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    Collar assembly for printer fusing system
    2.
    发明申请
    Collar assembly for printer fusing system 有权
    打印机定影系统的领子组件

    公开(公告)号：US20060153606A1

    公开(公告)日：2006-07-13

    申请号：US11031744

    申请日：2005-01-07

    申请人： Wade Eichhorn ,  Keith Murphy ,  Boris Avrushchenko ,  Kristian Wyrobek ,  Richard Duda

    发明人： Wade Eichhorn ,  Keith Murphy ,  Boris Avrushchenko ,  Kristian Wyrobek ,  Richard Duda

    IPC分类号： G03G15/20

    CPC分类号： G03G15/2053

    摘要： An apparatus and method for stabilizing a fuser in an imaging apparatus. The apparatus includes a hub having a body. The body comprises an outside diameter configured to be at least partially disposed inside an end of a fuser core. The apparatus also includes an elastomeric collar having an inside diameter, wherein the inside diameter is at least partially disposed over the outside diameter of the hub.

    摘要翻译： 一种用于稳定成像装置中的定影器的装置和方法。 该装置包括具有主体的轮毂。 本体包括被配置为至少部分地设置在定影器芯的端部内部的外径。 该装置还包括具有内径的弹性体轴环，其中内径至少部分地设置在毂的外径上。

    CAUSAL THERAPY OF DISEASES OR CONDITIONS ASSOCIATED WITH CNS OR PNS DEMYELINATION
    3.
    发明申请
    CAUSAL THERAPY OF DISEASES OR CONDITIONS ASSOCIATED WITH CNS OR PNS DEMYELINATION 有权
    与CNS或PNS相关的疾病或病症的原因治疗

    公开(公告)号：US20120269762A1

    公开(公告)日：2012-10-25

    申请号：US13503105

    申请日：2010-10-22

    申请人： Mark Pickering ,  Keith Murphy

    发明人： Mark Pickering ,  Keith Murphy

    IPC分类号： A61K31/4015 ,  A61P25/00 ,  A61K38/21 ,  A61K31/785 ,  A61K31/454 ,  A61K39/395

    CPC分类号： A61K31/4025

    摘要： The invention broadly relates to the use of the Active in the causal treatment of a disease caused by axonal demyelination, in which the Active maintains the integrity of myelination (for example by promoting remyelination, and/or preventing demyelination, of the axonal sheaths). The invention is particularly directed to the causal treatment of CNS demyelination diseases, for example MS, especially primary progressive MS and/or relapse remitting MS, and PNS demyelination diseases, for example Charcot-Marie-Tooth Disease. The Active of the invention may be suitably administered when a patient is in relapse (i.e. upon relapse), and be continued while the patient is in relapse, with a view to attenuating the severity of the relapse, and/or accelerating disease remission. Alternatively, the Active may be administered continuously with a view to prolonging the remission period, and/or attenuating the severity of the relapse, and/or preventing relapse. The invention also relates to the use of the Active as a treatment for symptoms of demyelination disease, especially MS, selected from vision deficits, motor control deficits, and sensation deficits.

    摘要翻译： 本发明广泛地涉及活性物质在由轴突脱髓鞘引起的疾病的病因治疗中的用途，其中活性物质保持髓鞘形成的完整性（例如通过促进轴突鞘的再髓鞘化和/或预防脱髓鞘化）。 本发明特别涉及CNS脱髓鞘疾病的病因治疗，例如MS，特别是原发性进行性MS和/或复发缓解MS，以及PNS脱髓鞘疾病，例如Charcot-Marie-Tooth Disease。 本发明的活性可以在患者复发时（即复发时）适当地施用，并且在患者复发期间继续进行，以减轻复发的严重性和/或加速疾病缓解。 或者，可以持续施用活性物质，以期延长缓解期，和/或减弱复发的严重性和/或预防复发。 本发明还涉及活性物质作为治疗脱髓鞘疾病症状的用途，特别是选自视力缺陷，运动障碍缺陷和感觉缺陷的MS。

    DEVICES, SYSTEMS, AND METHODS FOR THE FABRICATION OF TISSUE
    4.
    发明申请
    DEVICES, SYSTEMS, AND METHODS FOR THE FABRICATION OF TISSUE 有权
    用于制造组织的装置，系统和方法

    公开(公告)号：US20120116568A1

    公开(公告)日：2012-05-10

    申请号：US13246428

    申请日：2011-09-27

    申请人： Keith Murphy ,  Scott Dorfman ,  Nathan Smith ,  Larry Bauwens ,  Ian Sohn ,  Tim McDonald ,  Chris Leigh-Lancaster ,  Richard Jin Law

    发明人： Keith Murphy ,  Scott Dorfman ,  Nathan Smith ,  Larry Bauwens ,  Ian Sohn ,  Tim McDonald ,  Chris Leigh-Lancaster ,  Richard Jin Law

    IPC分类号： B05C5/00 ,  G06F17/00 ,  B65G47/24 ,  B05C11/00

    CPC分类号： A61L27/3808 ,  A61L27/3826 ,  B01L3/0268 ,  B28B1/001 ,  B29C64/106 ,  B29C64/112 ,  B29C64/118 ,  B29C64/20 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y70/00 ,  B41J3/407 ,  C12M21/08 ,  C12M33/00

    摘要： Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.

