公开(公告)号：US20190322783A1

公开(公告)日：2019-10-24

申请号：US16287364

申请日：2019-02-27

Applicant: Waters Technologies Corporation

Inventor： Darryl W. Brousmiche ,  Kevin Daniel Wyndham ,  Mingcheng Xu ,  Michael F. Morris

IPC: C08F220/18 ,  C08K5/00 ,  C08K5/14 ,  C08K5/23 ,  C08F2/06 ,  C08F220/28 ,  C08F220/56 ,  C08F212/08 ,  C08L39/06

Abstract: The current invention provides a novel method to synthesize a mono-disperse non-porous polymer particles with a unique gradient composition from the core to the shell. In particular, The present invention offers the flexibility to design the chemical and physical properties of different sections of the particle. This flexibility allows for significant latitude in the design of particles for analyzing a large variety of samples in different fields—through using these particles in different chromatography techniques including, but not limited to, ion exchange HPLC (e.g., bio-separation at different modes), reversed-phase HPLC, narrow bore and capillary HPLC, hydrophilic/hydrophobic interaction liquid chromatography, capillary electrochromatography separation, and two dimensional liquid chromatography.

公开(公告)号：US10092894B2

公开(公告)日：2018-10-09

申请号：US14194686

申请日：2014-03-01

Applicant: Waters Technologies Corporation

Inventor： Darryl W. Brousmiche ,  Jacob N. Fairchild ,  Jason F. Hill ,  Giorgis Isaac ,  Michael F. Morris ,  Kevin D. Wyndham

IPC: B01J20/283 ,  B01J20/284 ,  B01J20/285 ,  B01J20/282 ,  B01J20/28 ,  C07F7/18 ,  B01D15/26 ,  B01J20/288 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01D53/02 ,  B01J20/22 ,  B01J20/289 ,  B01J20/30 ,  B01J20/32

Abstract: The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group.

公开(公告)号：US20240293799A1

公开(公告)日：2024-09-05

申请号：US18644518

申请日：2024-04-24

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Michael F. Morris ,  Darryl W. Brousmiche ,  Jason F. Hill ,  Jacob N. Fairchild

IPC: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01D53/02 ,  B01J20/22 ,  B01J20/28 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/30 ,  B01J20/32 ,  C07F7/18

CPC classification number: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  C07F7/1804 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/32 ,  B01J20/3234 ,  B01J2220/54 ,  B01J2220/80

Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

公开(公告)号：US11747310B2

公开(公告)日：2023-09-05

申请号：US16664403

申请日：2019-10-25

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Michael F. Morris ,  Matthew A. Lauber ,  Darryl W. Brousmiche

IPC: G01N30/00 ,  G01N30/02 ,  B01D15/30 ,  C07D215/48 ,  G01N30/04 ,  C07H15/26 ,  G01N30/88 ,  G01N33/68 ,  G01N30/62

CPC classification number: G01N30/02 ,  B01D15/305 ,  C07D215/48 ,  C07H15/26 ,  G01N30/04 ,  G01N30/88 ,  G01N33/6842 ,  G01N2030/027 ,  G01N2030/047 ,  G01N2030/626 ,  G01N2030/8836 ,  G01N2400/00 ,  G01N2440/38

Abstract: Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography. The methodologies include a two-step process comprising a reductive amination step of providing a reducing glycan and reacting it with a compound having a primary amine to produce an intermediate compound. The intermediate compound is then rapidly tagged with a rapid tagging reagent to produce the rapid labeled dextran ladder.

公开(公告)号：US10744484B2

公开(公告)日：2020-08-18

申请号：US16058069

申请日：2018-08-08

Applicant: Waters Technologies Corporation

Inventor： Darryl W. Brousmiche ,  Jacob N. Fairchild ,  Jason F. Hill ,  Giorgis Isaac ,  Michael F. Morris ,  Kevin D. Wyndham

IPC: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/40 ,  B01J20/22 ,  B01J20/32 ,  C07F7/18 ,  B01J20/288 ,  B01J20/28 ,  B01D15/32 ,  B01D53/02 ,  B01J20/289 ,  B01J20/30 ,  B01J20/285 ,  B01J20/284 ,  B01J20/282

Abstract: The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group. In some examples, the present disclosure can include a chromatographic system having a chromatographic column having a stationary phase with a chromatographic substrate containing silica, metal oxide, an inorganic-organic hybrid material, a group of block copolymers, or a combination thereof.

