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1.发明申请公开(公告)号：US20120259389A1
公开(公告)日：2012-10-11
申请号：US13445718
申请日：2012-04-12
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61B5/0006 , A61B5/14532 , A61B5/686 , A61N1/36085 , A61N1/36171 , A61N1/36175
摘要： In some examples, the disclosure relates to a systems, devices, and techniques for delivering electrical stimulation therapy to a patient. In some example, the disclosure relates to systems and methods of treating hyperglycemia in a patient including delivering gastric electrical stimulation (GES) to the patient. Devices, systems and methods according to the disclosure may comprise an implantable stimulator, a blood glucose monitor and/or a food intake sensor. In some examples, a blood glucose level and/or food intake of a patient is detected and GES is delivered to the patient in response to the detection.
摘要翻译： 在一些示例中，本公开涉及用于向患者递送电刺激治疗的系统，装置和技术。 在一些实例中，本公开涉及治疗患者的高血糖症的系统和方法，包括向患者输送胃电刺激（GES）。 根据本公开的装置，系统和方法可以包括可植入刺激器，血糖监测器和/或食物摄取传感器。 在一些示例中，检测到患者的血糖水平和/或食物摄取，并且响应于检测将GES递送给患者。
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2.发明申请公开(公告)号：US20090088818A1
公开(公告)日：2009-04-02
申请号：US12236852
申请日：2008-09-24
IPC分类号： A61N1/36
CPC分类号： A61N1/36007
摘要： The disclosure is directed to gastric stimulation programmers, stimulators and methods for controlling delivery of gastric stimulation therapy to maintain the efficacy of the therapy over time. Maintaining the efficacy of gastric stimulation therapy may be possible by implementing one or more anti-desensitization features in a gastric stimulation controller or stimulator. As electrical stimulation therapy is continuously delivered to a patient, the stimulated tissue may become desensitized to the electrical stimulation therapy such that the beneficial effect of the electrical stimulation is diminished. Once desensitization occurs, the affected tissue may not respond favorably to electrical stimulation therapy. Application of one or more anti-desensitization features to control gastric stimulation therapy may reduce or prevent desensitization and effectively extend the efficacy of the therapy over time.
摘要翻译： 本公开涉及胃刺激程序员，刺激剂和用于控制胃刺激治疗递送的方法，以保持治疗随时间的功效。 通过在胃刺激控制器或刺激器中实施一种或多种抗脱敏特征，可以维持胃刺激治疗的功效。 随着电刺激治疗被持续递送到患者，刺激的组织可能变得对电刺激疗法脱敏，使得电刺激的有益效果减弱。 一旦发生脱敏，受影响的组织可能不会有利于电刺激治疗。 应用一种或多种抗脱敏特征来控制胃刺激疗法可以减少或预防脱敏，并有效地延长治疗的疗效。
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公开(公告)号：US09937344B2
公开(公告)日：2018-04-10
申请号：US12887149
申请日：2010-09-21
申请人： Warren L. Starkebaum , Roland C. Maude-Griffin , Elizabeth D. Firestone , Carl A. Schu , Orhan Soykan
发明人： Warren L. Starkebaum , Roland C. Maude-Griffin , Elizabeth D. Firestone , Carl A. Schu , Orhan Soykan
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/36085 , A61N1/36171 , A61N1/36175
摘要： In some examples, the disclosure relates to a systems, devices, and techniques for delivering electrical stimulation therapy to a patient. In one example, the disclosure relates to a method including delivering a series of pulses with alternating pulse polarities to a gastrointestinal tract of a patient. The series of pulses includes at least a first pulse of a first polarity, a second pulse of a second polarity, and a third pulse of the first polarity, where the first, second and third pulses are delivered in direct succession and in that order. The first and second pulses are separated by a first time delay and the second and third pulses are separated by a second time delay. In some examples, each of the first and second time delays depend on the frequency that the series of pulses are delivered.
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4.发明申请公开(公告)号：US20100228313A1
公开(公告)日：2010-09-09
申请号：US12715993
申请日：2010-03-02
IPC分类号： A61N1/36
CPC分类号： A61F5/0026 , A61N1/36007
摘要： The disclosure is directed to techniques for delivering electrical stimulation therapy to support obesity management. The electrical stimulation therapy is configured to cause at least partial gastric distention. Gastric distention tends to induce a sensation of fullness and thereby discourages excessive food intake by the patient. The electrical stimulation therapy may be delivered to the gastrointestinal tract of the patient by electrodes deployed by one or more implantable leads coupled to an electrical stimulator. The electrical stimulator delivers stimulation pulses having a pulse width in a range found to be effective in causing gastric distention.
