公开(公告)号：US20190153057A1

公开(公告)日：2019-05-23

申请号：US16262195

申请日：2019-01-30

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： WALDEMAR DEBINSKI ,  HETAL PANDYA ,  DENISE GIBO

IPC: C07K14/54 ,  C07K19/00 ,  A61K47/64 ,  C07K14/21 ,  C07K14/34 ,  G01N33/50 ,  G01N33/532 ,  G01N33/68 ,  C07K14/005 ,  C07K14/195

CPC classification number: C07K14/5437 ,  A61K38/00 ,  A61K47/642 ,  C07K14/005 ,  C07K14/195 ,  C07K14/21 ,  C07K14/34 ,  C07K19/00 ,  C07K2319/01 ,  C07K2319/09 ,  C07K2319/74 ,  G01N33/5008 ,  G01N33/5091 ,  G01N33/532 ,  G01N33/6869 ,  G01N2333/025 ,  G01N2333/195 ,  G01N2333/5437

Abstract: A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.