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1.发明授权Asymmetric hydrogenation of aromatic-substituted olefins using organoruthenium catalyst 失效使用有机钌催化剂对芳族取代烯烃进行不对称氢化
公开(公告)号：US5304524A
公开(公告)日：1994-04-19
申请号：US958525
申请日：1992-10-08
CPC分类号： B01J31/2295 , B01J31/2234 , B01J31/24 , B01J31/2452 , B01J2231/645 , B01J2531/0266 , B01J2531/821 , B01J31/0235 , B01J31/30
摘要： A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R.sub.1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or substituted aryl is disclosed.
摘要翻译： 公开了用于不对称还原式IMA的羧酸或其胺盐的方法，其中R和R 1相同或不同，并且是氢，烷基，环烷基或卤代烷基，Ar是芳基或取代的芳基。
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2.发明授权Asymmetric hydrogenation of aromatic-substituted olefins using metal or metal alloy catalysts 失效使用金属或金属合金催化剂对芳族取代烯烃进行不对称加氢
公开(公告)号：US5190905A
公开(公告)日：1993-03-02
申请号：US716014
申请日：1991-06-17
CPC分类号： B01J31/2452 , B01J31/24 , B01J31/28 , C07C51/36 , C07F15/0053 , C07F15/025 , C07F15/045 , B01J2231/645 , B01J2531/0266 , B01J2531/62 , B01J2531/821 , B01J2531/842 , B01J2531/847
摘要： A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R.sub.1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or substituted aryl is disclosed.
摘要翻译： 公开了用于不对称还原式IMA的羧酸或其胺盐的方法，其中R和R 1相同或不同，并且是氢，烷基，环烷基或卤代烷基，Ar是芳基或取代的芳基。
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3.发明授权Asymmetric hydrogenation of aromatic-substituted olefins using organoiridium catalyst 失效使用有机铱催化剂对芳族取代烯烃进行不对称加氢
公开(公告)号：US5187281A
公开(公告)日：1993-02-16
申请号：US716016
申请日：1991-06-17
CPC分类号： C07F15/004 , B01J31/2234 , B01J31/2452 , C07C51/36 , B01J2231/645 , B01J2531/0266 , B01J2531/827
摘要： A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R.sub.1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or substituted aryl is disclosed.
摘要翻译： 公开了用于不对称还原式IMA的羧酸或其胺盐的方法，其中R和R 1相同或不同，并且是氢，烷基，环烷基或卤代烷基，Ar是芳基或取代的芳基。
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4.发明授权
公开(公告)号：US5191095A
公开(公告)日：1993-03-02
申请号：US716015
申请日：1991-06-17
IPC分类号： B01J31/22 , B01J31/24 , C07C51/36 , C07C231/18
CPC分类号： B01J31/2452 , B01J31/2234 , C07C231/18 , C07C51/36 , B01J2231/645 , B01J2531/0266 , B01J2531/821
摘要： A process for the asymmetric reduction of olefinic amides of the formula ##STR1## where R and R.sub.1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or substituted aryl is disclosed.
摘要翻译： 公开了一种式（Ia）的烯属酰胺的不对称还原方法，其中R和R 1相同或不同，并且是氢，烷基，环烷基或卤代烷基，Ar是芳基或取代的芳基。
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5.发明授权Asymmetric hydrogenation of aromatic-substituted olefins using organorhenium catalyst 失效使用有机铼催化剂对芳族取代烯烃进行不对称加氢
公开(公告)号：US5187136A
公开(公告)日：1993-02-16
申请号：US716013
申请日：1991-06-17
CPC分类号： B01J31/2452 , B01J31/0237 , B01J31/24 , B01J31/28 , C07C51/36 , C07F13/005 , B01J2231/645 , B01J2531/0266 , B01J2531/74
摘要： A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R.sub.1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or substituted aryl is disclosed.
摘要翻译： 公开了用于不对称还原式IMA的羧酸或其胺盐的方法，其中R和R 1相同或不同，并且是氢，烷基，环烷基或卤代烷基，Ar是芳基或取代的芳基。
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6.发明授权Asymmetric hydrogenation of aromatic-substituted olefins using cationic ruthenium(III) complexes 失效使用阳离子钌（III）络合物对芳族取代的烯烃进行不对称氢化
公开(公告)号：US5177231A
公开(公告)日：1993-01-05
申请号：US716005
申请日：1991-06-17
IPC分类号： C07C51/36 , C07C51/487 , C07F15/00
CPC分类号： C07C51/487 , C07C51/36 , C07F15/0053
摘要： A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R.sub.1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or substituted aryl is disclosed.
