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    Analyte sensing and response system
    1.
    发明申请
    Analyte sensing and response system 有权
    分析物检测和响应系统

    公开(公告)号：US20080027301A1

    公开(公告)日：2008-01-31

    申请号：US11592034

    申请日：2006-11-01

    申请人： W. Kenneth Ward ,  Michael D. Wood ,  Heather M. Duman ,  Bala Nair

    发明人： W. Kenneth Ward ,  Michael D. Wood ,  Heather M. Duman ,  Bala Nair

    IPC分类号： A61K9/22 ,  A61B5/00

    CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/7239

    摘要： Electrochemical systems for measuring an analyte concentration, and correcting any surplus or deficiency in the measured concentration. More specifically, systems for measuring an analyte level in a fluid with an implantable sensor, processing the measurements with an algorithm, and determining an appropriate fluid infusion rate in response to the measurements.

    摘要翻译： 用于测量分析物浓度的电化学系统，以及校正测量浓度中的任何剩余或不足。 更具体地，用于利用可植入传感器测量流体中的分析物水平的系统，用算法处理测量值，以及响应于测量确定合适的流体输注速率。

    Analyte sensing and response system
    2.
    发明授权
    Analyte sensing and response system 有权
    分析物检测和响应系统

    公开(公告)号：US08114023B2

    公开(公告)日：2012-02-14

    申请号：US11592034

    申请日：2006-11-01

    申请人： W. Kenneth Ward ,  Michael D. Wood ,  Heather M. Duman ,  Bala Nair

    发明人： W. Kenneth Ward ,  Michael D. Wood ,  Heather M. Duman ,  Bala Nair

    IPC分类号： A61B5/00 ,  A61B5/05

    CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/7239

    摘要： Electrochemical systems for measuring an analyte concentration, and correcting any surplus or deficiency in the measured concentration. More specifically, systems for measuring an analyte level in a fluid with an implantable sensor, processing the measurements with an algorithm, and determining an appropriate fluid infusion rate in response to the measurements.

    摘要翻译： 用于测量分析物浓度的电化学系统，以及校正测量浓度中的任何剩余或不足。 更具体地，用于利用可植入传感器测量流体中的分析物水平的系统，用算法处理测量值，以及响应于测量确定合适的流体输注速率。

    Implantable biosensor
    3.
    发明授权
    Implantable biosensor 有权
    植入式生物传感器

    公开(公告)号：US07433727B2

    公开(公告)日：2008-10-07

    申请号：US10948954

    申请日：2004-09-24

    申请人： W. Kenneth Ward ,  Michael D. Wood

    发明人： W. Kenneth Ward ,  Michael D. Wood

    IPC分类号： A61B5/05 ,  A61B5/00

    CPC分类号： A61B5/14865 ,  A61B5/14532 ,  C12Q1/005

    摘要： The invention consists of a sensor with multiple indicating (sensing) electrodes covered with a selectively permeable membrane for monitoring fluid concentrations in a biological environment. The indicating electrodes respond to changes in certain analytes, such as glucose, through an enzyme-mediated reaction. The currents generated from the enzyme-mediated reactions are transmitted through radio signals to an external receiver where the information is processed and recorded. Through the use of various biomaterials and biochemicals associated with the sensor, the monitoring accuracy is improved and the overall viability is prolonged. The process of foreign body fibrosis (formation of a scar capsule around the implanted sensor) eventually limits the functional life of the device. We teach methods of delivery of certain biochemicals that can increase the functional life of the sensor by inhibiting the formation of the foreign body capsule or by stimulating the growth of capillaries into the capsule.

    摘要翻译： 本发明包括具有多个指示（感测）电极的传感器，该电极覆盖有用于监测生物环境中的流体浓度的选择性渗透膜。 指示电极通过酶介导的反应响应某些分析物（例如葡萄糖）的变化。 从酶介导的反应产生的电流通过无线电信号传输到信息被处理和记录的外部接收器。 通过使用与传感器相关的各种生物材料和生物化学品，提高了监测精度，延长了整体的生存能力。 异物纤维化（植入传感器周围形成疤痕胶囊）的过程最终限制了器械的功能寿命。 我们教导了递送某些生物化学物质的方法，这些生物化学物质可以通过抑制异物胶囊的形成或通过刺激毛细血管进入胶囊来增加传感器的功能寿命。

    METHOD AND APPARATUS FOR BACKGROUND CURRENT ARRANGEMENTS FOR A BIOSENSOR
    5.
    发明申请
    METHOD AND APPARATUS FOR BACKGROUND CURRENT ARRANGEMENTS FOR A BIOSENSOR 失效
    用于生物传感器的背景安排的方法和装置

    公开(公告)号：US20100198031A1

    公开(公告)日：2010-08-05

    申请号：US12758638

    申请日：2010-04-12

    申请人： W. Kenneth Ward

    发明人： W. Kenneth Ward

    IPC分类号： A61B5/1468

    CPC分类号： A61B5/14532 ,  A61B5/1486

    摘要： Embodiments of the present invention provide for raising a background current setting for a biosensor above the actual (measured) background current present (i.e., overestimating the background current), particularly in the hypoglycemic range, to improve sensor accuracy and decrease the chance of glucose value overestimation by the sensor.

