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公开(公告)号：US20120329719A1
公开(公告)日：2012-12-27
申请号：US13484162
申请日：2012-05-30
申请人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
发明人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
摘要： A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 μg/ml to about 100 μg/ml for a time sufficient to heal the wound is disclosed.
摘要翻译： 一种伤口愈合组合物，其包含一类多肽化合物，所述多肽化合物具有每链5至120个氨基酸单元的多肽链。 组合物包括携带多肽化合物的药物介质，例如水溶液，悬浮液，分散体，药膏，软膏，凝胶，霜剂，洗剂，喷雾剂或糊剂。 另外，一种施用伤口愈合组合物的方法，其包含一类具有多肽链的多肽化合物，所述多肽化合物具有约1μg/ ml至约100μg/ ml浓度的每链5至120个氨基酸单元，时间足以 治愈伤口披露。
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公开(公告)号：US08410055B2
公开(公告)日：2013-04-02
申请号：US13210200
申请日：2011-08-15
申请人： Wei Li , Mei Chen , David T. Woodley
发明人： Wei Li , Mei Chen , David T. Woodley
CPC分类号： A61K9/0014 , A61K38/1709 , A61L26/0066 , A61L2300/252 , A61L2300/412
摘要： A wound healing composition comprising an amount of heat shock protein effective to promote wound healing and a method thereof to apply the composition. A preferred heat shock protein is either full-length hsp90α or the middle domain plus the charged sequence of hsp90α. The composition is topically applied to skin wounds, covering the outer surface of the wound. The heat shock protein acts by promoting migration of both human epidermal keratinocyte and dermal fibroblasts to the wound in order to close, heal, and remodel the wound.
摘要翻译： 一种伤口愈合组合物，其包含一定量的有效促进伤口愈合的热休克蛋白及其施用该组合物的方法。 优选的热休克蛋白是全长hsp90α或中间结构域加上hsp90α的带电序列。 组合物局部施用于皮肤伤口，覆盖伤口的外表面。 热休克蛋白通过促进人类表皮角质形成细胞和真皮成纤维细胞迁移到伤口来起作用，以关闭，愈合和改造伤口。
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公开(公告)号：US08022037B2
公开(公告)日：2011-09-20
申请号：US12522446
申请日：2008-01-08
申请人： Wei Li , Mei Chen , David T. Woodley
发明人： Wei Li , Mei Chen , David T. Woodley
CPC分类号： A61K9/0014 , A61K38/1709 , A61L26/0066 , A61L2300/252 , A61L2300/412
摘要： A wound healing composition comprising an amount of heat shock protein effective to promote wound healing and a method thereof to apply the composition. A preferred heat shock protein is either full-length hsp90α or the middle domain plus the charged sequence of hsp90α. The composition is topically applied to skin wounds, covering the outer surface of the wound. The heat shock protein acts by promoting migration of both human epidermal keratinocyte and dermal fibroblasts to the wound in order to close, heal, and remodel the wound.
摘要翻译： 一种伤口愈合组合物，其包含一定量的有效促进伤口愈合的热休克蛋白及其施用该组合物的方法。 优选的热休克蛋白是全长hsp90α或中间结构域加上hsp90α的带电序列。 组合物局部施用于皮肤伤口，覆盖伤口的外表面。 热休克蛋白通过促进人类表皮角质形成细胞和真皮成纤维细胞迁移到伤口来起作用，以关闭，愈合和改造伤口。
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公开(公告)号：US20110082082A1
公开(公告)日：2011-04-07
申请号：US12505361
申请日：2009-07-17
申请人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
发明人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
摘要： A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 pg/ml to about 100 μg/ml for a time sufficient to heal the wound is disclosed.
摘要翻译： 一种伤口愈合组合物，其包含一类多肽化合物，所述多肽化合物具有每链5至120个氨基酸单元的多肽链。 组合物包括携带多肽化合物的药物介质，例如水溶液，悬浮液，分散体，药膏，软膏，凝胶，霜剂，洗剂，喷雾剂或糊剂。 另外，一种施用伤口愈合组合物的方法，其包含一类多肽化合物，所述多肽化合物具有多肽链，每个链具有约5至120个氨基酸单位，浓度为约1μg/ ml至约100μg/ ml，时间足以 治愈伤口披露。
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公开(公告)号：US08455443B2
公开(公告)日：2013-06-04
申请号：US13484162
申请日：2012-05-30
申请人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
发明人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
摘要： A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 μg/ml to about 100 μg/ml for a time sufficient to heal the wound is disclosed.
