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    Method of inducing memory B cell development and terminal differentiation
    1.
    发明授权
    Method of inducing memory B cell development and terminal differentiation 有权
    诱导记忆B细胞发育和终末分化的方法

    公开(公告)号：US07993919B2

    公开(公告)日：2011-08-09

    申请号：US10579988

    申请日：2004-11-18

    申请人： Warren J. Leonard ,  Peter Lipsky ,  Herbert C. Morse, III ,  Catherine Rachel Ettinger ,  Rosanne Spolski

    发明人： Warren J. Leonard ,  Peter Lipsky ,  Herbert C. Morse, III ,  Catherine Rachel Ettinger ,  Rosanne Spolski

    IPC分类号： C12N5/00 ,  C12N5/071

    CPC分类号： G01N33/5052 ,  A61K35/17 ,  A61K38/20 ,  A61K2035/124 ,  A61K2039/5158 ,  C12N5/0635 ,  C12N2501/052 ,  C12N2501/23 ,  C12N2501/50 ,  C12N2501/52 ,  G01N2333/54

    摘要： A method is disclosed herein for inducing differentiation of a B cell progenitor into a memory B cells and/or a plasma cell. The method includes contacting a population of cells including a mature B cell or a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. In one embodiment, the B cell progenitor is an immature B cell. A method is also disclosed for enhancing an immune response. The method includes contacting a population of cells including a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. The memory B cells arid/or the plasma cell are then introduced into the subject to enhance the immune response. A method is also disclosed for treating a subject with a condition comprising a specific deficiency of at least one of memory B cells and plasma cells. A method is disclosed for identifying an agent with a physiological effect on one or more of a memory B cell and a plasma cell differentiation. A method is also disclosed for identifying agents that inhibit an activity of IL-21.

    摘要翻译： 本文公开了一种用于诱导B细胞祖细胞分化为记忆B细胞和/或浆细胞的方法。 该方法包括使包含成熟B细胞或B细胞祖细胞的细胞群与有效量的IL-21接触，并分离记忆B细胞或浆细胞。 在一个实施方案中，B细胞祖细胞是未成熟B细胞。 还公开了一种用于增强免疫应答的方法。 该方法包括使包含B细胞祖细胞的细胞群与有效量的IL-21接触，并分离记忆B细胞或浆细胞。 然后将记忆B细胞和/或浆细胞引入受试者以增强免疫应答。 还公开了一种用于治疗患有包含存储B细胞和浆细胞中的至少一种的特定缺陷的病症的受试者的方法。 公开了用于鉴定对存储B细胞和浆细胞分化中的一种或多种具有生理作用的药剂的方法。 还公开了用于鉴定抑制IL-21活性的试剂的方法。

    METHOD OF INDUCING MEMORY B CELL DEVELOPMENT AND TERMINAL DIFFERENTIATION
    3.
    发明申请
    METHOD OF INDUCING MEMORY B CELL DEVELOPMENT AND TERMINAL DIFFERENTIATION 有权
    诱导记忆B细胞发育和终末分化的方法

    公开(公告)号：US20080305076A1

    公开(公告)日：2008-12-11

    申请号：US12126166

    申请日：2008-05-23

    申请人： Catherine Rachel Ettinger ,  Peter E. Lipsky ,  Warren J. Leonard ,  Rosanne Spolski ,  Herbert C. Morse, III

    发明人： Catherine Rachel Ettinger ,  Peter E. Lipsky ,  Warren J. Leonard ,  Rosanne Spolski ,  Herbert C. Morse, III

    IPC分类号： A61K38/20 ,  C12Q1/02 ,  C40B30/06 ,  A61K48/00 ,  A61K31/711 ,  G01N33/567 ,  C12N5/06

    CPC分类号： G01N33/5052 ,  A61K35/17 ,  A61K38/20 ,  A61K2035/124 ,  A61K2039/5158 ,  C12N5/0635 ,  C12N2501/052 ,  C12N2501/23 ,  C12N2501/50 ,  C12N2501/52 ,  G01N2333/54

    摘要： A method is disclosed herein for inducing differentiation of a B cell progenitor into a memory B cells and/or a plasma cell. The method includes contacting a population of cells including a mature B cell or a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. In one embodiment, the B cell progenitor is an immature B cell. A method is also disclosed for enhancing an immune response. The method includes contacting a population of cells including a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. The memory B cells and/or the plasma cell are then introduced into the subject to enhance the immune response. A method is also disclosed for treating a subject with a condition comprising a specific deficiency of at least one of memory B cells and plasma cells. A method is disclosed for identifying an agent with a physiological effect on one or more of a memory B cell and a plasma cell differentiation. A method is also disclosed for identifying agents that inhibit an activity of IL-21. Methods are also disclosed for inducing apoptosis of a B cell and for decreasing the number of B cells. A method is also described for producing a B cell hybridoma.

