-
公开(公告)号：US20210220814A1
公开(公告)日：2021-07-22
申请号：US17221471
申请日：2021-04-02
IPC分类号： B01J43/00 , B01J20/28 , B01J20/285 , B01J39/20 , B01J41/14 , B01J20/26 , B01D15/08 , C08F226/06
摘要： The present invention provides porous materials for use in solid phase extractions and chromatography. In particular, the materials exhibit superior properties in the SPE analysis of biological materials. In certain aspects, the porous materials comprise a copolymer of a least one hydrophobic monomer and at least one hydrophilic monomer, wherein more than 10% of the BJH surface area of the porous material is contributed by pores that have a diameter greater than or equal to 200 Å, wherein said material has a median pore diameter of about 100 Å to about 1000 Å, or both. In some embodiments, the at least one hydrophilic monomer has a log P value of less than 0.5. In some embodiments, the at least one hydrophilic monomer is selected from 4-acryloymorphine, N-(3-methoxypropyl)acrylamide, N,N′-methylenebis(acrylamide), acrylonitrile, ethylene glycol dimethacrylate, methyl acrylate, 4-acetoxystyrene, 4-vinyl pyridine, or a boronic-acid-containing monomer, among others.
-
公开(公告)号：US20230126856A1
公开(公告)日：2023-04-27
申请号：US17970962
申请日：2022-10-21
发明人： Matthew A. Lauber , Darryl W. Brousmiche , Jun Yang , Weiqiang Gu , Mingcheng Xu , Peng Chen
IPC分类号： G01N33/68 , C07D207/46
摘要： Provided herein chiral derivatization reagents for use in separating and detecting of amine containing enantiomers. The said chiral derivatization reagents provide a combination of improved detectable properties to facilitate various downstream analyses. In particular, the chiral derivatization reagents include at least one chiral carbon atom; at least one strongly basic moiety; at least one chromophore moiety or at least one fluorophore moiety; and at least one reactive group. The present disclosure further provides methods for analyzing amine-containing enantiomeric isomers using a chromatographic separation device and a mass spectroscopy.
-
公开(公告)号：US20210387177A1
公开(公告)日：2021-12-16
申请号：US17314782
申请日：2021-05-07
摘要： The present disclosure relates to a system for separating a sample including a device and a positive pressure source. The device can include a housing with a proximal end having an interface and a proximal end opening, a distal end opening opposite the proximal end opening, and an interior wall defining an interior of the housing; a bottom frit connected to the interior wall, extending across the interior of the housing, and located proximately to the distal end to minimize sample loss; and a resin disposed within the interior of the housing between the bottom frit and the proximal end. The positive pressure source can connect to the interface of the proximal end to apply positive pressure to the sample. A controller can control the applied positive pressure to the sample via the positive pressure source according to a relationship between the bottom frit, the resin, and the positive pressure.
-
公开(公告)号：US20190322783A1
公开(公告)日：2019-10-24
申请号：US16287364
申请日：2019-02-27
IPC分类号： C08F220/18 , C08K5/00 , C08K5/14 , C08K5/23 , C08F2/06 , C08F220/28 , C08F220/56 , C08F212/08 , C08L39/06
摘要： The current invention provides a novel method to synthesize a mono-disperse non-porous polymer particles with a unique gradient composition from the core to the shell. In particular, The present invention offers the flexibility to design the chemical and physical properties of different sections of the particle. This flexibility allows for significant latitude in the design of particles for analyzing a large variety of samples in different fields—through using these particles in different chromatography techniques including, but not limited to, ion exchange HPLC (e.g., bio-separation at different modes), reversed-phase HPLC, narrow bore and capillary HPLC, hydrophilic/hydrophobic interaction liquid chromatography, capillary electrochromatography separation, and two dimensional liquid chromatography.
-
-
-
搜索结果
4 条记录 (耗时 0.012 秒)
