专利检索 ap:("Walter C. Babcock" OR "William J. Curatolo" OR "Dwayne T. Friesen" OR "Rodney J. Ketner" OR "Julian B. Lo" OR "James A. S. Nightingale" OR "Ravi M. Shanker" OR "James B. West") AND inv:"William J. Curatolo" 第 1 页

1.

发明申请
Pharmaceutical Compositions of Dispersions of Amorphous Drugs Mixed with Polymers 有权
标题翻译：与聚合物混合的无定形药物分散体的药物组合物

公开(公告)号：US20120295988A1

公开(公告)日：2012-11-22

申请号：US13563536

申请日：2012-07-31

申请人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West

发明人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West

IPC分类号： A61K47/38 , A61P25/22 , A61P7/02 , A61P25/08 , A61P25/28 , A61P35/00 , A61P29/00 , A61P25/18 , A61P3/04 , A61P31/04 , A61P9/12 , A61P11/14

CPC分类号： A61K9/146

摘要： A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.

摘要翻译： 药物组合物包含包含低溶解度药物和与浓度增强聚合物组合的基质的分散体。至少大部分药物在分散体中是无定形的。组合物改善药物在分散体中的稳定性和/或药物在使用环境中的浓度。

2.

发明授权
Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers 有权
标题翻译：与聚合物混合的无定形药物的分散体的药物组合物

公开(公告)号：US08236328B2

公开(公告)日：2012-08-07

申请号：US12217700

申请日：2008-07-08

申请人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West

发明人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West

IPC分类号： A61K9/00 , A61K9/14

CPC分类号： A61K9/146

摘要： A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.

摘要翻译： 药物组合物包含包含低溶解度药物和与浓度增强聚合物组合的基质的分散体。至少大部分药物在分散体中是无定形的。组合物改善药物在分散体中的稳定性和/或药物在使用环境中的浓度。

3.

发明授权
Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers 有权
标题翻译：与聚合物混合的无定形药物的分散体的药物组合物

公开(公告)号：US08703196B2

公开(公告)日：2014-04-22

申请号：US13563536

申请日：2012-07-31

申请人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West

发明人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West

IPC分类号： A61K9/14 , A61K47/38

CPC分类号： A61K9/146

摘要： A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.

摘要翻译： 药物组合物包含包含低溶解度药物和与浓度增强聚合物组合的基质的分散体。至少大部分药物在分散体中是无定形的。组合物改善药物在分散体中的稳定性和/或药物在使用环境中的浓度。

4.

发明申请
Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers 有权
标题翻译：与聚合物混合的无定形药物的分散体的药物组合物

公开(公告)号：US20090011024A1

公开(公告)日：2009-01-08

申请号：US12217700

申请日：2008-07-08

申请人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A.S. Nightingale , Ravi M. Shanker , James B. West

发明人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A.S. Nightingale , Ravi M. Shanker , James B. West

IPC分类号： A61K9/10 , A61K31/4706

CPC分类号： A61K9/146

摘要： A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.

摘要翻译： 药物组合物包含包含低溶解度药物和与浓度增强聚合物组合的基质的分散体。至少大部分药物在分散体中是无定形的。组合物改善药物在分散体中的稳定性和/或药物在使用环境中的浓度。

5.

发明授权
Pharmaceutical compositions providing enhanced drug concentrations 有权
标题翻译：提供增强药物浓度的药物组合物

公开(公告)号：US08202912B2

公开(公告)日：2012-06-19

申请号：US13208305

申请日：2011-08-11

申请人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz

发明人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz

IPC分类号： A61K47/32 , A61K9/14 , A61K9/16 , A61K9/22

CPC分类号： A61K47/38 , A61K9/146 , A61K9/1629 , A61K9/1652 , A61K31/135 , A61K31/404 , A61K31/4178 , A61K31/4375 , A61K31/496 , A61K31/517

摘要： A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.

摘要翻译： 将溶解度改善形式的药物与足够量的浓度增强聚合物组合，使得组合在使用环境中相对于包含相同量的相同溶解度改善形式的药物的对照提供了显着增强的药物浓度没有浓度增强聚合物。

6.

发明授权
Pharmaceutical compositions providing enhanced drug concentrations 有权
标题翻译：提供增强药物浓度的药物组合物

公开(公告)号：US08026286B2

公开(公告)日：2011-09-27

申请号：US09742785

申请日：2000-12-20

申请人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz

发明人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz

IPC分类号： A61K47/32 , A61K9/14 , A61K9/16 , A61K9/22

CPC分类号： A61K47/38 , A61K9/146 , A61K9/1629 , A61K9/1652 , A61K31/135 , A61K31/404 , A61K31/4178 , A61K31/4375 , A61K31/496 , A61K31/517

摘要： A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.

摘要翻译： 将溶解度改善形式的药物与足够量的浓度增强聚合物组合，使得组合在使用环境中相对于包含相同量的相同溶解度改善形式的药物的对照提供了显着增强的药物浓度没有浓度增强聚合物。

7.

发明授权
Pharmaceutical compositions providing enhanced drug concentrations 有权

公开(公告)号：US08501231B2

公开(公告)日：2013-08-06

申请号：US13527536

申请日：2012-06-19

申请人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz

发明人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz

IPC分类号： A61K9/14 , A61K9/16 , A61K9/22 , A61K47/32

CPC分类号： A61K47/38 , A61K9/146 , A61K9/1629 , A61K9/1652 , A61K31/135 , A61K31/404 , A61K31/4178 , A61K31/4375 , A61K31/496 , A61K31/517

摘要： A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.

8.

发明申请
PHARMACEUTICAL COMPOSITIONS PROVIDING ENHANCED DRUG CONCENTRATIONS 有权
标题翻译：提供增强药物浓度的药物组合物

公开(公告)号：US20120259022A1

公开(公告)日：2012-10-11

申请号：US13527536

申请日：2012-06-19

申请人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz

发明人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz

IPC分类号： A61K47/38 , A61K47/40 , A61P9/12 , A61P25/22 , A61P25/28 , A61P25/08 , A61P11/14 , A61P35/00 , A61P25/20 , A61P3/04 , A61K47/32 , A61P7/02

CPC分类号： A61K47/38 , A61K9/146 , A61K9/1629 , A61K9/1652 , A61K31/135 , A61K31/404 , A61K31/4178 , A61K31/4375 , A61K31/496 , A61K31/517

摘要： A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.

摘要翻译： 将溶解度改善形式的药物与足够量的浓度增强聚合物组合，使得组合在使用环境中相对于包含相同量的相同溶解度改善形式的药物的对照提供了显着增强的药物浓度没有浓度增强聚合物。