摘要翻译： 一种伤口愈合组合物，其包含一类多肽化合物，所述多肽化合物具有每链5至120个氨基酸单元的多肽链。 组合物包括携带多肽化合物的药物介质，例如水溶液，悬浮液，分散体，药膏，软膏，凝胶，霜剂，洗剂，喷雾剂或糊剂。 另外，一种施用伤口愈合组合物的方法，所述伤口愈合组合物包含一类多肽化合物，所述多肽化合物具有多肽链，每个链具有5至120个氨基酸单位，浓度为约1mug / ml至约100mug / ml，持续足够的时间 治愈伤口披露。
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6.发明申请FRAGMENT OF SECRETED HEAT SHOCK PROTEIN-90ALPHA (Hsp90ALPHA) AS VACCINES OR EPITOPE FOR MONOCLONAL ANTIBODY DRUGS OR TARGET FOR SMALL MOLECULE DRUGS AGAINST A RANGE OF SOLID HUMAN TUMORS 审中-公开分散的热休克蛋白-90ALPHA（Hsp90ALPHA）作为疫苗或抗生素用于单克隆抗体药物或靶向小分子药物对抗人类肿瘤范围的片段公开(公告)号：US20120121595A1
公开(公告)日：2012-05-17
申请号：US13271076
申请日：2011-10-11
申请人： Wei Li , David T. Woodley , Mei Chen
发明人： Wei Li , David T. Woodley , Mei Chen
IPC分类号： A61K39/395 , C12N15/12 , C07K16/18 , A61K39/00 , A61K31/7105 , C12Q1/68 , A61P35/00 , A61P35/04 , C12N15/63 , C12N1/21 , C12N5/10 , G01N33/566 , C07K7/08 , A61K31/713
CPC分类号： C07K14/435 , A61K31/713 , A61K39/0005 , C07K14/47 , C07K16/18 , C07K2317/76 , G01N33/57484 , G01N33/92 , G01N2333/70596 , G01N2500/10
摘要： The invention provides methods for treating HIF-1α-overexpressing human tumors, inhibiting HIF-1α-overexpressing tumor invasion and preventing tumor metastasis, and/or promoting tumor prophylaxis, using various types of inhibitors against the Hsp90α from the tumors.
摘要翻译： 本发明提供使用各种类型的针对肿瘤Hsp90α的抑制剂治疗HIF-1α-过表达人类肿瘤，抑制HIF-1α-过表达肿瘤浸润和预防肿瘤转移和/或促进肿瘤预防的方法。
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公开(公告)号：US20100035815A1
公开(公告)日：2010-02-11
申请号：US12522446
申请日：2008-01-08
申请人： Wei Li , Mei Chen , David T. Woodley
发明人： Wei Li , Mei Chen , David T. Woodley
CPC分类号： A61K9/0014 , A61K38/1709 , A61L26/0066 , A61L2300/252 , A61L2300/412
摘要： A wound healing composition comprising an amount of heat shock protein effective to promote wound healing and a method thereof to apply the composition. A preferred heat shock protein is either full-length hsp90α or the middle domain plus the charged sequence of hsp90α. The composition is topically applied to skin wounds, covering the outer surface of the wound. The heat shock protein acts by promoting migration of both human epidermal keratinocyte and dermal fibroblasts to the wound in order to close, heal, and remodel the wound.
摘要翻译： 一种伤口愈合组合物，其包含一定量的有效促进伤口愈合的热休克蛋白及其施用该组合物的方法。 优选的热休克蛋白是全长hsp90α或中间结构域加上hsp90α的带电序列。 组合物局部施用于皮肤伤口，覆盖伤口的外表面。 热休克蛋白通过促进人类表皮角质形成细胞和真皮成纤维细胞迁移到伤口来起作用，以关闭，愈合和改造伤口。
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公开(公告)号：US08207118B2
公开(公告)日：2012-06-26
申请号：US12505361
申请日：2009-07-17
申请人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
发明人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
摘要： A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 μg/ml to about 100 μg/ml for a time sufficient to heal the wound is disclosed.
