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公开(公告)号：US20120329719A1
公开(公告)日：2012-12-27
申请号：US13484162
申请日：2012-05-30
申请人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
发明人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
摘要： A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 μg/ml to about 100 μg/ml for a time sufficient to heal the wound is disclosed.
摘要翻译： 一种伤口愈合组合物，其包含一类多肽化合物，所述多肽化合物具有每链5至120个氨基酸单元的多肽链。 组合物包括携带多肽化合物的药物介质，例如水溶液，悬浮液，分散体，药膏，软膏，凝胶，霜剂，洗剂，喷雾剂或糊剂。 另外，一种施用伤口愈合组合物的方法，其包含一类具有多肽链的多肽化合物，所述多肽化合物具有约1μg/ ml至约100μg/ ml浓度的每链5至120个氨基酸单元，时间足以 治愈伤口披露。
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公开(公告)号：US08207118B2
公开(公告)日：2012-06-26
申请号：US12505361
申请日：2009-07-17
申请人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
发明人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
摘要： A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 μg/ml to about 100 μg/ml for a time sufficient to heal the wound is disclosed.
摘要翻译： 一种伤口愈合组合物，其包含一类多肽化合物，所述多肽化合物具有每链5至120个氨基酸单元的多肽链。 组合物包括携带多肽化合物的药物介质，例如水溶液，悬浮液，分散体，药膏，软膏，凝胶，霜剂，洗剂，喷雾剂或糊剂。 另外，一种施用伤口愈合组合物的方法，其包含一类具有多肽链的多肽化合物，所述多肽化合物具有约1μg/ ml至约100μg/ ml浓度的每链5至120个氨基酸单元，时间足以 治愈伤口披露。
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公开(公告)号：US20110082082A1
公开(公告)日：2011-04-07
申请号：US12505361
申请日：2009-07-17
申请人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
发明人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
摘要： A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 pg/ml to about 100 μg/ml for a time sufficient to heal the wound is disclosed.
摘要翻译： 一种伤口愈合组合物，其包含一类多肽化合物，所述多肽化合物具有每链5至120个氨基酸单元的多肽链。 组合物包括携带多肽化合物的药物介质，例如水溶液，悬浮液，分散体，药膏，软膏，凝胶，霜剂，洗剂，喷雾剂或糊剂。 另外，一种施用伤口愈合组合物的方法，其包含一类多肽化合物，所述多肽化合物具有多肽链，每个链具有约5至120个氨基酸单位，浓度为约1μg/ ml至约100μg/ ml，时间足以 治愈伤口披露。
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公开(公告)号：US08455443B2
公开(公告)日：2013-06-04
申请号：US13484162
申请日：2012-05-30
申请人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
发明人： Wei Li , Mei Chen , David T. Woodley , Chieh-Fang Cheng
摘要： A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 μg/ml to about 100 μg/ml for a time sufficient to heal the wound is disclosed.
摘要翻译： 一种伤口愈合组合物，其包含一类多肽化合物，所述多肽化合物具有每链5至120个氨基酸单元的多肽链。 组合物包括携带多肽化合物的药物介质，例如水溶液，悬浮液，分散体，药膏，软膏，凝胶，霜剂，洗剂，喷雾剂或糊剂。 另外，一种施用伤口愈合组合物的方法，所述伤口愈合组合物包含一类多肽化合物，所述多肽化合物具有多肽链，每个链具有5至120个氨基酸单位，浓度为约1mug / ml至约100mug / ml，持续足够的时间 治愈伤口披露。
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5.发明申请FRAGMENT OF SECRETED HEAT SHOCK PROTEIN-90ALPHA (Hsp90ALPHA) AS VACCINES OR EPITOPE FOR MONOCLONAL ANTIBODY DRUGS OR TARGET FOR SMALL MOLECULE DRUGS AGAINST A RANGE OF SOLID HUMAN TUMORS 审中-公开分散的热休克蛋白-90ALPHA（Hsp90ALPHA）作为疫苗或抗生素用于单克隆抗体药物或靶向小分子药物对抗人类肿瘤范围的片段公开(公告)号：US20120121595A1
公开(公告)日：2012-05-17
申请号：US13271076
申请日：2011-10-11
申请人： Wei Li , David T. Woodley , Mei Chen
发明人： Wei Li , David T. Woodley , Mei Chen
IPC分类号： A61K39/395 , C12N15/12 , C07K16/18 , A61K39/00 , A61K31/7105 , C12Q1/68 , A61P35/00 , A61P35/04 , C12N15/63 , C12N1/21 , C12N5/10 , G01N33/566 , C07K7/08 , A61K31/713
CPC分类号： C07K14/435 , A61K31/713 , A61K39/0005 , C07K14/47 , C07K16/18 , C07K2317/76 , G01N33/57484 , G01N33/92 , G01N2333/70596 , G01N2500/10
摘要： The invention provides methods for treating HIF-1α-overexpressing human tumors, inhibiting HIF-1α-overexpressing tumor invasion and preventing tumor metastasis, and/or promoting tumor prophylaxis, using various types of inhibitors against the Hsp90α from the tumors.
