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    Ascorbate 2-polyphosphate esters and method of making same
    3.
    发明授权
    Ascorbate 2-polyphosphate esters and method of making same 失效
    抗坏血酸2-聚磷酸酯及其制备方法

    公开(公告)号：US4647672A

    公开(公告)日：1987-03-03

    申请号：US749081

    申请日：1985-06-25

    申请人： Paul A. Seib ,  Ming-Long Liao

    发明人： Paul A. Seib ,  Ming-Long Liao

    IPC分类号： A23L33/15 ,  A61K31/665 ,  A61P3/02 ,  C07D307/62 ,  C07F9/09 ,  C07F9/655

    CPC分类号： C07F9/65515

    摘要： A new stable derivative of ascorbic acid, ascorbate 2-polyphosphate, is disclosed, together with a high-yield method of synthesis thereof. The method preferably includes steps of reacting an ascorbic acid such as L-ascorbic acid or a derivative thereof such as 5,6-O-isopropylidene-L-ascorbic acid with salts of metaphosphoric acid in an aqueous system and in the presence of sufficient base to maintain the pH of the reaction mixture at a level of at least above 9 to obtain 2-polyphosphorylation of the ascorbic acid. In particularly preferred forms, 1 M L-ascorbic acid is reacted in water with 1.5-3 equivalent of sodium or potassium trimetaphosphate at a temperature of 25.degree.-55.degree. C., and an alkali metal hydroxide such as potassium hydroxide is intermittently added to the reaction mixture as needed over a 1-10 hr. reaction period to maintain the pH thereof at a level of about 10.5-12 during the entire reaction. After neutralization the reaction mixture contains no noxious or toxic materials, and the entire mixture may be added to food or feed. Pure salts of ascorbate 2-triphosphate can be isolated readily using conventional chromatographic techniques. It has also been found that the compounds of the invention are more difficult to oxidize, and release ascorbic acid and are more slowly hydrolyzed than the monophosphate derivative of ascorbic acid.

    摘要翻译： 公开了抗坏血酸，2-多磷酸抗坏血酸的新的稳定的衍生物，以及高产率的合成方法。 所述方法优选包括以下步骤：使水溶性体系中的抗坏血酸例如L-抗坏血酸或其衍生物如5,6-O-异亚丙基-L-抗坏血酸与偏磷酸盐反应，并在足够的碱 以将反应混合物的pH保持在至少高于9的水平以获得抗坏血酸的2-多磷酸化。 在特别优选的形式中，在25-55℃的温度下，1M水溶性抗坏血酸与1.5-3当量的三偏磷酸钠或钾反应，间歇地向碱金属氢氧化物如氢氧化钾中加入 在1-10小时内根据需要反应混合物。 在整个反应期间将pH保持在约10.5-12的水平。 中和后，反应混合物不含有毒或有毒物质，整个混合物可加入食品或饲料中。 使用常规色谱技术可以容易地分离出抗坏血酸盐2-三磷酸盐的纯盐。 还发现本发明的化合物比抗坏血酸的单磷酸酯衍生物更难氧化，释放出抗坏血酸，并且比水解的更缓慢。