公开(公告)号：US11786581B2

公开(公告)日：2023-10-17

申请号：US17105156

申请日：2020-11-25

Applicant: Wake Forest University Health Sciences

Inventor： James Yoo ,  Sang Jin Lee ,  Anthony Atala ,  Mark Van Dyke

IPC: A61K9/00 ,  A61K38/39 ,  A61K38/48 ,  A61L27/24 ,  A61L27/52 ,  A61L27/54

CPC classification number: A61K38/39 ,  A61K9/0024 ,  A61K38/4886 ,  A61L27/24 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/434 ,  A61L2400/06 ,  A61L2430/26 ,  A61K38/39 ,  A61K2300/00 ,  A61K38/4886 ,  A61K2300/00

Abstract: The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.

公开(公告)号：US20210162017A1

公开(公告)日：2021-06-03

申请号：US17105156

申请日：2020-11-25

Applicant: Wake Forest University Health Sciences

Inventor： James YOO ,  Sang Jin Lee ,  Anthony Atala ,  Mark Van Dyke

IPC: A61K38/39 ,  A61K9/00 ,  A61K38/48 ,  A61L27/24 ,  A61L27/52 ,  A61L27/54

Abstract: The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.

公开(公告)号：US20180140678A1

公开(公告)日：2018-05-24

申请号：US15640063

申请日：2017-06-30

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： James Yoo ,  Sang Jin Lee ,  Anthony Atala ,  Mark Van Dyke

IPC: A61K38/39 ,  A61K38/48 ,  A61L27/24 ,  A61L27/52 ,  A61K9/00 ,  A61L27/54

CPC classification number: A61K38/39 ,  A61K9/0024 ,  A61K38/4886 ,  A61L27/24 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/434 ,  A61L2400/06 ,  A61L2430/26 ,  A61K2300/00

Abstract: The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.