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    Phosphono-carboxylate compounds for treating amyloidosis
    7.
    发明授权
    Phosphono-carboxylate compounds for treating amyloidosis 失效
    用于治疗淀粉样变性的膦酰羧酸盐化合物

    公开(公告)号：US06440952B2

    公开(公告)日：2002-08-27

    申请号：US09860255

    申请日：2001-05-17

    申请人： Walter A. Szarek ,  Xianqi Kong ,  Gregory R. J. Thatcher ,  Boris Gorine

    发明人： Walter A. Szarek ,  Xianqi Kong ,  Gregory R. J. Thatcher ,  Boris Gorine

    IPC分类号： A61K3166

    CPC分类号： A61K31/662 ,  A61K31/66 ,  A61K31/675

    摘要： Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.

    摘要翻译： 描述了治疗化合物和调节受试者淀粉样蛋白沉积的方法，无论其临床情况如何。 通过施用有效量的包含膦酸酯基和羧酸酯基的治疗化合物，其同类物或其药学上可接受的盐或酯来调节淀粉样蛋白沉积。 在优选的实施方案中，调节淀粉样蛋白形成蛋白质与基底膜成分之间的相互作用。

    Phosphono-carboxylate compounds for treating amyloidosis
    9.
    发明授权
    Phosphono-carboxylate compounds for treating amyloidosis 失效

    公开(公告)号：US06329356B1

    公开(公告)日：2001-12-11

    申请号：US09288583

    申请日：1999-04-08

    申请人： Walter A. Szarek ,  Xianqi Kong

    发明人： Walter A. Szarek ,  Xianqi Kong

    IPC分类号： A61K3166

    CPC分类号： A61K31/662 ,  A61K31/66 ,  A61K31/675

    摘要： Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.

    Phosphonocarboxylate compounds for treating amyloidosis
    10.
    发明授权
    Phosphonocarboxylate compounds for treating amyloidosis 失效
    用于治疗淀粉样变性的膦酰化物化合物

    公开(公告)号：US5869469A

    公开(公告)日：1999-02-09

    申请号：US912574

    申请日：1997-08-18

    申请人： Walter A. Szarek ,  Xianqi Kong

    发明人： Walter A. Szarek ,  Xianqi Kong

    IPC分类号： A61K31/675 ,  C07F9/40 ,  A61K31/66

    CPC分类号： A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  C07F9/4065

    摘要： Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.

    摘要翻译： 描述了治疗化合物和调节受试者淀粉样蛋白沉积的方法，无论其临床情况如何。 通过给予受试者调节淀粉样蛋白沉积，所述有效量的包含膦酸酯基和羧酸酯基的治疗化合物或其药学上可接受的盐或酯。 在优选的实施方案中，调节淀粉样蛋白形成蛋白质与基底膜成分之间的相互作用。