公开(公告)号：US5616685A

公开(公告)日：1997-04-01

申请号：US319503

申请日：1994-10-06

申请人： Walter J. Van Venrooij ,  Peter T. G. Sillekens ,  Winand J. A. Habets

发明人： Walter J. Van Venrooij ,  Peter T. G. Sillekens ,  Winand J. A. Habets

IPC分类号： G01N33/564 ,  A61K38/00 ,  A61K39/395 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  G01N33/58 ,  C07K7/52 ,  A61K39/00 ,  C07K9/00

CPC分类号： C07K14/4713 ,  A61K38/00

摘要： The present invention relates to a protein antigen which is reactive towards an auto-antibody which is associated with an auto-immune disease, and the use of this protein in diagnostic tests relating to auto-immune diseases.

摘要翻译： 本发明涉及对与自身免疫疾病相关的自身抗体具有反应性的蛋白质抗原，以及该蛋白质在与自身免疫疾病相关的诊断测试中的应用。

公开(公告)号：US08106172B2

公开(公告)日：2012-01-31

申请号：US10559949

申请日：2004-03-08

申请人： Peter T. G. Sillekens ,  Marlieke Overdijk ,  Saskia van de Laar

发明人： Peter T. G. Sillekens ,  Marlieke Overdijk ,  Saskia van de Laar

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/701 ,  C12Q2531/113 ,  C12Q2531/143 ,  C12Q2561/101

摘要： The present invention is related to nucleic acid sequences that can be used in the field of virus diagnostics, more specifically the diagnosis of infections with a novel human coronavirus causing Severe Acute Respiratory Syndrome (SARS). With the present invention nucleotide sequences are provided that can be used as primers and probes in the amplification and detection of SARS nucleic acid. The oligonucleotide sequences provided with the present invention are located in the replicase gene, the nucleocapsid gene and the 3′ end non-coding region of the SARS Coronavirus genome. It has been found that, by using the sequences of the present invention in methods for the amplification and detection of nucleic acid a sensitive and specific detection of SARS Coronavirus can be obtained. The oligonucleotide sequences according to the present invention are especially useful in methods for the amplification of nucleic acid.

摘要翻译： 本发明涉及可用于病毒诊断领域的核酸序列，更具体地说，涉及引起严重急性呼吸综合征（SARS）的新型人冠状病毒感染的诊断。 本发明提供了可用作扩增和检测SARS核酸的引物和探针的核苷酸序列。 本发明提供的寡核苷酸序列位于SARS冠状病毒基因组的复制酶基因，核衣壳基因和3'端非编码区。 已经发现，通过将本发明的序列用于扩增和检测核酸的方法，可以获得SARS的敏感和特异性检测冠状病毒。 根据本发明的寡核苷酸序列特别可用于扩增核酸的方法。