专利检索 ap:("Wenyan Wang" OR "Shahriar Shane Taremi" OR "Winifred W. Prosise" OR "Paul Reichert" OR "Charles A. Lesburg" OR "Vincent S. Madison" OR "Kuo-Chi Cheng") AND inv:"Kuo-Chi Cheng" 第 1 页

1.

发明授权
Pregnane X receptor compositions, crystals and uses thereof 失效
标题翻译：孕烷X受体组合物，晶体及其用途

公开(公告)号：US07785879B1

公开(公告)日：2010-08-31

申请号：US11522698

申请日：2006-09-18

申请人： Wenyan Wang , Shahriar Shane Taremi , Winifred W. Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng

发明人： Wenyan Wang , Shahriar Shane Taremi , Winifred W. Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng

IPC分类号： C12N5/00 , C12N1/00 , C12N1/20 , C12P21/06 , C07H21/04 , C07K14/00

CPC分类号： C07K14/70567 , C07K14/4705 , C07K2319/31

摘要： The present invention relates, inter alia, to PXR polypeptides and crystals that are useful, for example, for crystallization and in assays for identification of modulators of PXR.

摘要翻译： 本发明尤其涉及PXR多肽和晶体，其可用于例如结晶和用于鉴定PXR调节剂的测定。

2.

发明授权
Crystal of pregnane X receptor fused to steroid receptor coactivator-1 失效
标题翻译：孕激素X受体的结晶融合到类固醇受体共激活因子-1

公开(公告)号：US08048663B2

公开(公告)日：2011-11-01

申请号：US12815817

申请日：2010-06-15

申请人： Wenyan Wang , Shahriar Shane Taremi , Winifred Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng

发明人： Wenyan Wang , Shahriar Shane Taremi , Winifred Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng

IPC分类号： C12N9/12 , G01N23/20

CPC分类号： C07K14/70567 , C07K14/4705 , C07K2319/31

摘要： The present invention relates to Pregnane X receptor (PXR) polypeptides and crystals that are useful, for example, for crystallization and in assays for identification of modulators of PXR.

摘要翻译： 本发明涉及可用于例如结晶和用于鉴定PXR调节剂的测定中的孕烷X受体（PXR）多肽和晶体。

3.

发明申请
Pregnane X Receptor Compositions, Crystals and Uses Thereof 失效
标题翻译：孕烷X受体组合物，晶体及其用途

公开(公告)号：US20100286372A1

公开(公告)日：2010-11-11

申请号：US12815817

申请日：2010-06-15

申请人： Wenyan Wang , Shahriar Shane Taremi , Winifred Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng

发明人： Wenyan Wang , Shahriar Shane Taremi , Winifred Prosise , Paul Reichert , Charles A. Lesburg , Vincent S. Madison , Kuo-Chi Cheng

IPC分类号： C07K14/00

CPC分类号： C07K14/70567 , C07K14/4705 , C07K2319/31

摘要： The present invention relates, inter alia, to PXR polypeptides and crystals that are useful, for example, for crystallization and in assays for identification of modulators of PXR.

摘要翻译： 本发明尤其涉及PXR多肽和晶体，其可用于例如结晶和用于鉴定PXR调节剂的测定。

4.

发明申请
Liver/plasma concentration ratio for dosing hepatitis C virus protease inhibitor 审中-公开
标题翻译：给予丙型肝炎病毒蛋白酶抑制剂的肝/血浆浓度比

公开(公告)号：US20070021351A1

公开(公告)日：2007-01-25

申请号：US11444055

申请日：2006-05-31

申请人： Ronald White , Kuo-Chi Cheng

发明人： Ronald White , Kuo-Chi Cheng

IPC分类号： A61K38/05 , A61K38/04 , A61K31/4709

CPC分类号： A61K38/04 , A61K31/4709 , A61K38/05 , A61K38/06 , A61K38/08 , A61K38/12

摘要： Compositions and therapeutic combinations are provided including at least one compound selected from the group consisting of compounds of Formulae I to XXVI as defined herein as well as methods of treatment, prevention or amelioration of one or more symptoms of hepatitis C, treating disorders associated with HCV virus, modulating activity of HCV protease, in which liver to plasma concentration ratio of the compound ranges from about 2:1 to about 10:1.

摘要翻译： 提供组合物和治疗组合，包括至少一种选自本文定义的式I至XXVI化合物的化合物以及治疗，预防或改善丙型肝炎一种或多种症状的方法，治疗与HCV相关的病症病毒，调节HCV蛋白酶的活性，其中化合物的肝脏至血浆浓度比范围为约2:1至约10:1。