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公开(公告)号：US07691865B2
公开(公告)日：2010-04-06
申请号：US10526839
申请日：2003-09-05
申请人： Wen-Cherng Lee , Mary Beth Carter , Lihong Sun , Paul Lyne , Claudio Chuaqui , Zhongli Zheng , Juswinder Singh , Paula Boriack-Sjodin
发明人： Wen-Cherng Lee , Mary Beth Carter , Lihong Sun , Paul Lyne , Claudio Chuaqui , Zhongli Zheng , Juswinder Singh , Paula Boriack-Sjodin
IPC分类号： A61K31/519 , C07D471/02 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： Compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I:
摘要翻译： 式I的化合物对Alk 5和/或Alk 4具有出人意料的高亲和力，并且可用作其拮抗剂，用于预防和/或治疗包括纤维化疾病在内的许多疾病。 在一个实施方案中，本发明的特征在于式I的化合物：
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公开(公告)号：US20100056505A1
公开(公告)日：2010-03-04
申请号：US12085380
申请日：2006-11-21
申请人： Wen-Cherng Lee , Mary Beth Carter , Claudio Chuaqui , Kevin Guckian , Edward Lin , Michael J. Choi , Zhan Deng , Paula Ann Boriack-Sjodin , Lihong Sun
发明人： Wen-Cherng Lee , Mary Beth Carter , Claudio Chuaqui , Kevin Guckian , Edward Lin , Michael J. Choi , Zhan Deng , Paula Ann Boriack-Sjodin , Lihong Sun
IPC分类号： A61K31/498 , C07D403/02 , C07D401/14 , C07D409/14 , C07D403/12 , C07D417/14 , C07D413/14 , A61K31/541 , A61K31/5377 , A61P43/00 , A61P35/00 , A61P9/00 , A61P9/12
CPC分类号： C07D403/04 , C07D401/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/14
摘要： The invention is related to compounds of formula (I) as antagonists of the TGFβ family type I receptors, Alk5 and/or AIk 4, compositions and methods of use. The compounds of formula (I) can be employed in the prevention and/or treatment of diseases such as fibrosis (e.g., renal fibrosis, pulmonary fibrosis, and hepatic fibrosis), progressive cancers, or other diseases for which reduction of TGFβ family signaling activity is desirable.
摘要翻译： 本发明涉及作为TGFβb拮抗剂的式（I）化合物; 家族I型受体，Alk5和/或AIk4，组合物和使用方法。 式（I）化合物可用于预防和/或治疗诸如纤维化（例如肾纤维化，肺纤维化和肝纤维化），进行性癌症或其它TGFβb的降低的疾病; 家庭信号传导活动是可取的。
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公开(公告)号：US06248713B1
公开(公告)日：2001-06-19
申请号：US08498237
申请日：1995-07-11
申请人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
发明人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
IPC分类号： A61K3803
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0202 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/0815 , C07K5/0819 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1024 , C07K14/78 , Y10S514/825 , Y10S514/826 , Y10S514/863 , Y10S514/866 , Y10S514/885 , Y10S514/903 , Y10S530/868
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
摘要翻译： 本发明涉及可用于抑制和预防细胞粘附和细胞粘附介导的病理学的新型化合物。 本发明还涉及包含这些化合物的药物制剂及其用于抑制和预防细胞粘附和细胞粘附介导的病理学的方法。 本发明的化合物和药物组合物可用作治疗剂或预防剂。 它们特别适用于治疗许多炎性和自身免疫性疾病。
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公开(公告)号：US06596687B1
公开(公告)日：2003-07-22
申请号：US09482296
申请日：2000-01-13
申请人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
发明人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
IPC分类号： A61K3803
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0202 , C07K5/021 , C07K5/06034 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/0815 , C07K5/0819 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1024 , C07K14/78 , Y10S514/825 , Y10S514/826 , Y10S514/863 , Y10S514/866 , Y10S514/885 , Y10S514/903 , Y10S530/868
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
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公开(公告)号：US06875743B1
公开(公告)日：2005-04-05
申请号：US09724139
申请日：2000-11-28
申请人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
发明人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
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公开(公告)号：US06239108B1
公开(公告)日：2001-05-29
申请号：US08983391
申请日：1998-08-10
申请人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
发明人： Ko-Chung Lin , Steven P. Adams , Alfredo C. Castro , Craig N. Zimmerman , Julio Hernan Cuervo , Wen-Cherng Lee , Charles E. Hammond , Mary Beth Carter , Ronald G. Almquist
IPC分类号： A61K3800
CPC分类号： C07K5/0819 , A61K38/00 , C07K5/06043 , C07K5/06113 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0817 , C07K5/0823 , C07K5/101 , C07K5/1013
摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
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