摘要翻译： 公开了用于不对称还原式IMA的羧酸或其胺盐的方法，其中R和R 1相同或不同，并且是氢，烷基，环烷基或卤代烷基，Ar是芳基或取代的芳基。
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7.发明授权Asymmetric hydrogenation of aromatic-substituted olefins using organonickel catalyst 失效使用有机镍催化剂对芳族取代烯烃进行不对称加氢
公开(公告)号：US5202472A
公开(公告)日：1993-04-13
申请号：US716012
申请日：1991-06-17
IPC分类号： C07C51/36 , C07C211/27
CPC分类号： C07C51/36 , C07C211/27
摘要： A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R.sub.1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or substituted aryl is disclosed.
摘要翻译： 公开了用于不对称还原式IMA的羧酸或其胺盐的方法，其中R和R 1相同或不同，并且是氢，烷基，环烷基或卤代烷基，Ar是芳基或取代的芳基。
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8.发明授权Asymmetric hydrogenation of aromatic-substituted olefins using organo-cobalt catalyst 失效使用有机钴催化剂对芳族取代烯烃进行不对称加氢
公开(公告)号：US5187135A
公开(公告)日：1993-02-16
申请号：US716017
申请日：1991-06-17
CPC分类号： B01J31/2452 , B01J31/2234 , B01J31/24 , C07C51/36 , C07F15/065 , B01J2231/645 , B01J2531/0266 , B01J2531/845
摘要： A process for the asymmetric reduction of carboxylic acids of the formula ##STR1## or the amine salts thereof, where R and R.sub.1 are the same or different and are hydrogen, alkyl, cycloalkyl or haloalkyl and Ar is aryl or substituted aryl is disclosed.
摘要翻译： 公开了用于不对称还原式IMA的羧酸或其胺盐的方法，其中R和R 1相同或不同，并且是氢，烷基，环烷基或卤代烷基，Ar是芳基或取代的芳基。
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公开(公告)号：US5315027A
公开(公告)日：1994-05-24
申请号：US62906
申请日：1993-05-11
CPC分类号： C07C67/36
摘要： A process for preparing alkyl esters of ibuprofen is provided. A 1-halo-1-(4-isobutylphenyl)ethane is reacted in an anhydrous medium with carbon monoxide in the presence of an alkoxide source at a temperature between about 10.degree. C. and about 200.degree. C. An excess of several moles of alcohol is preferred. An acid such as hydrogen chloride may also be added. As catalyst, a palladium compound having at least one acid-stable ligand is present; however, an excess of ligand over palladium is advantageous.
摘要翻译： 提供了制备布洛芬烷基酯的方法。 1-卤代-1-（4-异丁基苯基）乙烷在无水介质中与一氧化碳在醇盐源的存在下在约10℃至约200℃的温度下反应。过量数摩尔 优选酒精。 还可以加入酸如氯化氢。 作为催化剂，存在具有至少一个酸稳定配体的钯化合物; 然而，过量的配体在钯上是有利的。
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公开(公告)号：US5248813A
公开(公告)日：1993-09-28
申请号：US960660
申请日：1992-10-14
IPC分类号： C07B57/00 , C07C51/487
CPC分类号： C07C51/487 , C07B57/00
摘要： A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is reacted with a base producing a salt that has the following properties:(1) has at least one eutectic point;(2) a composition that is not at the eutectic point; and(3) a eutectic composition that is closer to the racemic composition than is the eutectic composition of said aryl-substituted carboxylic acid.Substantially pure, enantiomeric salt is separated, leaving a mother liquor comprising the solvent and aryl-substituted aliphatic carboxylic acid enriched in the other enantiomer.
摘要翻译： 描述了获得芳基取代的脂肪族羧酸的基本上纯的对映异构体的方法。 该方法首先利用从动力学拆分，非对映体结晶或不对称合成方法获得的芳基取代的脂族羧酸的对映体富集混合物。 该富集的混合物与产生具有以下性质的盐的碱反应：（1）具有至少一个共晶点; （2）不在共晶点的组成; 和（3）比所述芳基取代的羧酸的共晶组成更接近外消旋组合物的共晶组合物。 分离基本上纯的对映异构体盐，留下含有溶剂的母液和富集在另一对映异构体中的芳基取代的脂族羧酸。
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