摘要翻译： 一种伤口愈合组合物，其包含一类多肽化合物，所述多肽化合物具有每链5至120个氨基酸单元的多肽链。 组合物包括携带多肽化合物的药物介质，例如水溶液，悬浮液，分散体，药膏，软膏，凝胶，霜剂，洗剂，喷雾剂或糊剂。 另外，一种施用伤口愈合组合物的方法，其包含一类具有多肽链的多肽化合物，所述多肽化合物具有约1μg/ ml至约100μg/ ml浓度的每链5至120个氨基酸单元，时间足以 治愈伤口披露。
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9.发明授权Number automatic routing method, updating method, withdrawing method, router and device 有权号码自动路由方式，更新方式，撤销方式，路由器和设备公开(公告)号：US08665887B2
公开(公告)日：2014-03-04
申请号：US13059934
申请日：2009-07-29
申请人： Shu Ge , Jinxia Sun , Meng You , Wei Li , Wei Li , Yutian Nie , Yue Li , Lihong Wei , Sitao Lin
发明人： Shu Ge , Jinxia Sun , Meng You , Wei Li , Wei Li , Yutian Nie , Yue Li , Lihong Wei , Sitao Lin
IPC分类号： H04L12/28
CPC分类号： H04L45/04 , H04L45/50 , H04L45/52 , H04L45/741
摘要： A number automatic routing method, an updating method, a withdrawing method, a router and a device is provided wherein the number automatic routing method includes: converting to-be-distributed number into number routing information to add to dynamic routing protocol; generating a dynamic routing protocol message according to the number routing information; transmitting the dynamic routing protocol message through an Internet Protocol (IP) network and distributing the number through the dynamic routing protocol message and the IP network. The method supports automatic routing of numbers such as E.164 and E.214 and SP through expanding current Multi-Protocol Border Gateway Protocol (MP-BGP) that optimizes network structure and improves efficiency.
摘要翻译： 提供了一种数字自动路由方法，更新方法，撤销方法，路由器和设备，其中号码自动路由方法包括：将分配的号码转换为号码路由信息以添加到动态路由协议; 根据号码路由信息生成动态路由协议消息; 通过互联网协议（IP）网络传输动态路由协议消息，并通过动态路由协议消息和IP网络分配号码。 该方法通过扩展当前的优化网络结构并提高效率的多协议边界网关协议（MP-BGP）来支持自动路由数字，如E.164和E.214和SP。
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10.发明申请NUMBER AUTOMATIC ROUTING METHOD, UPDATING METHOD, WITHDRAWING METHOD, ROUTER AND DEVICE 有权数字自动路由方法，更新方法，提取方法，路由器和设备公开(公告)号：US20110286466A1
公开(公告)日：2011-11-24
申请号：US13059934
申请日：2009-07-29
申请人： Shu Ge , Jinxia Sun , Meng You , Wei Li , Wei Li , Yutian Nie , Yue Li , Lihong Wei , Sitao Lin
发明人： Shu Ge , Jinxia Sun , Meng You , Wei Li , Wei Li , Yutian Nie , Yue Li , Lihong Wei , Sitao Lin
IPC分类号： H04L12/56
CPC分类号： H04L45/04 , H04L45/50 , H04L45/52 , H04L45/741
摘要： A number automatic routing method, an updating method, a withdrawing method, a router and a device is provided wherein the number automatic routing method includes: converting to-be-distributed number into number routing information to add to dynamic routing protocol; generating a dynamic routing protocol message according to the number routing information; transmitting the dynamic routing protocol message through an Internet Protocol (IP) network and distributing the number through the dynamic routing protocol message and the IP network. The method supports automatic routing of numbers such as E.164 and E.214 and SP through expanding current Multi-Protocol Border Gateway Protocol (MP-BGP) that optimizes network structure and improves efficiency.
摘要翻译： 提供了一种数字自动路由方法，更新方法，撤销方法，路由器和设备，其中号码自动路由方法包括：将分配的号码转换为号码路由信息以添加到动态路由协议; 根据号码路由信息生成动态路由协议消息; 通过互联网协议（IP）网络传输动态路由协议消息，并通过动态路由协议消息和IP网络分配号码。 该方法通过扩展当前的优化网络结构并提高效率的多协议边界网关协议（MP-BGP）来支持自动路由数字，如E.164和E.214和SP。
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