摘要翻译： 本公开涉及用于递送电刺激治疗以支持肥胖症管理的技术。 电刺激治疗被配置为引起至少部分胃膨胀。 胃膨胀往往会引起丰满感，从而阻止患者摄取过量食物。 电刺激治疗可以通过由耦合到电刺激器的一个或多个可植入引线部署的电极递送到患者的胃肠道。 电刺激器传送刺激脉冲，其脉冲宽度在发现有效引起胃膨胀的范围内。
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5.发明授权公开(公告)号：US08538532B2
公开(公告)日：2013-09-17
申请号：US12715993
申请日：2010-03-02
IPC分类号： A61N1/36
CPC分类号： A61F5/0026 , A61N1/36007
摘要： In some examples, electrical stimulation therapy is delivered to support obesity management. The electrical stimulation therapy is configured to cause at least partial gastric distention. Gastric distention tends to induce a sensation of fullness and thereby discourages excessive food intake by the patient. The electrical stimulation therapy may be delivered to the gastrointestinal tract of the patient by electrodes deployed by one or more implantable leads coupled to an electrical stimulator. The electrical stimulator delivers stimulation pulses having a pulse width in a range found to be effective in causing gastric distention.
摘要翻译： 在一些实例中，递送电刺激治疗以支持肥胖症管理。 电刺激治疗被配置为引起至少部分胃膨胀。 胃膨胀往往会引起丰满感，从而阻止患者摄取过量食物。 电刺激治疗可以通过由耦合到电刺激器的一个或多个可植入引线部署的电极递送到患者的胃肠道。 电刺激器传送刺激脉冲，其脉冲宽度在发现有效引起胃膨胀的范围内。
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6.发明授权公开(公告)号：US07983755B2
公开(公告)日：2011-07-19
申请号：US12236924
申请日：2008-09-24
IPC分类号： A61N1/36
CPC分类号： A61N1/36007
摘要： The disclosure is directed to gastric stimulation programmers, stimulators and methods for controlling delivery of gastric stimulation therapy to maintain the efficacy of the therapy over time. Maintaining the efficacy of gastric stimulation therapy may be possible by implementing one or more anti-desensitization features in a gastric stimulation controller or stimulator. As electrical stimulation therapy is continuously delivered to a patient, the stimulated tissue may become desensitized to the electrical stimulation therapy such that the beneficial effect of the electrical stimulation is diminished. Once desensitization occurs, the affected tissue may not respond favorably to electrical stimulation therapy. Application of one or more anti-desensitization features to control gastric stimulation therapy may reduce or prevent desensitization and effectively extend the efficacy of the therapy over time.
摘要翻译： 本公开涉及胃刺激程序员，刺激剂和用于控制胃刺激治疗递送的方法，以保持治疗随时间的功效。 通过在胃刺激控制器或刺激器中实施一种或多种抗脱敏特征，可以维持胃刺激治疗的功效。 随着电刺激治疗被持续递送到患者，刺激的组织可能变得对电刺激疗法脱敏，使得电刺激的有益效果减弱。 一旦发生脱敏，受影响的组织可能不会有利于电刺激治疗。 应用一种或多种抗脱敏特征来控制胃刺激疗法可以减少或预防脱敏，并有效地延长治疗的疗效。
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7.发明申请GASTRIC ELECTRICAL STIMULATION WITH LOCKOUT INTERVAL ANTI-DESENSITIZATION FEATURE 有权具有锁定间隔抗气孔特征的气路电刺激公开(公告)号：US20090088817A1
公开(公告)日：2009-04-02
申请号：US12236836
申请日：2008-09-24
IPC分类号： A61N1/36
CPC分类号： A61N1/36007
摘要： The disclosure is directed to gastric stimulation programmers, stimulators and methods for controlling delivery of gastric stimulation therapy to maintain the efficacy of the therapy over time. Maintaining the efficacy of gastric stimulation therapy may be possible by implementing one or more anti-desensitization features in a gastric stimulation controller or stimulator. As electrical stimulation therapy is continuously delivered to a patient, the stimulated tissue may become desensitized to the electrical stimulation therapy such that the beneficial effect of the electrical stimulation is diminished. Once desensitization occurs, the affected tissue may not respond favorably to electrical stimulation therapy. Application of one or more anti-desensitization features to control gastric stimulation therapy may reduce or prevent desensitization and effectively extend the efficacy of the therapy over time.
