公开(公告)号：US20120231969A1

公开(公告)日：2012-09-13

申请号：US13497895

申请日：2010-09-23

申请人： Wei-Wu He ,  Donghui Ma ,  Youmin Shu ,  Zairen Sun

发明人： Wei-Wu He ,  Donghui Ma ,  Youmin Shu ,  Zairen Sun

IPC分类号： C40B30/04 ,  C40B40/10 ,  C40B50/06

CPC分类号： G01N33/6845

摘要： Illustrative embodiments herein disclosed relate to protein arrays, methods for making the arrays and methods for using them, among others. In some embodiments known proteins representing at least 50% of the loci in the human genome are arrayed in known positions on a support. In some embodiments arrays are made of proteins purified from cell lysates by affinity binding to the support. In some embodiments protein arrays are used to decode the binding specificity of antibodies. In some embodiments protein arrays are used to diagnose auto-immune disorders. Many other embodiments and general features are disclosed.

摘要翻译： 本文公开的说明性实施方案涉及蛋白质阵列，制备阵列的方法及其使用方法等。 在一些实施方案中，代表人类基因组中至少50％的位点的已知蛋白质排列在载体上的已知位置。 在一些实施方案中，阵列由通过亲和结合载体从细胞裂解物纯化的蛋白质制成。 在一些实施方案中，蛋白质阵列用于解码抗体的结合特异性。 在一些实施方案中，蛋白质阵列用于诊断自身免疫疾病。 公开了许多其它实施例和一般特征。

公开(公告)号：US20060241015A1

公开(公告)日：2006-10-26

申请号：US10502394

申请日：2003-01-24

申请人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Wufang Fan ,  Youmin Shu

发明人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Wufang Fan ,  Youmin Shu

IPC分类号： A61K38/17 ,  G06Q10/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82

CPC分类号： G01N33/574 ,  A61K38/00 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/136 ,  G06Q50/22 ,  Y02A90/22 ,  Y02A90/26

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially expressed in prostate and breast cancers and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., cancers.

摘要翻译： 本发明涉及新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等中的应用。多核苷酸是差异化的 在前列腺癌和乳腺癌中表达，因此可用于多种方式，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性， 等等，癌症。

公开(公告)号：US20060026700A1

公开(公告)日：2006-02-02

申请号：US10511538

申请日：2003-04-15

申请人： Gilbert Jay ,  Richard Lebovitz ,  Youmin Shu ,  Zairen Sun ,  Meng Wu

发明人： Gilbert Jay ,  Richard Lebovitz ,  Youmin Shu ,  Zairen Sun ,  Meng Wu

IPC分类号： A01K67/027 ,  A61K48/00 ,  C12Q1/68

CPC分类号： C12Q1/6881 ,  A61K38/00 ,  C07K14/723 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates to genes and genes clusters which are expressed in a tissue specific maner. For example, the invention relates to a group of genes encoding GPCR-like receptors that are involved in the function and activity of the immune system. These genes are organized into a discrete cluster at chromosomal location 1q22 (the “immune gene complex”) and span about 700 kb of DNA. The region closest to the centromere comprises genes that are expressed predominantly in the thymus, while the distal region comprises genes which are expressed predominantly in the bone marrow and other hematopoietic cells. Another cluster of GPCR genes is located at chromosomal band 11q24. These genes are expressed predominantly in pancreatic tissue, establishing this region of chromosome 11 as a unique gene complex involved in pancreatic function. A cluster of transmembrane and GPCR-type receptor genes is also located at chromosomal band 11q12.2. These genes are expressed predominantly in the spleen (hence, “spleen gene” cluster), as well as other tissues of the immune and reticuloendothelial system (RES), indicating that establishing this region of the chromosome is involved in spleen, lymphoid, and/or reticuloendothelial function. Finally, genes coding for membrane proteins have been identified which are expressed selectively in bone marrow, kidney, pancreas, and retina.

摘要翻译： 本发明涉及在组织特异性施肥器中表达的基因和基因簇。 例如，本发明涉及编码参与免疫系统的功能和活性的GPCR样受体的一组基因。 这些基因被组织成染色体位置1q22（“免疫基因复合体”）并跨越约700kb DNA的离散簇。 最靠近着丝粒的区域包括主要在胸腺中表达的基因，而远端区域包含主要在骨髓和其他造血细胞中表达的基因。 另一组GPCR基因位于染色体条带11q24。 这些基因主要在胰腺组织中表达，将该染色体11区域作为涉及胰腺功能的独特基因复合体。 跨膜和GPCR型受体基因簇也位于染色体条带11q12.2。 这些基因主要在脾脏（因此，“脾基因”簇）以及免疫和网状内皮系统（RES）的其他组织中表达，表明建立该染色体区域涉及脾，淋巴和/ 或网状内皮功能。 最后，已经鉴定了编码膜蛋白的基因，其在骨髓，肾，胰腺和视网膜中选择性表达。

公开(公告)号：US20050120393A1

公开(公告)日：2005-06-02

申请号：US10485555

申请日：2002-08-02

申请人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Youmin Shu ,  Wufang Fan

发明人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Youmin Shu ,  Wufang Fan

IPC分类号： A01K67/00 ,  C07H21/04 ,  C07K14/47 ,  C07K14/705 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/574 ,  G06F17/60

CPC分类号： C07K14/47 ,  A01K2267/0331 ,  C07K14/4702 ,  C07K14/705 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/5091 ,  G01N33/57434 ,  G01N2500/10 ,  G01N2800/342

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in prostate and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions relating to prostate, such as prostate cancers, as well as other disease and conditions.

