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15 条记录 (耗时 0.037 秒)

    Cancer genes
    1.
    发明申请
    Cancer genes 审中-公开
    癌症基因

    公开(公告)号：US20060241015A1

    公开(公告)日：2006-10-26

    申请号：US10502394

    申请日：2003-01-24

    申请人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Wufang Fan ,  Youmin Shu

    发明人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Wufang Fan ,  Youmin Shu

    IPC分类号： A61K38/17 ,  G06Q10/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82

    CPC分类号： G01N33/574 ,  A61K38/00 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/136 ,  G06Q50/22 ,  Y02A90/22 ,  Y02A90/26

    摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially expressed in prostate and breast cancers and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., cancers.

    摘要翻译： 本发明涉及新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等中的应用。多核苷酸是差异化的 在前列腺癌和乳腺癌中表达，因此可用于多种方式，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性， 等等，癌症。

    Tissue specific genes and gene clusters
    2.
    发明申请
    Tissue specific genes and gene clusters 审中-公开
    组织特异性基因和基因簇

    公开(公告)号：US20060026700A1

    公开(公告)日：2006-02-02

    申请号：US10511538

    申请日：2003-04-15

    申请人： Gilbert Jay ,  Richard Lebovitz ,  Youmin Shu ,  Zairen Sun ,  Meng Wu

    发明人： Gilbert Jay ,  Richard Lebovitz ,  Youmin Shu ,  Zairen Sun ,  Meng Wu

    IPC分类号： A01K67/027 ,  A61K48/00 ,  C12Q1/68

    CPC分类号： C12Q1/6881 ,  A61K38/00 ,  C07K14/723 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The present invention relates to genes and genes clusters which are expressed in a tissue specific maner. For example, the invention relates to a group of genes encoding GPCR-like receptors that are involved in the function and activity of the immune system. These genes are organized into a discrete cluster at chromosomal location 1q22 (the “immune gene complex”) and span about 700 kb of DNA. The region closest to the centromere comprises genes that are expressed predominantly in the thymus, while the distal region comprises genes which are expressed predominantly in the bone marrow and other hematopoietic cells. Another cluster of GPCR genes is located at chromosomal band 11q24. These genes are expressed predominantly in pancreatic tissue, establishing this region of chromosome 11 as a unique gene complex involved in pancreatic function. A cluster of transmembrane and GPCR-type receptor genes is also located at chromosomal band 11q12.2. These genes are expressed predominantly in the spleen (hence, “spleen gene” cluster), as well as other tissues of the immune and reticuloendothelial system (RES), indicating that establishing this region of the chromosome is involved in spleen, lymphoid, and/or reticuloendothelial function. Finally, genes coding for membrane proteins have been identified which are expressed selectively in bone marrow, kidney, pancreas, and retina.

    摘要翻译： 本发明涉及在组织特异性施肥器中表达的基因和基因簇。 例如，本发明涉及编码参与免疫系统的功能和活性的GPCR样受体的一组基因。 这些基因被组织成染色体位置1q22（“免疫基因复合体”）并跨越约700kb DNA的离散簇。 最靠近着丝粒的区域包括主要在胸腺中表达的基因，而远端区域包含主要在骨髓和其他造血细胞中表达的基因。 另一组GPCR基因位于染色体条带11q24。 这些基因主要在胰腺组织中表达，将该染色体11区域作为涉及胰腺功能的独特基因复合体。 跨膜和GPCR型受体基因簇也位于染色体条带11q12.2。 这些基因主要在脾脏（因此，“脾基因”簇）以及免疫和网状内皮系统（RES）的其他组织中表达，表明建立该染色体区域涉及脾，淋巴和/ 或网状内皮功能。 最后，已经鉴定了编码膜蛋白的基因，其在骨髓，肾，胰腺和视网膜中选择性表达。

    Histamine H2 receptor and uses
    3.
    发明授权
    Histamine H2 receptor and uses 有权
    组胺H2受体和用途