公开(公告)号：US11999808B2

公开(公告)日：2024-06-04

申请号：US16287364

申请日：2019-02-27

Applicant: Waters Technologies Corporation

Inventor： Darryl W. Brousmiche ,  Kevin Daniel Wyndham ,  Mingcheng Xu ,  Michael F. Morris

IPC: C08F285/00 ,  C08F2/04 ,  C08F2/06 ,  C08F212/08 ,  C08F220/56 ,  C08K5/00 ,  C08K5/14 ,  C08K5/23 ,  C08L39/06 ,  C08F220/28

CPC classification number: C08F2/04 ,  C08F2/06 ,  C08F212/08 ,  C08F220/56 ,  C08K5/005 ,  C08K5/14 ,  C08K5/23 ,  C08L39/06 ,  C08F220/281 ,  C08L2205/24 ,  C08L2207/53 ,  C08F285/00 ,  C08F220/325

Abstract: The current invention provides a novel method to synthesize a mono-disperse non-porous polymer particles with a unique gradient composition from the core to the shell. In particular, The present invention offers the flexibility to design the chemical and physical properties of different sections of the particle. This flexibility allows for significant latitude in the design of particles for analyzing a large variety of samples in different fields—through using these particles in different chromatography techniques including, but not limited to, ion exchange HPLC (e.g., bio-separation at different modes), reversed-phase HPLC, narrow bore and capillary HPLC, hydrophilic/hydrophobic interaction liquid chromatography, capillary electrochromatography separation, and two dimensional liquid chromatography.

公开(公告)号：US11992824B2

公开(公告)日：2024-05-28

申请号：US17353096

申请日：2021-06-21

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Michael F. Morris ,  Darryl W. Brousmiche ,  Jason F. Hill ,  Jacob N. Fairchild

IPC: B01J20/28 ,  B01D15/26 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01D53/02 ,  B01J20/22 ,  B01J20/283 ,  B01J20/288 ,  B01J20/289 ,  B01J20/30 ,  B01J20/32 ,  C07F7/18 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285

CPC classification number: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  C07F7/1804 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/32 ,  B01J20/3234 ,  B01J2220/54 ,  B01J2220/80

Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

公开(公告)号：US20190217273A1

公开(公告)日：2019-07-18

申请号：US16359328

申请日：2019-03-20

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Michael F. Morris ,  Darryl W. Brousmiche ,  Jason F. Hill ,  Jacob N. Fairchild

IPC: B01J20/283 ,  C07F7/18 ,  B01J20/28 ,  B01D15/26 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01J20/288 ,  B01J20/32 ,  B01J20/289 ,  B01D53/02 ,  B01J20/22 ,  B01J20/30

CPC classification number: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3234 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/80 ,  C07F7/1804

Abstract: In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

公开(公告)号：US12083498B2

公开(公告)日：2024-09-10

申请号：US16926102

申请日：2020-07-10

Applicant: Waters Technologies Corporation

Inventor： Darryl W. Brousmiche ,  Jacob N. Fairchild ,  Jason F. Hill ,  Giorgis Isaac ,  Michael F. Morris ,  Kevin D. Wyndham

IPC: B01D15/26 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01D53/02 ,  B01J20/22 ,  B01J20/28 ,  B01J20/282 ,  B01J20/283 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/30 ,  B01J20/32 ,  C07F7/18

CPC classification number: B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  C07F7/1804 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/32 ,  B01J20/3234 ,  B01J2220/54 ,  B01J2220/80

Abstract: The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group. In some examples, the present disclosure can include a chromatographic system having a chromatographic column having a stationary phase with a chromatographic substrate containing silica, metal oxide, an inorganic-organic hybrid material, a group of block copolymers, or a combination thereof.

公开(公告)号：US20210237033A1

公开(公告)日：2021-08-05

申请号：US17221376

申请日：2021-04-02

Applicant: Waters Technologies Corporation

Inventor： Kevin D. Wyndham ,  Beatrice W. Muriithi ,  Michael F. Morris ,  Nicole L. Lawrence

IPC: B01J20/283 ,  B01J20/32 ,  B01J20/285

Abstract: Novel chromatographic materials for chromatographic separations, columns, kits, and methods for preparation and separations with a superficially porous material comprising a substantially nonporous core and one or more layers of a porous shell material surrounding the core. The material of the invention is comprised of superficially porous particles and a narrow particle size distrution. The material of the invention is comprised of a superficially porous monolith, the substantially nonporous core material is silica; silica coated with an inorganic/organic hybrid surrounding materia; a magnetic core material; a magnetic core material coated with silica; a high thermal conductivity core material; a high thermal conductivity core material coated with silica; a composite material; an inorganic/organic hybrid surrounding material; a composite material coated with silica; a magnetic core material coated with an inorganic/organic hybrid surrounding material; or a high thermal conductivity core material coated with an inorganic/organic hybrid surrounding material.