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    NUCLEIC ACIDS ENCODING A HOUSE DUST MITE ALLERGEN, DER P III, AND USES THEREFOR
    1.
    发明申请
    NUCLEIC ACIDS ENCODING A HOUSE DUST MITE ALLERGEN, DER P III, AND USES THEREFOR 有权
    核酸编码一个房屋尘埃冥王星过敏原，第三阶段及其用途

    公开(公告)号：US20110117116A1

    公开(公告)日：2011-05-19

    申请号：US12688744

    申请日：2010-01-15

    申请人： Wayne R. THOMAS ,  Kaw-Yan Chua ,  Bruce L. Rogers ,  Mei-chang Kuo

    发明人： Wayne R. THOMAS ,  Kaw-Yan Chua ,  Bruce L. Rogers ,  Mei-chang Kuo

    IPC分类号： A61K39/35 ,  C12P21/02 ,  G01N33/566 ,  A61P37/08 ,  A61P37/04

    CPC分类号： C07K14/43531 ,  A61K38/00

    摘要： Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

    摘要翻译： 公开了编码Dermatophagoides pteronyssinus，Der p III的变应原的分离的核酸。 还描述了编码具有Der p III活性和约24,985道尔顿的预测分子量的肽的cDNA。 核酸可以用作探针，以检测样品中Der p III核酸的存在或重组产生具有Der p III活性的肽。 具有Der p III活性的肽可用于适用于药物施用的组合物或诊断对尘螨敏感性的方法。

    Cloning and sequencing of allergens of dermatophagoides (house dust mite)
    2.
    发明授权
    Cloning and sequencing of allergens of dermatophagoides (house dust mite) 失效
    皮肤癣菌过敏原（室内尘螨）的克隆和测序

    公开(公告)号：US5773002A

    公开(公告)日：1998-06-30

    申请号：US461441

    申请日：1995-06-05

    申请人： Wayne R. Thomas ,  Kaw-Yan Chua

    发明人： Wayne R. Thomas ,  Kaw-Yan Chua

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/35 ,  A61K39/36 ,  A61K39/395 ,  A61P37/08 ,  C07H21/04 ,  C07K14/435 ,  C07K14/54 ,  C12N15/12 ,  C12P21/02 ,  C12R1/19

    CPC分类号： C07K14/43531 ,  C07K14/5403 ,  A61K38/00 ,  Y10S436/826

    摘要： The present invention features isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, the invention provides DNA encoding the major D. farinae allergens, Der f I and Der f II and DNA encoding the major D. pteronvssinus allergens, Der p I and Der p II. The present invention further relates to proteins and peptides encoded by the isolated D. farinae and D. pteronvssinus DNA, including proteins containing sequence polymorphisms. In addition, the proteins or peptides encoded by the isolated DNA, their use a diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens, are disclosed.

    摘要翻译： 本发明的特征在于编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是包括蛋白质变应原的至少一个表位的蛋白质过敏原或肽。 特别地，本发明提供编码主要D. farinae变应原Der f I和Der f II的DNA和编码主要D.pteronvssinus变应原Der P I和Der p II的DNA。 本发明还涉及由分离的D. farinae和D.pteronvssinus DNA编码的蛋白质和肽，包括含有序列多态性的蛋白质。 此外，公开了由分离的DNA编码的蛋白质或肽，它们使用诊断和治疗试剂以及诊断和治疗对尘螨过敏原敏感性的方法。

    Nucleic acids encoding a house dust mite allergen Der p III, and uses therefor
    3.
    发明授权
    Nucleic acids encoding a house dust mite allergen Der p III, and uses therefor 失效
    编码房屋尘螨过敏原Der p III的核酸，并用于此

    公开(公告)号：US06752991B1

    公开(公告)日：2004-06-22

    申请号：US08462515

    申请日：1995-06-05

    申请人： Wayne R. Thomas ,  Kaw-Yan Chua ,  Bruce L. Rogers ,  Mei-chang Kuo

    发明人： Wayne R. Thomas ,  Kaw-Yan Chua ,  Bruce L. Rogers ,  Mei-chang Kuo

    IPC分类号： A61K3564

    CPC分类号： C07K14/43531 ,  A61K38/00

    摘要： Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

    摘要翻译： 公开了编码Dermatophagoides pteronyssinus，Der p III的变应原的分离的核酸。 还描述了编码具有Der p III活性和约24,985道尔顿的预测分子量的肽的cDNA。 核酸可以用作探针，以检测样品中Der p III核酸的存在或重组产生具有Der p III活性的肽。 具有Der p III活性的肽可用于适用于药物施用的组合物或诊断对尘螨敏感性的方法。