    公开(公告)号：US06953673B2

    公开(公告)日：2005-10-11

    申请号：US10017393

    申请日：2001-12-18

    申请人： Karl F. Kovacs ,  Gilbert Jay

    发明人： Karl F. Kovacs ,  Gilbert Jay

    IPC分类号： C07K14/72 ,  C12N15/12 ,  G01N33/74 ,  C07H21/04 ,  C07K14/00 ,  C12N15/00 ,  C12N15/63

    CPC分类号： G01N33/74 ,  C07K14/723 ,  G01N2500/10

    摘要： The present invention relates to the histamine H2 receptor (H2R), a member of the G-protein-coupled heptahelical receptor family. This novel H2 receptor codes for a novel carboxy-terminal tail which imparts important regulatory functions to the receptor, e.g., in down-regulation, signal transduction, and in coupling the activity of the H2R to downstream effector molecules, such as G-protein-coupled receptor kinases (GRK). The present invention relates to all facets of this new form of the H2R receptor, including nucleic acids that encode it, H2R polypeptides, binding-partners thereto, as well as its use in research, diagnosis, drug discovery, validation, and targeting, therapy, and clinical medicine.

    摘要翻译： 本发明涉及组蛋白H2受体（H2R），G-蛋白偶联的七叶受体家族的成员。 这种新的H2受体编码一个新的羧基末端尾巴，其赋予受体重要的调节功能，例如在下调，信号转导和将H2R的活性与下游效应分子如G-蛋白 - 偶联受体激酶（GRK）。 本发明涉及这种新形式的H2R受体的所有方面，包括编码它的核酸，H2R多肽，与其结合的伴侣，以及其在研究，诊断，药物发现，验证和靶向治疗中的用途 和临床医学。

    Small intestine and colon genes
    5.
    发明申请
    Small intestine and colon genes 审中-公开
    小肠和结肠基因

    公开(公告)号：US20050055733A1

    公开(公告)日：2005-03-10

    申请号：US10482838

    申请日：2002-07-08

    申请人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Youmin Shu ,  Wufang Fan

    发明人： Zairen Sun ,  Xuan Li ,  Gilbert Jay ,  Karl Kovacs ,  Youmin Shu ,  Wufang Fan

    IPC分类号： C07K14/47 ,  C12Q1/68 ,  A01K67/00 ,  C07K14/705

    CPC分类号： C07K14/47

    摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine, etc. The polynucleotides are expressed in small intestine or colon and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions relating to small intestine or colon.

    摘要翻译： 本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学，病理学和医学等方面的应用。 多核苷酸在小肠或结肠中表达，因此可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性 等等，与小肠或结肠相关的疾病和病症。

    Regulated prostate cancer genes
    6.
    发明授权
    Regulated prostate cancer genes 有权
    调节前列腺癌基因

    公开(公告)号：US06833247B2

    公开(公告)日：2004-12-21

    申请号：US10144198

    申请日：2002-05-14

    申请人： Zairen Sun ,  Xuan Li ,  Gilbert Jay

    发明人： Zairen Sun ,  Xuan Li ,  Gilbert Jay

    IPC分类号： C12Q168

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  Y02A90/26

    摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are differentially-regulated in prostate cancer and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, to prostate cancer.

    摘要翻译： 本发明涉及新型多核苷酸的所有方面，它们编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学和医学等中的应用。多核苷酸是差异化的 在前列腺癌中有调节作用，因此可以多种方式使用，包括但不限于分子标记物，药物靶标，检测，诊断，分期，监测，预后，预防或治疗，确定易感性等。 ，疾病和病症，前列腺癌。

    Rapid-screen cDNA library panels
    7.
    发明授权
    Rapid-screen cDNA library panels 有权
    快速筛选cDNA文库

