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31 条记录 (耗时 0.019 秒)

    Cyclic derivatives of alkyl dihydroxyalkylxanthenes
    6.
    发明授权
    Cyclic derivatives of alkyl dihydroxyalkylxanthenes 失效
    烷基二羟基烷基呫吨的环状衍生物

    公开(公告)号：US4713455A

    公开(公告)日：1987-12-15

    申请号：US848139

    申请日：1986-04-04

    申请人： Harald Furrer ,  Hiristo Anagnostopulos ,  Ulrich Gebert

    发明人： Harald Furrer ,  Hiristo Anagnostopulos ,  Ulrich Gebert

    IPC分类号： A61K31/52 ,  A61K31/522 ,  A61P11/08 ,  C07C21/04 ,  C07C29/10 ,  C07C31/42 ,  C07D303/08 ,  C07D317/16 ,  C07D317/20 ,  C07D473/06 ,  C07D473/08 ,  C07D473/10 ,  C07D405/06

    CPC分类号： C07D473/08 ,  C07C29/10 ,  C07C31/42 ,  C07D303/08 ,  C07D317/16 ,  C07D317/20 ,  C07D473/06

    摘要： Compounds of the formula ##STR1## wherein one of the radicals R.sup.1, R.sup.2 or R.sup.3 denotes a straight-chain alkyl group having 4 to 8 C atoms and two vicinal hydroxyl groups in the .omega.,.omega.-1 or .omega.-1,.omega.-2 positions and the two other radicals represent straight-chain or branched alkyl groups having up to 12 C atoms in the position of R.sup.1 and R.sup.3 and up to 4 C atoms in the position of R.sup.2, the total of C atoms in these two alkyl substituents being a maximum of 14, are prepared by oxidation of the corresponding alkenylxanthines and by alkylation with compounds which introduce the dihydroxyalkyl radical or a precursor thereof. The dihydroxyalkyldialkylxanthines are suitable for the treatment of obstructive respiratory tract diseases.

    摘要翻译： 式（I）的化合物其中基团R 1，R 2或R 3中的一个表示具有4至8个C原子的直链烷基和ω，ω-1或ω-1中的两个邻位羟基， ω-2位，另外两个基团表示在R 2和R 3的位置具有至多12个C原子的直链或支链烷基，R2的位置中具有至多4个C原子的直链或支链烷基，这两个基团中的C原子总数 通过氧化相应的链烯基黄嘌呤并通过引入二羟基烷基或其前体的化合物进行烷基化来制备最多14个的烷基取代基。 二羟基烷基二烷基黄嘌呤适用于治疗阻塞性呼吸道疾病。

    Use of xanthine derivatives for the treatment of nerve damage following an interruption in blood circulation
    9.
    发明授权
    Use of xanthine derivatives for the treatment of nerve damage following an interruption in blood circulation 失效
    黄嘌呤衍生物用于治疗血液循环中断后的神经损伤

    公开(公告)号：US5922868A

    公开(公告)日：1999-07-13

    申请号：US576936

    申请日：1995-12-22

    申请人： Werner Thorwart ,  Harald Furrer ,  Erhard Wolf ,  Ulrich Gebert ,  Erhard Rossmanith ,  John J. Grome ,  Ernst-Jurgen Schneider

    发明人： Werner Thorwart ,  Harald Furrer ,  Erhard Wolf ,  Ulrich Gebert ,  Erhard Rossmanith ,  John J. Grome ,  Ernst-Jurgen Schneider

    IPC分类号： A61K31/52 ,  A61K31/522 ,  A61P25/02 ,  A61P25/28 ,  C07D473/00 ,  C07D473/06 ,  C07D473/04 ,  C07D473/08

    CPC分类号： C07D473/06

    摘要： Use of xanthine derivatives for the treatment of nerve damage following an interruption in blood circulation.The invention relates to the use of xanthine derivatives of the formula I ##STR1## in which R.sup.2 is a (C.sub.1 -C.sub.4)-alkyl group and at least one of the symbols R.sup.1 and R.sup.3 is a radical of the formula II or III ##STR2## in which A is CHOH, CO or dioxolane, R.sup.4 is a hydrogen atom or a (C.sub.1 -C.sub.4)-alkyl group and n is 0 to 5, and in which R.sup.5 and R.sup.6 are hydrogen atoms or (C.sub.1 -C.sub.4)-alkyl groups or, together with the nitrogen atom to which they are bonded, form a 5- to 7-membered ring, it being possible for one carbon atom to be replaced by an oxygen or nitrogen atom, m is 1 or 2 and the other radical R.sup.1 or R.sup.3, if appropriate, is a hydrogen atom, a (C.sub.1 -C.sub.6)-alkyl group or a (C.sub.3 -C.sub.6)-alkenyl group, for the preparation of medicaments for the prophylaxis and treatment of nerve damage following an interruption in blood circulation, and novel xanthine derivatives, and to processes for their preparation.

    摘要翻译： 黄嘌呤衍生物用于治疗血液循环中断后的神经损伤。 本发明涉及式I的黄嘌呤衍生物，其中R2是（C1-C4） - 烷基，R1和R3中的至少一个是式II或III的基团，其中A是CHOH ，CO或二氧戊环，R4是氢原子或（C1-C4） - 烷基，n是0-5，其中R5和R6是氢原子或（C1-C4） - 烷基，或者与 与它们键合的氮原子形成5-至7-元环，一个碳原子可被氧或氮原子取代，m为1或2，另一个基团R 1或R 3如果合适 是氢原子，（C1-C6） - 烷基或（C3-C6） - 烯基，用于制备用于预防和治疗血液循环中断后的神经损伤的药物，以及新颖的黄嘌呤衍生物 ，以及其准备过程。