    摘要翻译： 本文描述的生物打印机包括：一个或多个打印头，其中打印头包括用于接收和保持至少一个盒的装置，并且其中所述盒包括从以下中的一个或多个选择的内容：生物油墨和支撑材料; 用于校准至少一个盒的位置的装置; 以及用于分配至少一个盒的内容物的装置。 本文进一步描述的是用于制造组织结构的方法，包括：计算机模块，其接收所需组织结构的视觉表示的输入; 生成一系列命令的计算机模块，其中所述命令基于所述视觉表示，并且可由生物打印机读取; 为生物打印机提供一系列命令的计算机模块; 并且生物印刷机根据命令沉积生物油墨和支撑材料以形成具有确定的几何形状的构造。

    Causal therapy of diseases or conditions associated with CNS or PNS demyelination
    5.
    发明授权
    Causal therapy of diseases or conditions associated with CNS or PNS demyelination 有权
    与CNS或PNS脱髓鞘相关的疾病或病症的原因治疗

    公开(公告)号：US08962676B2

    公开(公告)日：2015-02-24

    申请号：US13503105

    申请日：2010-10-22

    申请人： Mark Pickering ,  Keith Murphy

    发明人： Mark Pickering ,  Keith Murphy

    IPC分类号： A61K31/4025

    CPC分类号： A61K31/4025

    摘要： The present invention is directed to the treatment of demyelination as an underlying cause of the disease of multiple sclerosis (MS) in a mammal, the method comprising promoting remyelination of myelination of axonal cells by administering to the mammal a 2-oxopyrrolidine compound having a general formula I: wherein R═R′═H, and R″═CH2CONH-(2,6CH3)C6H3 or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及治疗脱髓鞘作为哺乳动物多发性硬化症（MS）疾病的根本原因，该方法包括通过向哺乳动物施用具有一般性的2-氧代吡咯烷化合物来促进轴突细胞髓鞘形成髓鞘化 式I：其中R = R'= H，和R“= CH 2 CONH-（2,6CH 3）C 6 H 3或其药学上可接受的盐。

    MULTILAYERED VASCULAR TUBES
    8.
    发明申请
    MULTILAYERED VASCULAR TUBES 审中-公开
    多层血管

    公开(公告)号：US20130345794A1

    公开(公告)日：2013-12-26

    申请号：US13634863

    申请日：2011-03-16

    申请人： Chirag Khatiwala ,  Keith Murphy ,  Benjamin Shepherd

    发明人： Chirag Khatiwala ,  Keith Murphy ,  Benjamin Shepherd

    IPC分类号： A61F2/06

    CPC分类号： A61F2/06 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/3826 ,  A61L27/507 ,  C12N5/0691 ,  C12N2502/1323 ,  C12N2533/76

    摘要： Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold. Also described herein are methods of forming said tubes and uses for said tubes including methods for treating patients, comprising providing such a tube into to a patient in need thereof.

    摘要翻译： 本文描述的是包含至少一层分化成体成纤维细胞，至少一层分化成年平滑肌细胞的工程多层血管，其中任何层还包含分化的成体内皮细胞，其中所述管具有以下特征：（a） 内皮细胞与平滑肌细胞的比例约为1:99至约45:55; （b）管是顺从的; （c）管的内径约为6mm或更小; （d）管的长度可达约30厘米; 和（e）管的厚度沿管的区域基本均匀; 条件是工程多层血管管不含任何预先形成的支架。 本文还描述了形成所述管的方法和用于所述管的方法，包括用于治疗患者的方法，包括将这种管提供给有需要的患者。

    METHODS FOR IDENTIFICATION OF ALPORT SYNDROME
    10.
    发明申请
    METHODS FOR IDENTIFICATION OF ALPORT SYNDROME 有权
    鉴别ALPORT SYNDROME的方法

    公开(公告)号：US20070243538A1

    公开(公告)日：2007-10-18

    申请号：US11423650

    申请日：2006-06-12

    申请人： Keith Murphy ,  Ashley Davidson ,  George Lees

    发明人： Keith Murphy ,  Ashley Davidson ,  George Lees

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： Animals with mutations in COL4α4 present with autosomal recessive Alport Syndrome (ARAS). Through sequencing of COL4α4, the mutation causative for ARAS in the English Cocker Spaniel (ECS) has been identified. The resulting protein is severely truncated due to a premature stop codon in exon 3. This nonsense mutation occurs in the 7S domain and also causes the loss of the entire collagenous and NC1 domains of the protein. Methods for the identification of animals that harbor a mutation in the COL4α4 gene are described. Mutations in the COL4α4 gene can be identified from any biological sample such as a cell or tissue that contains genomic DNA. Methods for identifying single nucleotide polymorphisms (SNPs) that are inherited with the disease are also described. A microsatellite marker that segregates with ARAS is also described that was identified using linkage disequilibrium mapping.

    摘要翻译： 具有常染色体隐性遗传综合征（ARAS）的COL4α4突变的动物。 通过COL4alpha4的测序，确定了英国可卡犬（ECS）中ARAS的突变致病因子。 所得蛋白质由于外显子3中的过早终止密码子而严重截断。这种无义突变发生在7S结构域中，并且还导致蛋白质的整个胶原和NC1结构域的损失。 描述了在COL4alpha4基因中鉴定携带突变的动物的方法。 COL4alpha4基因的突变可以从任何生物样品（如含有基因组DNA的细胞或组织）鉴定。 还描述了用于鉴定与该疾病遗传的单核苷酸多态性（SNP）的方法。 还描述了用ARAS分离的微卫星标记，其使用连锁不平衡作图来鉴定。