    NUCLEIC ACIDS ENCODING A HOUSE DUST MITE ALLERGEN, DER P III, AND USES THEREOF
    6.
    发明申请
    NUCLEIC ACIDS ENCODING A HOUSE DUST MITE ALLERGEN, DER P III, AND USES THEREOF 审中-公开
    核酸编码一个房屋尘土蛭石过敏原，第三阶段及其用途

    公开(公告)号：US20110059522A1

    公开(公告)日：2011-03-10

    申请号：US12358954

    申请日：2009-01-23

    申请人： Wayne R. THOMAS ,  Kaw-Yan Chua ,  Bruce L. Rogers ,  Mei-chang Kuo

    发明人： Wayne R. THOMAS ,  Kaw-Yan Chua ,  Bruce L. Rogers ,  Mei-chang Kuo

    IPC分类号： C12N5/0783 ,  C07K16/18

    CPC分类号： C07K14/43531 ,  A61K38/00

    摘要： Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

    摘要翻译： 公开了编码Dermatophagoides pteronyssinus，Der p III的变应原的分离的核酸。 还描述了编码具有Der p III活性和约24,985道尔顿的预测分子量的肽的cDNA。 核酸可以用作探针，以检测样品中Der p III核酸的存在或重组产生具有Der p III活性的肽。 具有Der p III活性的肽可用于适用于药物施用的组合物或诊断对尘螨敏感性的方法。

    Cloning and sequencing of allergens of dermatophagoides (house dust mite)
    7.
    发明授权
    Cloning and sequencing of allergens of dermatophagoides (house dust mite) 失效
    皮肤癣菌过敏原（室内尘螨）的克隆和测序

    公开(公告)号：US5552142A

    公开(公告)日：1996-09-03

    申请号：US462831

    申请日：1995-06-05

    申请人： Wayne R. Thomas ,  Kaw-Yan Chua

    发明人： Wayne R. Thomas ,  Kaw-Yan Chua

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/35 ,  A61K39/36 ,  A61K39/395 ,  A61P37/08 ,  C07H21/04 ,  C07K14/435 ,  C07K14/54 ,  C12N15/12 ,  C12P21/02 ,  C12R1/19 ,  A61K39/00

    CPC分类号： C07K14/43531 ,  C07K14/5403 ,  A61K38/00 ,  Y10S436/826

    摘要： The present invention features isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, the invention provides DNA encoding the major D, farinae allergens, Der f I and Der f II and DNA encoding the major D. pteronyssinus allergens, Der p I and Der p II. The present invention further relates to proteins and peptides encoded by the isolated D. farinae and D. pteronyssinus DNA, including proteins containing sequence polymorphisms. In addition, the proteins or peptides encoded by the isolated DNA, their use a diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens, are disclosed.

    摘要翻译： 本发明的特征在于编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是包括蛋白质变应原的至少一个表位的蛋白质过敏原或肽。 特别地，本发明提供编码主要D，farinae变应原Der f I和Der f II的DNA和编码主要D.pteronyssinus变应原Der P I和Der p II的DNA。 本发明还涉及由分离的D. farinae和D.pteronyssinus DNA编码的蛋白质和肽，包括含有序列多态性的蛋白质。 此外，公开了由分离的DNA编码的蛋白质或肽，它们使用诊断和治疗试剂以及诊断和治疗对尘螨过敏原敏感性的方法。

    Cloning and sequencing of allergens of dermatophagoides (house dust mite)
    8.
    发明授权
    Cloning and sequencing of allergens of dermatophagoides (house dust mite) 失效
    皮肤癣菌过敏原（室内尘螨）的克隆和测序

    公开(公告)号：US5433948A

    公开(公告)日：1995-07-18

    申请号：US945288

    申请日：1992-09-10

    申请人： Wayne R. Thomas ,  Kaw-Yan Chua

    发明人： Wayne R. Thomas ,  Kaw-Yan Chua

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/35 ,  A61K39/36 ,  A61K39/395 ,  A61P37/08 ,  C07H21/04 ,  C07K14/435 ,  C07K14/54 ,  C12N15/12 ,  C12P21/02 ,  C12R1/19 ,  C07K19/00

    CPC分类号： C07K14/43531 ,  C07K14/5403 ,  A61K38/00 ,  Y10S436/826

    摘要： The present invention features isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, the invention provides DNA encoding the major D. farinae allergens, Der f I and Der f II and DNA encoding the major D. pteronyssinus allergens, Der p I and Der p II. The present invention further relates to proteins and peptides encoded by the isolated D. farinae and D. pteronyssinus DNA, including proteins containing sequence polymorphisms. In addition, the proteins or peptides encoded by the isolated DNA, their use a diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens, are disclosed.