摘要翻译： 本发明提供使用各种类型的针对肿瘤Hsp90α的抑制剂治疗HIF-1α-过表达人类肿瘤，抑制HIF-1α-过表达肿瘤浸润和预防肿瘤转移和/或促进肿瘤预防的方法。
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公开(公告)号：US20100035815A1
公开(公告)日：2010-02-11
申请号：US12522446
申请日：2008-01-08
申请人： Wei Li , Mei Chen , David T. Woodley
发明人： Wei Li , Mei Chen , David T. Woodley
CPC分类号： A61K9/0014 , A61K38/1709 , A61L26/0066 , A61L2300/252 , A61L2300/412
摘要： A wound healing composition comprising an amount of heat shock protein effective to promote wound healing and a method thereof to apply the composition. A preferred heat shock protein is either full-length hsp90α or the middle domain plus the charged sequence of hsp90α. The composition is topically applied to skin wounds, covering the outer surface of the wound. The heat shock protein acts by promoting migration of both human epidermal keratinocyte and dermal fibroblasts to the wound in order to close, heal, and remodel the wound.
摘要翻译： 一种伤口愈合组合物，其包含一定量的有效促进伤口愈合的热休克蛋白及其施用该组合物的方法。 优选的热休克蛋白是全长hsp90α或中间结构域加上hsp90α的带电序列。 组合物局部施用于皮肤伤口，覆盖伤口的外表面。 热休克蛋白通过促进人类表皮角质形成细胞和真皮成纤维细胞迁移到伤口来起作用，以关闭，愈合和改造伤口。
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公开(公告)号：US08410055B2
公开(公告)日：2013-04-02
申请号：US13210200
申请日：2011-08-15
申请人： Wei Li , Mei Chen , David T. Woodley
发明人： Wei Li , Mei Chen , David T. Woodley
CPC分类号： A61K9/0014 , A61K38/1709 , A61L26/0066 , A61L2300/252 , A61L2300/412
摘要： A wound healing composition comprising an amount of heat shock protein effective to promote wound healing and a method thereof to apply the composition. A preferred heat shock protein is either full-length hsp90α or the middle domain plus the charged sequence of hsp90α. The composition is topically applied to skin wounds, covering the outer surface of the wound. The heat shock protein acts by promoting migration of both human epidermal keratinocyte and dermal fibroblasts to the wound in order to close, heal, and remodel the wound.
摘要翻译： 一种伤口愈合组合物，其包含一定量的有效促进伤口愈合的热休克蛋白及其施用该组合物的方法。 优选的热休克蛋白是全长hsp90α或中间结构域加上hsp90α的带电序列。 组合物局部施用于皮肤伤口，覆盖伤口的外表面。 热休克蛋白通过促进人类表皮角质形成细胞和真皮成纤维细胞迁移到伤口来起作用，以关闭，愈合和改造伤口。
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公开(公告)号：US08022037B2
公开(公告)日：2011-09-20
申请号：US12522446
申请日：2008-01-08
申请人： Wei Li , Mei Chen , David T. Woodley
发明人： Wei Li , Mei Chen , David T. Woodley
CPC分类号： A61K9/0014 , A61K38/1709 , A61L26/0066 , A61L2300/252 , A61L2300/412
摘要： A wound healing composition comprising an amount of heat shock protein effective to promote wound healing and a method thereof to apply the composition. A preferred heat shock protein is either full-length hsp90α or the middle domain plus the charged sequence of hsp90α. The composition is topically applied to skin wounds, covering the outer surface of the wound. The heat shock protein acts by promoting migration of both human epidermal keratinocyte and dermal fibroblasts to the wound in order to close, heal, and remodel the wound.
摘要翻译： 一种伤口愈合组合物，其包含一定量的有效促进伤口愈合的热休克蛋白及其施用该组合物的方法。 优选的热休克蛋白是全长hsp90α或中间结构域加上hsp90α的带电序列。 组合物局部施用于皮肤伤口，覆盖伤口的外表面。 热休克蛋白通过促进人类表皮角质形成细胞和真皮成纤维细胞迁移到伤口来起作用，以关闭，愈合和改造伤口。
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公开(公告)号：US20240317854A1
公开(公告)日：2024-09-26
申请号：US18550537
申请日：2022-03-17
申请人： Philip E. Brandish , Mei Chen , Andrey Loboda , Michael Nebozhyn, III , Cai Wu , Daping Zhang , Jie Zhang-Hoover
发明人： Philip E. Brandish , Mei Chen , Andrey Loboda , Michael Nebozhyn, III , Cai Wu , Daping Zhang , Jie Zhang-Hoover
IPC分类号： C07K16/28 , A61K31/337 , A61K31/7068 , A61K39/00 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2803 , A61K31/337 , A61K31/7068 , A61K39/3955 , A61P35/00 , C07K16/2818 , A61K2039/505 , A61K2039/507 , A61K2039/545
摘要： This disclosure relates to methods for treating solid tumors in a patient identified as having metastatic triple negative breast cancer, glioblastoma, metastatic pancreatic ductal adenocarcinoma, metastatic soft tissue sarcoma, or metastatic non-squamous non-small cell lung carcinoma, comprising administering an anti-ILT3 antigen binding protein, or antigen binding fragment, and an anti-PD1 antigen binding protein, or antigen binding fragment, to the patient every three weeks (Q3W).
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公开(公告)号：US10711052B2
公开(公告)日：2020-07-14
申请号：US13657594
申请日：2012-10-22
申请人： Mei Chen , David Woodley
发明人： Mei Chen , David Woodley
摘要： The present invention discloses a method for treating wounds and for accelerating the healing of wounds by administering an effective amount of a pharmaceutical composition containing type VII collagen protein, mini-C7 protein, variants thereof or any combinations thereof. The pharmaceutical composition may be administered through a variety of routes including intravenous injection, topical application, or oral ingestion. The method may further include administering a genetically modified fibroblast capable of expressing type VII collagen protein, mini-C7 protein, variants thereof or small growth factors to achieve synergistic healing effect.
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