公开(公告)号：US08845530B2

公开(公告)日：2014-09-30

申请号：US11966685

申请日：2007-12-28

申请人： Robert Bruce ,  Richard G. Sass ,  W. Kenneth Ward

发明人： Robert Bruce ,  Richard G. Sass ,  W. Kenneth Ward

IPC分类号： A61B5/00 ,  A61B5/1486 ,  A61B5/145

CPC分类号： A61B5/14532 ,  A61B5/0031 ,  A61B5/14865 ,  A61B5/6849 ,  A61B2560/0285 ,  A61B2560/045

摘要： A device, system, and method for delivering a device such as a sensor or fluid transport structure or a fluid transport structure sensor combination into, for example, mammalian skin and receiving, analyzing, and displaying signals from the device such as a sensor are disclosed. A system in accordance with embodiments of the present invention includes a reusable sensor assembly including a transmitter, microcontroller, and housing plus a disposable sensor assembly including a housing having an opening for receiving both the distal end of a biosensor, a sensor insertion guidance structure, and a transmission apparatus for transmitting signals received from the sensor to a reusable sensor assembly for transmission to an external electronic monitoring unit.

摘要翻译： 公开了一种用于将诸如传感器或流体输送结构或流体输送结构传感器组合的装置传送到例如哺乳动物皮肤并且从诸如传感器的装置接收，分析和显示信号的装置，系统和方法 。 根据本发明的实施例的系统包括可重复使用的传感器组件，其包括发射器，微控制器和壳体以及一次性传感器组件，其包括具有用于接收生物传感器的远端的开口的壳体，传感器插入引导结构， 以及发送装置，用于将从所述传感器接收到的信号发送到可重复使用的传感器组件，以传输到外部电子监视单元。

公开(公告)号：US20080269657A1

公开(公告)日：2008-10-30

申请号：US12108874

申请日：2008-04-24

申请人： Allen Brenneman ,  Richard G. Sass ,  W. Kenneth Ward ,  Jennifer Matson ,  Dennis Slomski ,  Robert Bruce ,  Leslie Wood ,  Isaac Federiuk

发明人： Allen Brenneman ,  Richard G. Sass ,  W. Kenneth Ward ,  Jennifer Matson ,  Dennis Slomski ,  Robert Bruce ,  Leslie Wood ,  Isaac Federiuk

IPC分类号： A61B19/02 ,  A61F13/02

CPC分类号： A61F15/004 ,  A61B46/10 ,  A61B2046/205 ,  A61F2013/00153 ,  A61F2013/00544 ,  A61F2013/0094

摘要： Embodiments of the present invention provide an adhesive overbandage. In an embodiment, there is provided an adhesive overbandage for use with a biosensor. An exemplary overbandage comprises a frame having an upper surface, a lower surface, an outer boundary and an inner boundary, wherein the inner boundary defines an interior opening configured to receive a monitoring device, adhesive disposed on the lower surface of the frame, and a release liner removably coupled to the adhesive.

摘要翻译： 本发明的实施例提供了粘合剂过度粘合。 在一个实施例中，提供了与生物传感器一起使用的粘合剂过度捆绑。 示例性的超宽带包括具有上表面，下表面，外边界和内边界的框架，其中内边界限定被配置为接收监视设备的内部开口，设置在框架的下表面上的粘合剂，以及 可拆卸地联接到粘合剂上的释放衬垫。

公开(公告)号：US06792316B2

公开(公告)日：2004-09-14

申请号：US10038560

申请日：2002-01-03

申请人： Richard G. Sass

发明人： Richard G. Sass

IPC分类号： A61M105

CPC分类号： A61N1/05

摘要： A cardiac implant electric cable, comprising a conductive lead adapted to supply power to a cardiac implant and a coaxial lead adapted to provide an expanded information conduit to and from said cardiac implant. Also, a bioelectrical stimulus implant cable may comprise a set of fibrils, each of which has a diameter of less than 30 &mgr;m and which are configured together longitudinally. The set of fibrils is electrically isolated by insulative material.

摘要翻译： 一种心脏植入电缆，包括适于向心脏植入物供电的导电引线和适于向所述心脏植入物提供扩展信息导管的同轴引线。 此外，生物电刺激植入电缆可以包括一组原纤维，每组原纤维具有小于30μm的直径并且纵向配置在一起。 该原纤维组由绝缘材料电隔离。

公开(公告)号：US20080139903A1

公开(公告)日：2008-06-12

申请号：US11952033

申请日：2007-12-06

申请人： Robert Bruce ,  W. Kenneth Ward ,  Richard G. Sass ,  Jon Fortuna ,  Mark Neinast

发明人： Robert Bruce ,  W. Kenneth Ward ,  Richard G. Sass ,  Jon Fortuna ,  Mark Neinast

IPC分类号： A61B17/34

CPC分类号： A61B17/3468 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/6882 ,  A61B17/3415 ,  A61B17/3476 ,  A61B2017/00544 ,  A61B2017/00548 ,  A61B2017/3407

摘要： A device and method for delivering a device such as a sensor or fluid transport structure or a fluid transport structure sensor combination into, for example, animal skin. Such a device utilizes an introducer device such as a needle or trocar to puncture skin and allow a sensor to enter through the resultant skin puncture. A device in accordance with embodiments of the present invention includes a housing for mounting to animal skin including an opening for receiving both the distal end of an analyte sensor and the end of an introducer, an actuator device for forcing the introducer from a first position within the housing, through the exit port to a second position, with sufficient force to puncture skin.