摘要翻译： 本公开涉及胃刺激程序员，刺激剂和用于控制胃刺激治疗递送的方法，以保持治疗随时间的功效。 通过在胃刺激控制器或刺激器中实施一种或多种抗脱敏特征，可以维持胃刺激治疗的功效。 随着电刺激治疗被持续递送到患者，刺激的组织可能变得对电刺激疗法脱敏，使得电刺激的有益效果减弱。 一旦发生脱敏，受影响的组织可能不会有利于电刺激治疗。 应用一种或多种抗脱敏特征来控制胃刺激疗法可以减少或预防脱敏，并有效地延长治疗的疗效。
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8.发明授权公开(公告)号：US09446234B2
公开(公告)日：2016-09-20
申请号：US12236836
申请日：2008-09-24
IPC分类号： A61N1/36
CPC分类号： A61N1/36007
摘要： The disclosure is directed to gastric stimulation programmers, stimulators and methods for controlling delivery of gastric stimulation therapy to maintain the efficacy of the therapy over time. Maintaining the efficacy of gastric stimulation therapy may be possible by implementing one or more anti-desensitization features in a gastric stimulation controller or stimulator. As electrical stimulation therapy is continuously delivered to a patient, the stimulated tissue may become desensitized to the electrical stimulation therapy such that the beneficial effect of the electrical stimulation is diminished. Once desensitization occurs, the affected tissue may not respond favorably to electrical stimulation therapy. Application of one or more anti-desensitization features to control gastric stimulation therapy may reduce or prevent desensitization and effectively extend the efficacy of the therapy over time.
摘要翻译： 本公开涉及胃刺激程序员，刺激剂和用于控制胃刺激治疗递送的方法，以保持治疗随时间的功效。 通过在胃刺激控制器或刺激器中实施一种或多种抗脱敏特征，可以维持胃刺激治疗的功效。 随着电刺激治疗被持续递送到患者，刺激的组织可能变得对电刺激疗法脱敏，使得电刺激的有益效果减弱。 一旦发生脱敏，受影响的组织可能不会有利于电刺激治疗。 应用一种或多种抗脱敏特征来控制胃刺激疗法可以减少或预防脱敏，并有效地延长治疗的疗效。
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9.发明授权公开(公告)号：US07957807B2
公开(公告)日：2011-06-07
申请号：US12236852
申请日：2008-09-24
IPC分类号： A61N1/18
CPC分类号： A61N1/36007
摘要： The disclosure is directed to gastric stimulation programmers, stimulators and methods for controlling delivery of gastric stimulation therapy to maintain the efficacy of the therapy over time. Maintaining the efficacy of gastric stimulation therapy may be possible by implementing one or more anti-desensitization features in a gastric stimulation controller or stimulator. As electrical stimulation therapy is continuously delivered to a patient, the stimulated tissue may become desensitized to the electrical stimulation therapy such that the beneficial effect of the electrical stimulation is diminished. Once desensitization occurs, the affected tissue may not respond favorably to electrical stimulation therapy. Application of one or more anti-desensitization features to control gastric stimulation therapy may reduce or prevent desensitization and effectively extend the efficacy of the therapy over time.
摘要翻译： 本公开涉及胃刺激程序员，刺激剂和用于控制胃刺激治疗递送的方法，以保持治疗随时间的功效。 通过在胃刺激控制器或刺激器中实施一种或多种抗脱敏特征，可以维持胃刺激治疗的功效。 随着电刺激治疗被持续递送到患者，刺激的组织可能变得对电刺激疗法脱敏，使得电刺激的有益效果减弱。 一旦发生脱敏，受影响的组织可能不会有利于电刺激治疗。 应用一种或多种抗脱敏特征来控制胃刺激疗法可以减少或预防脱敏，并有效地延长治疗的疗效。
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公开(公告)号：US20110071589A1
公开(公告)日：2011-03-24
申请号：US12887149
申请日：2010-09-21
申请人： Warren L. Starkebaum , Roland C. Maude-Griffin , Elizabeth D. Firestone , Carl A. Schu , Orhan Soykan
发明人： Warren L. Starkebaum , Roland C. Maude-Griffin , Elizabeth D. Firestone , Carl A. Schu , Orhan Soykan
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61N1/36085 , A61N1/36171 , A61N1/36175
摘要： In some examples, the disclosure relates to a systems, devices, and techniques for delivering electrical stimulation therapy to a patient. In one example, the disclosure relates to a method including delivering a series of pulses with alternating pulse polarities to a gastrointestinal tract of a patient. The series of pulses includes at least a first pulse of a first polarity, a second pulse of a second polarity, and a third pulse of the first polarity, where the first, second and third pulses are delivered in direct succession and in that order. The first and second pulses are separated by a first time delay and the second and third pulses are separated by a second time delay. In some examples, each of the first and second time delays depend on the frequency that the series of pulses are delivered.
摘要翻译： 在一些示例中，本公开涉及用于向患者递送电刺激治疗的系统，装置和技术。 在一个示例中，本公开涉及包括将具有交替脉冲极性的一系列脉冲递送到患者的胃肠道的方法。 一系列脉冲包括至少第一极性的第一脉冲，第二极性的第二脉冲和第一极性的第三脉冲，其中第一，第二和第三脉冲以直接连续的顺序递送。 第一和第二脉冲被第一时间延迟分开，第二和第三脉冲被第二时间延迟分开。 在一些示例中，第一和第二时间延迟中的每一个取决于一系列脉冲被传送的频率。
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