场和多轴带电粒子照射产生精确和准确的照射剂量，对肿瘤分布有害的照射能量。

公开(公告)号：US20110180720A1

公开(公告)日：2011-07-28

申请号：US12994117

申请日：2009-05-21

申请人： Vladimir Yegorovich Balakin

发明人： Vladimir Yegorovich Balakin

IPC分类号： H01J1/50

CPC分类号： G21K1/087 ,  A61N2005/1087 ,  G21K1/093 ,  G21K1/14 ,  H05H7/04 ,  H05H7/08 ,  H05H7/10 ,  H05H13/04

摘要： The invention comprises a charged particle beam acceleration method and apparatus used as part of multi-axis charged particle radiation therapy of cancerous tumors. The accelerator includes a synchrotron having advances in turning magnets, edge focusing magnets, magnetic field concentration magnets, and extraction and intensity control elements that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allows independent energy and intensity control of extracted charged particles from the synchrotron.

摘要翻译： 本发明包括一种带电粒子束加速方法和装置，用作癌肿瘤多轴带电粒子放射治疗的一部分。 加速器包括具有转向磁体，边缘聚焦磁体，磁场浓度磁体以及使同步加速器的总体尺寸最小化的提取和强度控制元件的同步加速器，提供严格控制的质子束，直接减小所需磁场的尺寸 ，直接降低了所需的工作功率，并允许从同步加速器中提取带电粒子的独立能量和强度控制。