公开(公告)号：US20240393299A1

公开(公告)日：2024-11-28

申请号：US18669944

申请日：2024-05-21

Applicant: Waters Technologies Corporation

Inventor： Michael Scanlon ,  Joseph D. Michienzi ,  Wade P. Leveille

IPC: G01N30/60 ,  B01D15/22

Abstract: A device for sealing to a chromatographic column includes an insertion body and a tip assembly. The insertion body has an attachment end, a tip opposite to the attachment end and a fluidic channel extending between the attachment end and the tip. An attachment feature located near the attachment end secures the insertion body to an actuator. An axially movable sheath may be provided at the tip to protect the tip assembly prior to and during coupling to a column end nut and to assist in aligning the device to the column end nut. The device can be loaded by manual clamping or by an automated clamp mechanism to achieve sufficient force for a fluid tight seal in the column end nut. Devices are column agnostic and may be used in a column oven to enable a chromatography system to be quickly configured with a wide variety of columns.

公开(公告)号：US20240302335A1

公开(公告)日：2024-09-12

申请号：US18598803

申请日：2024-03-07

Applicant: Waters Technologies Corporation

Inventor： Michael Scanlon ,  Wade P. Leveille ,  Joseph D. Michienzi

IPC: G01N30/60 ,  B01D15/10 ,  F16L19/00 ,  G01N30/02

CPC classification number: G01N30/6026 ,  B01D15/10 ,  F16L19/00 ,  G01N2030/027

Abstract: Threaded conventional column end fittings for liquid chromatography columns do not have face seals that enable them to be used with clamping fluidic connectors. The exemplary embodiments may provide adapters that interface with conventional threaded column end fittings so that the column assembly may now be used with the clamping fluidic connectors. The adapters of the exemplary embodiments may include lock nuts for securing the adapters to column end fittings of a liquid chromatography columns. The lock nuts may include threads that bear the load of the adapter rather than the column end fitting of the chromatography column. The threads of the lock nut become the load bearing surfaces, and the load is distributed over the surfaces where the threads of the adapter engage with the threads of the lock nut.