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    Methods for enhancing vascular patterns in cervical imagery
    1.
    发明申请
    Methods for enhancing vascular patterns in cervical imagery 失效
    增强宫颈图像血管模式的方法

    公开(公告)号：US20100040263A1

    公开(公告)日：2010-02-18

    申请号：US12228739

    申请日：2008-08-15

    申请人： Wenjing Li ,  Sankar Venkataraman ,  Ulf Gustafsson ,  John Taylor Hargrove

    发明人： Wenjing Li ,  Sankar Venkataraman ,  Ulf Gustafsson ,  John Taylor Hargrove

    IPC分类号： A61B5/00

    CPC分类号： G06T5/30 ,  G06T5/009 ,  G06T2207/30004 ,  G06T2207/30068

    摘要： A method of contrast enhancement for improved visualization of diagnostically important tissue structures, such as blood vessels. A texture analysis algorithm is applied to identify regions with a high likelihood of disease. Mathematical morphology operations are applied to identify areas of high and low brightness (intensity). The low intensity areas are then subtracted, and controllably variable amounts of the high intensity areas are added, controlled by a selectable tuning parameter, to produce an image with controllably variable visualization enhancement.

    摘要翻译： 一种对比度增强的方法，用于改善诊断上重要的组织结构如血管的可视化。 应用纹理分析算法识别疾病可能性高的地区。 应用数学形态学操作来识别高亮度和低亮度（强度）的区域。 然后减去低强度区域，并且通过可选择的调谐参数来控制可变量的高强度区域，以产生具有可控地可变的可视化增强的图像。

    Methods of contrast enhancement for images having blood vessel structures
    2.
    发明授权
    Methods of contrast enhancement for images having blood vessel structures 失效
    具有血管结构的图像的对比度增强方法

    公开(公告)号：US08351667B2

    公开(公告)日：2013-01-08

    申请号：US12228739

    申请日：2008-08-15

    申请人： Wenjing Li ,  Sankar Venkataraman ,  Ulf Gustafsson ,  John Taylor Hargrove

    发明人： Wenjing Li ,  Sankar Venkataraman ,  Ulf Gustafsson ,  John Taylor Hargrove

    IPC分类号： G06K9/18

    CPC分类号： G06T5/30 ,  G06T5/009 ,  G06T2207/30004 ,  G06T2207/30068

    摘要： A method of contrast enhancement for improved visualization of diagnostically important tissue structures, such as blood vessels. A texture analysis algorithm is applied to identify regions with a high likelihood of disease. Mathematical morphology operations are applied to identify areas of high and low brightness (intensity). The low intensity areas are then subtracted, and controllably variable amounts of the high intensity areas are added, controlled by a selectable tuning parameter, to produce an image with controllably variable visualization enhancement.

    摘要翻译： 一种对比度增强的方法，用于改善诊断上重要的组织结构如血管的可视化。 应用纹理分析算法识别疾病可能性高的地区。 应用数学形态学操作来识别高亮度和低亮度（强度）的区域。 然后减去低强度区域，并且通过可选择的调谐参数来控制可变量的高强度区域，以产生具有可控地可变的可视化增强的图像。

    Methods for detection and characterization of atypical vessels in cervical imagery
    3.
    发明申请
    Methods for detection and characterization of atypical vessels in cervical imagery 失效
    宫颈图像中非典型血管的检测和表征方法