摘要翻译： 用于将例如传感器或流体输送结构或流体输送结构传感器组合的装置输送到例如动物皮肤的装置和方法。 这种装置利用诸如针或套针针的导引装置刺穿皮肤，并允许传感器通过所产生的皮肤穿刺进入。 根据本发明的实施例的装置包括用于安装到动物皮肤的壳体，包括用于接收分析物传感器的远端和导引器的端部的开口，用于将导引器从第一位置强迫的致动器装置 通过出口到第二位置，壳体具有足够的力刺穿皮肤。

公开(公告)号：US4552989A

公开(公告)日：1985-11-12

申请号：US634316

申请日：1984-07-24

申请人： Richard G. Sass

发明人： Richard G. Sass

IPC分类号： H01B11/18 ,  H01B11/20 ,  H01B11/00

CPC分类号： H01B11/1834 ,  H01B11/20

摘要： A multi-conductor cable including a plurality of miniature coaxial conductor pairs, each including an inner conductor supported by a very thin tubular layer of solid, relatively stiff dielectic material, surrounded by a much thicker wrapping of dielectric tape having a lower dielectric constant than that of the tubular layer. An outer conductor of multiple strands of wire is helically laid about the dielectric tape wrapping. The tubular layer provides mechanical support for each inner conductor, protecting against breakage due to bending of the individual conductor strands, without significantly increasing either the capacitance or diameter of the coaxial conductor pairs.

摘要翻译： 一种包括多个微型同轴导体对的多导体电缆，每个包含一个内部导体，该内部导体由固体，相对刚硬的介电常数材料的非常薄的管状层支撑，该导电体被较厚介电常数的绝缘胶带缠绕在一起。 的管状层。 多根绞线的外导体螺旋地放置在介质带包裹上。 管状层为每个内部导体提供机械支撑，防止由于各个导体股线的弯曲而导致的破坏，而不会显着增加同轴导体对的电容或直径。

公开(公告)号：US20130217983A1

公开(公告)日：2013-08-22

申请号：US13731000

申请日：2012-12-29

申请人： Mihailo V. Rebec ,  Slavko N. Rebec ,  Richard G. Sass

发明人： Mihailo V. Rebec ,  Slavko N. Rebec ,  Richard G. Sass

IPC分类号： A61B5/1459 ,  A61B5/145

CPC分类号： A61B5/1459 ,  A61B5/14532 ,  Y10T29/49826

摘要： Embodiments provide analyte sensors, such as implantable analyte sensors, and methods of producing the same. An implantable sensor may include a base with a plurality of chambers. One or more sensor reagents may be retained within the chambers to form analysis regions. A membrane may be coupled to the chambers over the sensor reagents. The implantable sensor may be implanted into the dermis of a subject. One or more of the sensor reagents may exhibit a color change in response to the presence of a target analyte or reaction product thereof. The wavelengths of light reflected from the analysis regions may be detected and analyzed to determine a target analyte concentration. One or more portions of the sensor or components thereof may be configured to facilitate calibration of the sensor, correction of an optical signal obtained from the sensor by a reader device to accommodate variations in the surrounding tissues, and/or calculation of a representative value by a reader device.

摘要翻译： 实施例提供分析物传感器，例如可植入分析物传感器及其生产方法。 可植入传感器可以包括具有多个室的底座。 一个或多个传感器试剂可以保留在室内以形成分析区域。 膜可以通过传感器试剂连接到腔室。 植入式传感器可以植入受试者的真皮中。 一种或多种传感器试剂可以响应于目标分析物或其反应产物的存在而显示出颜色变化。 可以检测和分析从分析区域反射的光的波长以确定目标分析物浓度。 传感器或其组件的一个或多个部分可以被配置为便于传感器的校准，由读取器装置校正由传感器获得的光学信号，以适应周围组织的变化，和/或代表值的计算由 阅读器设备

公开(公告)号：US08187433B2

公开(公告)日：2012-05-29

申请号：US11538340

申请日：2006-10-03

申请人： W. Kenneth Ward ,  Richard G. Sass

发明人： W. Kenneth Ward ,  Richard G. Sass

IPC分类号： C25B11/02 ,  C25B11/08 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/6848 ,  Y10T29/49

摘要： A sensing element adapted to, at least in part, be inserted into a mammalian body. The sensing element is made up of a core of a structurally robust metal and a plated portion made of an electrochemically active metal conjoined to at least a portion of the core. This sensing element may be used as part of a method for the continuous or intermittent monitoring of an analyte within a mammalian body. The method includes inserting at least a portion of the sensing element into the mammalian body and measuring any electric current produced by at least of portion of the sensor.