    摘要翻译： 本发明的特征在于编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是包括蛋白质变应原的至少一个表位的蛋白质过敏原或肽。 特别地，本发明提供编码主要D. farinae过敏原Der f I和Der f II的DNA和编码主要D.pteronyssinus变应原Der P I和Der p II的DNA。 本发明还涉及由分离的D. farinae和D.pteronyssinus DNA编码的蛋白质和肽，包括含有序列多态性的蛋白质。 此外，公开了由分离的DNA编码的蛋白质或肽，它们使用诊断和治疗试剂以及诊断和治疗对尘螨过敏原敏感性的方法。

    Nucleic acids encoding a house dust mite allergen, Der p III, and uses thereof
    9.
    发明授权
    Nucleic acids encoding a house dust mite allergen, Der p III, and uses thereof 有权
    编码房尘螨过敏原的核酸，Der p III及其用途

    公开(公告)号：US09447154B2

    公开(公告)日：2016-09-20

    申请号：US12358954

    申请日：2009-01-23

    申请人： Wayne R. Thomas ,  Kaw-Yan Chua ,  Bruce L. Rogers ,  Mei-chang Kuo

    发明人： Wayne R. Thomas ,  Kaw-Yan Chua ,  Bruce L. Rogers ,  Mei-chang Kuo

    IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C12P21/08 ,  C07K14/435 ,  A61K38/00

    CPC分类号： C07K14/43531 ,  A61K38/00

    摘要： Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.

    摘要翻译： 公开了编码Dermatophagoides pteronyssinus，Der p III的变应原的分离的核酸。 还描述了编码具有Der p III活性和约24,985道尔顿的预测分子量的肽的cDNA。 核酸可以用作探针，以检测样品中Der p III核酸的存在或重组产生具有Der p III活性的肽。 具有Der p III活性的肽可用于适用于药物施用的组合物或诊断对尘螨敏感性的方法。

    Nucleic acid molecules encoding a house dust mite allergen Der f VII, and antigenic peptides thereof
    10.
    发明授权
    Nucleic acid molecules encoding a house dust mite allergen Der f VII, and antigenic peptides thereof 失效
    编码房尘螨变应原Der f VII的核酸分子及其抗原肽

    公开(公告)号：US08003382B2

    公开(公告)日：2011-08-23

    申请号：US11084057

    申请日：2005-03-17

    申请人： Wayne R. Thomas ,  Kaw-Yan Chua

    发明人： Wayne R. Thomas ,  Kaw-Yan Chua

    IPC分类号： C07H21/02 ,  C12N15/00

    CPC分类号： C07K14/43531 ,  A61K38/00 ,  C07K14/7051 ,  C07K2319/00 ,  G01N33/56966 ,  G01N33/6893 ,  G01N2800/24 ,  Y10S530/868

    摘要： Isolated nucleic acids encoding allergens of the species Dermatophagoides pteronyssinus and Dermatophagoides farinae, Der p VII and Der f VII, respectively, are disclosed. A cDNA encoding a peptide having a Der p VII activity and a predicted molecular weight of about 22, 177 daltons is described. A cDNA encoding a peptide having Der f VII activity is also described. The nucleic acids of the invention can be used as probes to detect the presence of Der p VII or Der f VII nucleic acid in a sample or for the recombinant production of peptides having a Der p VII or Der f VII activity. Peptides having a Der p VII or Der f VII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mite allergens.

    摘要翻译： 公开了分别编码Dermatophagoides pteronyssinus和Dermatophagoides farinae，Der p VII和Der f VII的变应原的分离的核酸。 描述了编码具有Der p VII活性和约22,171道尔顿的预测分子量的肽的cDNA。 还描述了编码具有Der f VII活性的肽的cDNA。 本发明的核酸可用作探针以检测样品中Der VII或Derf VII核酸的存在，或用于重组产生具有Der p VII或Der f VII活性的肽。 具有Der p VII或Der f VII活性的肽可用于适于药物施用的组合物或诊断对尘螨过敏原敏感性的方法。