    摘要翻译： 本发明的实施例提供了将生物传感器的背景电流设置提高到存在的实际（测量的）背景电流之上（即，高估了背景电流），特别是在低血糖范围内，以提高传感器精度并降低葡萄糖值的机会 传感器过高估计

    METHOD AND APPARATUS FOR INSERTION OF A SENSOR USING AN INTRODUCER
    6.
    发明申请
    METHOD AND APPARATUS FOR INSERTION OF A SENSOR USING AN INTRODUCER 审中-公开
    使用导引器插入传感器的方法和装置

    公开(公告)号：US20080139903A1

    公开(公告)日：2008-06-12

    申请号：US11952033

    申请日：2007-12-06

    申请人： Robert Bruce ,  W. Kenneth Ward ,  Richard G. Sass ,  Jon Fortuna ,  Mark Neinast

    发明人： Robert Bruce ,  W. Kenneth Ward ,  Richard G. Sass ,  Jon Fortuna ,  Mark Neinast

    IPC分类号： A61B17/34

    CPC分类号： A61B17/3468 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/6882 ,  A61B17/3415 ,  A61B17/3476 ,  A61B2017/00544 ,  A61B2017/00548 ,  A61B2017/3407

    摘要： A device and method for delivering a device such as a sensor or fluid transport structure or a fluid transport structure sensor combination into, for example, animal skin. Such a device utilizes an introducer device such as a needle or trocar to puncture skin and allow a sensor to enter through the resultant skin puncture. A device in accordance with embodiments of the present invention includes a housing for mounting to animal skin including an opening for receiving both the distal end of an analyte sensor and the end of an introducer, an actuator device for forcing the introducer from a first position within the housing, through the exit port to a second position, with sufficient force to puncture skin.

    摘要翻译： 用于将例如传感器或流体输送结构或流体输送结构传感器组合的装置输送到例如动物皮肤的装置和方法。 这种装置利用诸如针或套针针的导引装置刺穿皮肤，并允许传感器通过所产生的皮肤穿刺进入。 根据本发明的实施例的装置包括用于安装到动物皮肤的壳体，包括用于接收分析物传感器的远端和导引器的端部的开口，用于将导引器从第一位置强迫的致动器装置 通过出口到第二位置，壳体具有足够的力刺穿皮肤。

    METHOD AND APPARATUS FOR INSERTION OF A SENSOR
    8.
    发明申请
    METHOD AND APPARATUS FOR INSERTION OF A SENSOR 有权
    传感器插入方法和装置

    公开(公告)号：US20120265042A1

    公开(公告)日：2012-10-18

    申请号：US13415828

    申请日：2012-03-08

    申请人： Mark Neinast ,  Robert Bruce ,  W. Kenneth Ward ,  Richard G. Sass ,  Jon Fortuna

    发明人： Mark Neinast ,  Robert Bruce ,  W. Kenneth Ward ,  Richard G. Sass ,  Jon Fortuna

    IPC分类号： A61B5/1473

    CPC分类号： A61B5/6849 ,  A61B5/14532 ,  A61B5/1473 ,  A61B17/3403 ,  A61B17/3468

    摘要： A device and method for delivering a device such as a sensor or fluid transport structure or a fluid transport structure sensor combination into, for example, mammalian skin. Such a device allows a sensor to penetrate mammalian skin without the use of an introducer device such as a needle. A device in accordance with embodiments of the present disclosure includes a housing for attachment to mammalian skin including an exit port for receiving the distal end of a biosensor and an injection activation device including a mechanism for forcing the sensing device from a first position within the housing, through the exit port to a second position, with sufficiently high velocity to partially penetrate the mammalian skin.

    摘要翻译： 一种用于将例如传感器或流体输送结构或流体输送结构传感器组合的装置输送到例如哺乳动物皮肤的装置和方法。 这种装置允许传感器穿透哺乳动物皮肤而不使用诸如针的引入装置。 根据本公开的实施例的装置包括用于附接到哺乳动物皮肤的壳体，包括用于接收生物传感器的远端的出口端口和包括用于将感测装置从壳体内的第一位置强制的机构的注射激活装置 通过出口到第二位置，具有足够高的速度以部分地穿透哺乳动物皮肤。

    Easy-to-use multi-use body fluid specimen collection and analyte sensing assembly
    10.
    发明授权
    Easy-to-use multi-use body fluid specimen collection and analyte sensing assembly 失效
    易于使用的多用途体液标本收集和分析物检测组件

    公开(公告)号：US07862519B1

    公开(公告)日：2011-01-04

    申请号：US10463848

    申请日：2003-06-16

    申请人： W. Kenneth Ward ,  Richard G. Sass

    发明人： W. Kenneth Ward ,  Richard G. Sass

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14532 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/15105 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/157

    摘要： A multiple use analyte sensing assembly that includes a long, thin conductor. A plurality of sensing sites are spaced along the conductor and each sensing site includes a membrane system adapted to create a current when placed into contact with body fluid containing the analyte. The assembly also includes a housing, having an aperture, an uptake spool and a payout spool, the conductor being wrapped about the payout spool before the sensing assembly is used. A sensor positioning actuator turns the uptake spool to move each sensing site, in sequence, to the housing aperture and then to the uptake spool. The assembly also includes a skin broaching assembly, having a multiplicity of lancets and a lancet positioning actuator adapted to move each lancet to the aperture. In addition, a lancet use actuator is adapted to move each lancet at least partially through the aperture and then back again.

    摘要翻译： 多用途分析物感测组件，其包括长而薄的导体。 多个感测位置沿着导体间隔开，并且每个感测位置包括适于当与包含分析物的体液接触时产生电流的膜系统。 组件还包括具有孔的外壳，吸收卷轴和支承卷轴，在使用感测组件之前，导体围绕放电卷轴缠绕。 传感器定位致动器转动摄影卷轴，以将每个感测位置依次移动到壳体孔口，然后到摄影卷轴。 组件还包括皮肤拉削组件，其具有多个刺血针和适于将每个刺血针移动到孔的刺血针定位致动器。 此外，柳叶刀使用致动器适于至少部分地移动每个刺血针穿过孔，然后再次返回。