    公开(公告)号：US06316193B1

    公开(公告)日：2001-11-13

    申请号：US09412565

    申请日：1999-10-05

    申请人： Wei-Wu He ,  Gilbert Jay

    发明人： Wei-Wu He ,  Gilbert Jay

    IPC分类号： C12Q168

    CPC分类号： C12N15/1034

    摘要： The present invention relates to a arrays of nucleic acid and methods of screening these arrays for desired nucleotide sequences. In a preferred embodiment of the invention, a desired cDNA clone can be obtained in three or less rounds of PCR screening. A master plate containing a population of cDNA, distributed in a plurality of wells, is screened for a desired clone by PCR. After a master well containing the desired cDNA is identified, a second plate containing a cDNA array of the master well can then be screened using the same PCR primers. Since the second plate contains about 50-fold to 100-fold fewer clones than the master plate, an expedient reduction in the number of candidates can be achieved in a single PCR step. The invention also relates to a super-master plate containing at least two, preferably more, different populations of cDNA obtainable from different sources of mRNA.

    摘要翻译： 本发明涉及核酸阵列和筛选所需核苷酸序列的这些阵列的方法。 在本发明的优选实施方案中，可以在三次或更少轮的PCR筛选中获得所需的cDNA克隆。 通过PCR筛选含有分布在多个孔中的cDNA群体的母板以获得期望的克隆。 鉴定含有所需cDNA的主孔后，可以使用相同的PCR引物筛选含有主孔cDNA序列的第二平板。 由于第二板含有比母板少约50倍至100倍的克隆，因此可以在单个PCR步骤中实现候选数目的有利的减少。 本发明还涉及含有可从不同mRNA来源获得的至少两个，优选更多不同种群的cDNA的超级主板。

    Human TBX20 gene and uses
    8.
    发明申请
    Human TBX20 gene and uses 审中-公开
    人类TBX20基因及用途

    公开(公告)号：US20050019818A1

    公开(公告)日：2005-01-27

    申请号：US10921807

    申请日：2004-08-20

    申请人： Youmin Shu ,  Wufang Fan ,  Karl Kovacs ,  Xuan Li ,  Gilbert Jay

    发明人： Youmin Shu ,  Wufang Fan ,  Karl Kovacs ,  Xuan Li ,  Gilbert Jay

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/10 ,  C12P21/04

    CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G06Q30/0601

    摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in heart and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions of the heart and eye.

    摘要翻译： 本发明涉及新型多核苷酸，它们编码的多肽，抗体及其特异性结合伴侣的所有方面及其在研究，诊断，药物发现，治疗，临床医学，法医学和医学等方面的应用。多核苷酸被表达 因此在各种方式中有用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定疾病的易感性等 和心脏和眼睛的条件。

    Full-length serine protein kinase in brain and pancreas
    9.
    发明授权
    Full-length serine protein kinase in brain and pancreas 有权
    脑和胰腺全长丝氨酸蛋白激酶

    公开(公告)号：US06455292B1

    公开(公告)日：2002-09-24

    申请号：US09930181

    申请日：2001-08-16

    申请人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Michael Zidanic ,  Gilbert Jay

    发明人： Youmin Shu ,  Wufang Fan ,  Karl F. Kovacs ,  Michael Zidanic ,  Gilbert Jay

    IPC分类号： C12N912

    CPC分类号： C12N9/1205 ,  G01N33/573 ,  G01N2333/9121

    摘要： The present invention relates to all facets of novel polynucleotides, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science, pathology, and medicine. The polynucleotides are expressed in brain and pancreas and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to diseases and conditions, especially relating to brain and pancreas.

    摘要翻译： 本发明涉及新型多核苷酸的所有方面，其编码的多肽，抗体及其特异性结合伴侣，以及它们在研究，诊断，药物发现，治疗，临床医学，法医学，病理学和医学中的应用。 多核苷酸在脑和胰腺中表达，因此可以多种方式使用，包括但不限于作为分子标志物，作为药物靶标，以及用于检测，诊断，分期，监测，预后，预防或治疗，确定易感性 对疾病和病症，特别是与脑和胰腺有关。