    公开(公告)号：US20100027863A1

    公开(公告)日：2010-02-04

    申请号：US12221328

    申请日：2008-08-01

    申请人： Sankar Venkataraman ,  Wenjing Li ,  Ulf Peter Gustafsson

    发明人： Sankar Venkataraman ,  Wenjing Li ,  Ulf Peter Gustafsson

    IPC分类号： A61B5/00

    CPC分类号： A61B5/02007 ,  A61B1/00009 ,  A61B5/0084 ,  G06T7/0012 ,  G06T7/11 ,  G06T2207/30096 ,  G06T2207/30101

    摘要： The present invention discloses a method for the detection of atypical vessels in digital cervical imagery. A pre-processing stage is applied to enhance the contrast of blood vessel features compared to the surrounding tissue. Next, a segmentation stage is applied to identify regions of interest for atypical vessels using texture and gradient information. Finally, a post-processing stage (1) identifies other clinically relevant features in the cervical imager, and removes these features from the region of interest; and (2) uses color, size, and shape information to further refine the region of interest to eliminate false positives and determine a final region of interest. This automated method of atypical vessel detection is especially useful for diagnostic purposes such as cervical cancer detection.

    摘要翻译： 本发明公开了一种检测数字宫颈图像中非典型血管的方法。 应用预处理阶段来增强与周围组织相比的血管特征的对比度。 接下来，使用分割阶段来使用纹理和梯度信息来识别非典型血管的感兴趣区域。 最后，后处理阶段（1）识别子宫颈成像仪中的其他临床相关特征，并从感兴趣区域中去除这些特征; 和（2）使用颜色，大小和形状信息进一步细化感兴趣的区域以消除假阳性，并确定最终感兴趣的区域。 这种非典型血管检测的自动化方法对于诸如宫颈癌检测的诊断目的尤其有用。

    Methods for detection and characterization of atypical vessels in cervical imagery
    4.
    发明授权
    Methods for detection and characterization of atypical vessels in cervical imagery 失效
    宫颈图像中非典型血管的检测和表征方法

    公开(公告)号：US08090177B2

    公开(公告)日：2012-01-03

    申请号：US12221328

    申请日：2008-08-01

    申请人： Sankar Venkataraman ,  Wenjing Li ,  Ulf Peter Gustafsson

    发明人： Sankar Venkataraman ,  Wenjing Li ,  Ulf Peter Gustafsson

    IPC分类号： G06K9/00

    CPC分类号： A61B5/02007 ,  A61B1/00009 ,  A61B5/0084 ,  G06T7/0012 ,  G06T7/11 ,  G06T2207/30096 ,  G06T2207/30101

    摘要： The present invention discloses a method for the detection of atypical vessels in digital cervical imagery. A pre-processing stage is applied to enhance the contrast of blood vessel features compared to the surrounding tissue. Next, a segmentation stage is applied to identify regions of interest for atypical vessels using texture and gradient information. Finally, a post-processing stage (1) identifies other clinically relevant features in the cervical imager, and removes these features from the region of interest; and (2) uses color, size, and shape information to further refine the region of interest to eliminate false positives and determine a final region of interest. This automated method of atypical vessel detection is especially useful for diagnostic purposes such as cervical cancer detection.

    摘要翻译： 本发明公开了一种检测数字宫颈图像中非典型血管的方法。 应用预处理阶段来增强与周围组织相比的血管特征的对比度。 接下来，使用分割阶段来使用纹理和梯度信息来识别非典型血管的感兴趣区域。 最后，后处理阶段（1）识别子宫颈成像仪中的其他临床相关特征，并从感兴趣区域中去除这些特征; 和（2）使用颜色，大小和形状信息进一步细化感兴趣的区域以消除假阳性，并确定最终感兴趣的区域。 这种非典型血管检测的自动化方法对于诸如宫颈癌检测的诊断目的尤其有用。

    Method of automated image color calibration
    5.
    发明授权
    Method of automated image color calibration 失效
    自动图像色彩校准方法

    公开(公告)号：US08027533B2

    公开(公告)日：2011-09-27

    申请号：US12077659

    申请日：2008-03-19

    申请人： Wenjing Li ,  Marcelo Soto-Thompson ,  Ulf Gustafsson ,  Holger Lange

    发明人： Wenjing Li ,  Marcelo Soto-Thompson ,  Ulf Gustafsson ,  Holger Lange

    IPC分类号： G06K9/00

    CPC分类号： H04N1/6033 ,  H04N1/00045 ,  H04N1/401 ,  H04N1/6086

    摘要： A method of automated image calibration that corrects for non-uniform illumination and calibrates color that is simple, fast, automated, accurate and reliable. A gray balance algorithm is applied to correct for non-uniform illumination and a color calibration algorithm is then applied to calibrate the human subject data. The system has been applied in multiple clinical sites with different instruments.