摘要翻译： 适于至少部分地插入哺乳动物体内的传感元件。 感测元件由结构坚固的金属的芯和由结合至芯的至少一部分的电化学活性金属制成的电镀部分构成。 该感测元件可以用作用于连续或间歇地监测哺乳动物体内的分析物的方法的一部分。 该方法包括将感测元件的至少一部分插入哺乳动物体内并测量由传感器的至少部分产生的任何电流。

公开(公告)号：US07228162B2

公开(公告)日：2007-06-05

申请号：US10342144

申请日：2003-01-13

申请人： W. Kenneth Ward ,  Richard G. Sass ,  Mark Nynest ,  Ellen Anderson ,  Lawrence B. Jansen

发明人： W. Kenneth Ward ,  Richard G. Sass ,  Mark Nynest ,  Ellen Anderson ,  Lawrence B. Jansen

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： A61B5/14865 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/15113 ,  A61B5/15151 ,  A61B5/15163 ,  A61B5/157 ,  A61B5/6848

摘要： A method of measuring an analyte concentration in body fluid in an animal body having skin and subcutaneous soft tissue that includes body fluid. The method comprises, introducing a portion of an analyte-measuring device into the subcutaneous soft tissue. The analyte-measuring device includes an analyte sensing element, having a sharpened distal end to facilitate introduction into the animal body. Additionally the sensing element has an indicating electrode that is adapted to be activated by electric power and to form a raw analyte measurement, when it is activated and in contact with the body fluid, in less than two minutes. The sensing device further has a reference electrode and an electric power and display device that is adapted to mate to the analyte-sensing element. The power and display device activates the analyte-sensing element by applying electric power to it. The analyte-sensing element is introduced into the animal body and is activated by the electric power and display device, thereby causing the analyte-sensing element to form a raw analyte measurement. The power and display device forms and displays a second analyte measurement that is related to the raw analyte measurement, within two minutes of the analyte sensing element being introduced into the body.

摘要翻译： 一种测量具有包括体液的皮肤和皮下软组织的动物体内的体液中的分析物浓度的方法。 该方法包括将分析物测量装置的一部分引入皮下软组织。 分析物测量装置包括分析物传感元件，具有锋利的远端以便于引入动物体内。 此外，感测元件具有适于通过电力激活并且在不到两分钟内被激活并与体液接触时形成原始分析物测量的指示电极。 感测装置还具有参考电极和适于与分析物感测元件配合的电力和显示装置。 功率和显示装置通过向其施加电力来激活分析物感测元件。 分析物感测元件被引入动物体内并被电力和显示装置激活，从而使分析物感测元件形成原始分析物测量。 功率和显示装置在分析物感测元件被引入体内的两分钟内形成并显示与原始分析物测量相关的第二分析物测量。

公开(公告)号：US09615851B2

公开(公告)日：2017-04-11

申请号：US13415828

申请日：2012-03-08

申请人： Mark Neinast ,  Robert Bruce ,  W. Kenneth Ward ,  Richard G. Sass ,  Jon Fortuna

发明人： Mark Neinast ,  Robert Bruce ,  W. Kenneth Ward ,  Richard G. Sass ,  Jon Fortuna

IPC分类号： A61B5/145 ,  A61B5/1473 ,  A61B17/34 ,  A61B5/00

CPC分类号： A61B5/6849 ,  A61B5/14532 ,  A61B5/1473 ,  A61B17/3403 ,  A61B17/3468

摘要： A device and method for delivering a device such as a sensor or fluid transport structure or a fluid transport structure sensor combination into, for example, mammalian skin. Such a device allows a sensor to penetrate mammalian skin without the use of an introducer device such as a needle. A device in accordance with embodiments of the present disclosure includes a housing for attachment to mammalian skin including an exit port for receiving the distal end of a biosensor and an injection activation device including a mechanism for forcing the sensing device from a first position within the housing, through the exit port to a second position, with sufficiently high velocity to partially penetrate the mammalian skin.

公开(公告)号：US20110282172A1

公开(公告)日：2011-11-17

申请号：US13127708

申请日：2009-11-09

申请人： Richard G. Sass

发明人： Richard G. Sass

IPC分类号： A61B5/1468 ,  A61B5/145

CPC分类号： A61B5/14865 ,  A61B5/076 ,  A61B5/14532

摘要： Embodiments provide an analyte sensing device having one or more indicating electrodes adapted for long-term use within an individual. An indicating electrode coupled with a reference electrode may be inserted within or below the dermis of an individual and may be electrically coupled to an external sensor unit. Related analyte sensor insertion aids and methods of using the disclosed embodiments are also provided.

摘要翻译： 实施例提供了具有适于在个体内长期使用的一个或多个指示电极的分析物感测装置。 与参考电极耦合的指示电极可以插入到个体的真皮内或下面，并且可以电耦合到外部传感器单元。 还提供了相关的分析物传感器插入辅助器和使用所公开的实施例的方法。