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33 条记录 (耗时 0.026 秒)

    Trisubstituted Thiophenes as Progesterone Receptor Modulators
    1.
    发明申请
    Trisubstituted Thiophenes as Progesterone Receptor Modulators 审中-公开
    三取代噻吩作为孕酮受体调节剂

    公开(公告)号：US20090306118A1

    公开(公告)日：2009-12-10

    申请号：US12542135

    申请日：2009-08-17

    申请人： Weiqin Jiang ,  James J. Fiordeliso ,  Zhihua Sui

    发明人： Weiqin Jiang ,  James J. Fiordeliso ,  Zhihua Sui

    IPC分类号： A61K31/4436 ,  A61K31/438 ,  A61K31/4545 ,  A61P15/00 ,  A61P35/00

    CPC分类号： C07D491/10 ,  C07D409/04 ,  C07D409/14

    摘要： The present invention is directed to novel trisubstituted thiophene derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical usage of these compounds are related to hormonal contraception, the treatment and/or prevention of secondary dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon or prostate. Additional uses of the invention include stimulation of food intake.

    摘要翻译： 本发明涉及新颖的三取代噻吩衍生物，含有它们的药物组合物及其在治疗或预防由孕酮受体的激动剂和拮抗剂介导的病症和疾病中的用途。 这些化合物的临床应用与激素避孕有关，治疗和/或预防继发性痛经，闭经，功能失调的子宫出血，子宫平滑肌瘤，子宫内膜异位症; 多囊卵巢综合征，子宫内膜，卵巢，乳腺，结肠或前列腺的癌和腺癌。 本发明的额外用途包括刺激食物摄取。

    Indole derivatives useful as progesterone receptor modulators
    2.
    发明授权
    Indole derivatives useful as progesterone receptor modulators 有权
    吲哚衍生物可用作孕激素受体调节剂

    公开(公告)号：US07183309B2

    公开(公告)日：2007-02-27

    申请号：US11255444

    申请日：2005-10-21

    申请人： Weiqin Jiang ,  James J. Fiordeliso ,  Zhihua Sui

    发明人： Weiqin Jiang ,  James J. Fiordeliso ,  Zhihua Sui

    IPC分类号： A61K31/404 ,  C07D209/04

    CPC分类号： C07D209/30

    摘要： The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical uses of these compounds are related to contraception, the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minication of side effects of cyclid menstrual bleeding. Additional uses of the invention include stimulation of food intake.

    摘要翻译： 本发明涉及新颖的吲哚衍生物，含有它们的药物组合物及其用于治疗或预防由孕酮受体的激动剂和拮抗剂介导的病症和疾病。 这些化合物的临床应用与避孕，继发性闭经，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症的治疗和/或预防有关; 多囊卵巢综合征，子宫内膜癌，卵巢癌，乳腺癌，结肠癌，前列腺癌，腺瘤，子宫内膜异位症，副周围性月经出血副作用。 本发明的额外用途包括刺激食物摄取。

    Indole derivatives useful as progesterone receptor modulators
    9.
    发明申请
    Indole derivatives useful as progesterone receptor modulators 有权
    吲哚衍生物可用作孕激素受体调节剂

    公开(公告)号：US20060111427A1

    公开(公告)日：2006-05-25

    申请号：US11255444

    申请日：2005-10-21

    申请人： Weiqin Jiang ,  James Fiordeliso ,  Zhihua Sui

    发明人： Weiqin Jiang ,  James Fiordeliso ,  Zhihua Sui

    IPC分类号： A61K31/404 ,  C07D209/36

    CPC分类号： C07D209/30

    摘要： The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical uses of these compounds are related to contraception, the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minication of side effects of cyclid menstrual bleeding. Additional uses of the invention include stimulation of food intake.

    摘要翻译： 本发明涉及新颖的吲哚衍生物，含有它们的药物组合物及其在治疗或预防由孕酮受体的激动剂和拮抗剂介导的病症和疾病中的用途。 这些化合物的临床应用与避孕，继发性闭经，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症的治疗和/或预防有关; 多囊卵巢综合征，子宫内膜癌，卵巢癌，乳腺癌，结肠癌，前列腺癌，腺瘤，子宫内膜异位症，副周围性月经出血副作用。 本发明的额外用途包括刺激食物摄取。