    摘要翻译： 一种自动图像校准方法，用于校正不均匀照明并校准简单，快速，自动，准确和可靠的颜色。 应用灰度平衡算法来校正不均匀照明，然后应用颜色校准算法来校准人类受试者数据。 该系统已应用于具有不同仪器的多个临床部位。

    Method of automated image color calibration
    6.
    发明申请
    Method of automated image color calibration 失效
    自动图像色彩校准方法

    公开(公告)号：US20080240558A1

    公开(公告)日：2008-10-02

    申请号：US12077659

    申请日：2008-03-19

    申请人： Wenjing Li ,  Marcelo Soto-Thompson ,  Ulf Gustafsson ,  Holger Lange

    发明人： Wenjing Li ,  Marcelo Soto-Thompson ,  Ulf Gustafsson ,  Holger Lange

    IPC分类号： G06K9/00

    CPC分类号： H04N1/6033 ,  H04N1/00045 ,  H04N1/401 ,  H04N1/6086

    摘要： A method of automated image calibration that corrects for non-uniform illumination and calibrates color that is simple, fast, automated, accurate and reliable. A gray balance algorithm is applied to correct for non-uniform illumination and a color calibration algorithm is then applied to calibrate the human subject data. The system has been applied in multiple clinical sites with different instruments.

    摘要翻译： 一种自动图像校准方法，用于校正不均匀照明并校准简单，快速，自动，准确和可靠的颜色。 应用灰度平衡算法来校正不均匀照明，然后应用颜色校准算法来校准人类受试者数据。 该系统已应用于具有不同仪器的多个临床部位。

    3D retinal disruptions detection using optical coherence tomography
    9.
    发明授权
    3D retinal disruptions detection using optical coherence tomography 有权
    使用光学相干断层扫描的3D视网膜中断检测

    公开(公告)号：US08622548B2

    公开(公告)日：2014-01-07

    申请号：US13299219

    申请日：2011-11-17

    申请人： Cheng-en Guo ,  Ben Jang ,  Wenjing Li

    发明人： Cheng-en Guo ,  Ben Jang ,  Wenjing Li

    IPC分类号： A61B3/14 ,  A61B3/00

    CPC分类号： A61B3/102 ,  G06T7/11 ,  G06T7/187 ,  G06T2207/10101 ,  G06T2207/20156

    摘要： System and method for 3D retinal disruption/elevation detection, measurement and presentation using Optical Coherence Tomography (OCT) are provided. The present invention is capable of detecting and measuring the abnormal changes of retinal layers (retinal disruptions), caused by retinal diseases, such as hard drusen, soft drusen, Pigment Epithelium Detachment (PED), Choroidal Neovascularization (CNV), Geographic Atrophy (GA), intra retinal fluid space, and exudates etc. The presentations of the results are provided with quantitative measurements of disruptions in retina and can be used for diagnosis and treatment of retinal diseases.

    摘要翻译： 提供了使用光学相干断层扫描（OCT）的3D视网膜中断/仰角检测，测量和呈现的系统和方法。 本发明能够检测和测量视网膜疾病引起的视网膜层异常变化（视网膜中断），如硬玻璃疣，软玻璃疣，色素上皮分离（PED），脉络膜新血管形成（CNV），地理萎缩（GA） ），视网膜内液体空间和渗出液等。结果的呈现提供了视网膜中断的定量测量，可用于视网膜疾病的诊断和治疗。