摘要翻译： 本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学，病理学和医学等方面的应用。 多核苷酸在前列腺中表达，因此可用于多种方式，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定等等的倾向 ，与前列腺相关的疾病和病症，如前列腺癌，以及其他疾病和病症。

公开(公告)号：US20050055733A1

公开(公告)日：2005-03-10

申请号：US10482838

申请日：2002-07-08

申请人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Youmin Shu ,  Wufang Fan

发明人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Youmin Shu ,  Wufang Fan

IPC分类号： C07K14/47 ,  C12Q1/68 ,  A01K67/00 ,  C07K14/705

CPC分类号： C07K14/47

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in small intestine or colon and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions relating to small intestine or colon.

摘要翻译： 本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学，病理学和医学等方面的应用。 多核苷酸在小肠或结肠中表达，因此可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性 等等，与小肠或结肠相关的疾病和病症。

公开(公告)号：US06780595B2

公开(公告)日：2004-08-24

申请号：US10082272

申请日：2002-02-26

申请人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Xuan Li ,  Gilbert Jay

发明人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Xuan Li ,  Gilbert Jay

IPC分类号： C12Q168

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G06Q30/0601

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.

摘要翻译： 本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学和医学等方面的应用。多核苷酸被表达 因此在各种方式中有用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病的易感性等 和心脏和眼睛的条件。

公开(公告)号：US20050019818A1

公开(公告)日：2005-01-27

申请号：US10921807

申请日：2004-08-20

申请人： Youmin Shu ,  Wufang Fan ,  Karl Kovacs ,  Xuan Li ,  Gilbert Jay

发明人： Youmin Shu ,  Wufang Fan ,  Karl Kovacs ,  Xuan Li ,  Gilbert Jay

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/10 ,  C12P21/04

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G06Q30/0601

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.

摘要翻译： 本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学和医学等方面的应用。多核苷酸被表达 因此在各种方式中有用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病的易感性等 和心脏和眼睛的条件。

公开(公告)号：US06455292B1

公开(公告)日：2002-09-24

申请号：US09930181

申请日：2001-08-16

申请人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Michael Zidanic ,  Gilbert Jay

发明人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Michael Zidanic ,  Gilbert Jay

IPC分类号： C12N912

CPC分类号： C12N9/1205 ,  G01N33/573 ,  G01N2333/9121

摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to diseases and conditions, especially relating to brain and pancreas.

摘要翻译： 本发明涉及新型多核苷酸的所有方面，其编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学，病理学和医学中的应用。 多核苷酸在脑和胰腺中表达，因此可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性 对疾病和病症，特别是与脑和胰腺有关。

公开(公告)号：US07115393B2

公开(公告)日：2006-10-03

申请号：US10164717

申请日：2002-06-10

申请人： Youmin Shu ,  Xuan Li ,  Anthony C. Yee ,  Gilbert Jay

发明人： Youmin Shu ,  Xuan Li ,  Anthony C. Yee ,  Gilbert Jay

IPC分类号： C07K14/72 ,  C12N15/12

CPC分类号： C07K14/47

摘要： The present invention relates to all facets of novel polynucleotides for melanocortin-1 receptors, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions especially relating to melanocortin-1, such as melanoma, pigmentation disorders and conditions, inflammation, etc.

摘要翻译： 本发明涉及用于黑皮质素-1受体的新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等方面的应用 多核苷酸可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病等的易感性，以及 特别是与黑皮质素-1有关的病症，如黑素瘤，色素沉着病和病症，炎症等。

公开(公告)号：US20050120855A1

公开(公告)日：2005-06-09

申请号：US10729061

申请日：2003-12-06

申请人： Youmin Shu

发明人： Youmin Shu

IPC分类号： A61B17/32 ,  B26F1/14 ,  B26F1/32

CPC分类号： A61B17/32053 ,  B26F1/32 ,  Y10T83/2122 ,  Y10T83/9423

摘要： The present invention relates to all facets of a novel cutting tool designed to retrieving gel slice from an agarose gel and poly-acrylamide gel. The cutting tool is made of plastics or metal materials and consists of a tool body and a plug. The upper end of the rectangle tube is open. A plug is inserted into the rectangle tube from the upper end of the tube to form the cutting tool. The rectangle shape and the plug of the cutting tool make gel-cutting and gel-ejecting much easier and more precise.

摘要翻译： 本发明涉及设计用于从琼脂糖凝胶和聚丙烯酰胺凝胶中回收凝胶切片的新型切削工具的所有方面。 切割工具由塑料或金属材料制成，由工具主体和插头组成。 矩形管的上端开放。 从管的上端将插头插入矩形管中以形成切割工具。 切割工具的矩形和插头使凝胶切割和凝胶喷射更加容易和精确。