公开(公告)号：US09528968B2

公开(公告)日：2016-12-27

申请号：US14881395

申请日：2015-10-13

Applicant: Waters Technologies Corporation

Inventor： James P. Murphy ,  Angela Doneanu

IPC: H01J49/10 ,  G01N30/72 ,  G01N30/32 ,  G01N30/06

CPC classification number: G01N30/7266 ,  B01L3/5027 ,  G01N30/06 ,  G01N30/32 ,  G01N30/34 ,  G01N30/6095 ,  G01N30/84 ,  G01N2030/326 ,  H01J49/167

Abstract: A microfluidic liquid chromatography-electrospray ionization (LC-ESI) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent. The mixed flow stream thus obtained is used for generating an electrospray containing analyte ions. Also provided are methods for enhanced sensitivity of detection of an analyte in a sample.

Abstract translation: 提供微流体液相色谱 - 电喷雾离子化（LC-ESI）装置，用于提高样品中分析物质谱检测的灵敏度。 该设备旨在驱动离开色谱固定相和柱后改性剂的分析流的有效混合。 由此获得的混合流动流用于产生含有分析物离子的电喷雾。 还提供了增强样品中分析物检测灵敏度的方法。

公开(公告)号：US20160131620A1

公开(公告)日：2016-05-12

申请号：US14881395

申请日：2015-10-13

Applicant: Waters Technologies Corporation

Inventor： James P. Murphy ,  Angela Doneanu

IPC: G01N30/72 ,  G01N30/06 ,  G01N30/32

CPC classification number: G01N30/7266 ,  B01L3/5027 ,  G01N30/06 ,  G01N30/32 ,  G01N30/34 ,  G01N30/6095 ,  G01N30/84 ,  G01N2030/326 ,  H01J49/167

Abstract: A microfluidic liquid chromatography-electrospray ionization (LC-ESI) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent. The mixed flow stream thus obtained is used for generating an electrospray containing analyte ions. Also provided are methods for enhanced sensitivity of detection of an analyte in a sample.

Abstract translation: 提供微流体液相色谱 - 电喷雾离子化（LC-ESI）装置，用于提高样品中分析物质谱检测的灵敏度。 该设备旨在驱动离开色谱固定相和柱后改性剂的分析流的有效混合。 由此获得的混合流动流用于产生含有分析物离子的电喷雾。 还提供了增强样品中分析物检测灵敏度的方法。