    摘要翻译： 本文公开了一种用于诱导B细胞祖细胞分化为记忆B细胞和/或浆细胞的方法。 该方法包括使包含成熟B细胞或B细胞祖细胞的细胞群与有效量的IL-21接触，并分离记忆B细胞或浆细胞。 在一个实施方案中，B细胞祖细胞是未成熟B细胞。 还公开了一种用于增强免疫应答的方法。 该方法包括使包含B细胞祖细胞的细胞群与有效量的IL-21接触，并分离记忆B细胞或浆细胞。 然后将记忆B细胞和/或浆细胞引入受试者以增强免疫应答。 还公开了一种用于治疗患有包含存储B细胞和浆细胞中的至少一种的特定缺陷的病症的受试者的方法。 公开了用于鉴定对存储B细胞和浆细胞分化中的一种或多种具有生理作用的药剂的方法。 还公开了用于鉴定抑制IL-21活性的试剂的方法。 还公开了诱导B细胞凋亡和减少B细胞数量的方法。 还描述了用于产生B细胞杂交瘤的方法。

    Method of inducing memory B cell development and terminal differentiation
    4.
    发明授权
    Method of inducing memory B cell development and terminal differentiation 有权
    诱导记忆B细胞发育和终末分化的方法

    公开(公告)号：US07378276B2

    公开(公告)日：2008-05-27

    申请号：US11197221

    申请日：2005-08-03

    申请人： Catherine Rachel Ettinger ,  Peter E. Lipsky ,  Warren J. Leonard ,  Rosanne Spolski ,  Herbert C. Morse, III

    发明人： Catherine Rachel Ettinger ,  Peter E. Lipsky ,  Warren J. Leonard ,  Rosanne Spolski ,  Herbert C. Morse, III

    IPC分类号： C12N5/02 ,  C12N5/08 ,  A01N37/18 ,  C07K1/00

    CPC分类号： G01N33/5052 ,  A61K35/17 ,  A61K38/20 ,  A61K2035/124 ,  A61K2039/5158 ,  C12N5/0635 ,  C12N2501/052 ,  C12N2501/23 ,  C12N2501/50 ,  C12N2501/52 ,  G01N2333/54

    摘要： A method is disclosed herein for inducing differentiation of a B cell progenitor into a memory B cells and/or a plasma cell. The method includes contacting a population of cells including a mature B cell or a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. In one embodiment, the B cell progenitor is an immature B cell. A method is also disclosed for enhancing an immune response. The method includes contacting a population of cells including a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. The memory B cells and/or the plasma cell are then introduced into the subject to enhance the immune response. A method is also disclosed for treating a subject with a condition comprising a specific deficiency of at least one of memory B cells and plasma cells. A method is disclosed for identifying an agent with a physiological effect on one or more of a memory B cell and a plasma cell differentiation. A method is also disclosed for identifying agents that inhibit an activity of IL-21. Methods are also disclosed for inducing apoptosis of a B cell and for decreasing the number of B cells. A method is also described for producing a B cell hybridoma.

    摘要翻译： 本文公开了一种用于诱导B细胞祖细胞分化为记忆B细胞和/或浆细胞的方法。 该方法包括使包含成熟B细胞或B细胞祖细胞的细胞群与有效量的IL-21接触，并分离记忆B细胞或浆细胞。 在一个实施方案中，B细胞祖细胞是未成熟的B细胞。 还公开了一种用于增强免疫应答的方法。 该方法包括使包含B细胞祖细胞的细胞群与有效量的IL-21接触，并分离记忆B细胞或浆细胞。 然后将记忆B细胞和/或浆细胞引入受试者以增强免疫应答。 还公开了一种用于治疗患有包含存储B细胞和浆细胞中的至少一种的特定缺陷的病症的受试者的方法。 公开了用于鉴定对存储B细胞和浆细胞分化中的一种或多种具有生理作用的药剂的方法。 还公开了用于鉴定抑制IL-21活性的试剂的方法。 还公开了诱导B细胞凋亡和减少B细胞数量的方法。 还描述了用于产生B细胞杂交瘤的方法。