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1.发明授权Method for treating a mammal by administration of a compound having the ability to release CO 有权通过给予具有释放CO能力的化合物来治疗哺乳动物的方法公开(公告)号：US09023402B2
公开(公告)日：2015-05-05
申请号：US13078735
申请日：2011-04-01
IPC分类号： A61K33/00 , A61K33/24 , A61K31/28 , A61K31/665 , A61K31/67 , A61K31/675 , C07F17/00 , A61K31/00 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/616 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/14 , A61K33/32 , A61K45/06 , A61K47/48 , C07F11/00 , C07F13/00 , C07F15/02
CPC分类号： C07F17/00 , A61K31/00 , A61K31/28 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/616 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K45/06 , A61K47/52 , C07F11/005 , C07F13/005 , C07F15/02 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/879 , Y10S514/886 , Y10S514/887 , Y10S514/894 , Y10S514/903 , Y10S514/921 , Y10S514/929 , Y10S514/95 , Y10S514/958 , Y10S514/959 , Y10S514/964 , A61K2300/00
摘要： Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
摘要翻译： 几类体内释放一氧化碳的化合物可用于治疗和/或预防疾病，例如慢性炎症，例如类风湿性关节炎，以及具有强烈炎症成分的疾病，例如动脉粥样硬化，中风，冠状动脉疾病， 和阿尔茨海默病。 体内释放一氧化碳的化合物可以连接到已知的药物载体和/或已知的抗炎药物，例如阿司匹林。
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2.发明授权Method for treating a mammal by administration of a compound having the ability to release CO 有权通过给予具有释放CO能力的化合物来治疗哺乳动物的方法公开(公告)号：US07964220B2
公开(公告)日：2011-06-21
申请号：US11453319
申请日：2006-06-14
CPC分类号： C07F17/00 , A61K31/00 , A61K31/28 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/616 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K45/06 , A61K47/52 , C07F11/005 , C07F13/005 , C07F15/02 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/879 , Y10S514/886 , Y10S514/887 , Y10S514/894 , Y10S514/903 , Y10S514/921 , Y10S514/929 , Y10S514/95 , Y10S514/958 , Y10S514/959 , Y10S514/964 , A61K2300/00
摘要： Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
摘要翻译： 几类体内释放一氧化碳的化合物可用于治疗和/或预防疾病，例如慢性炎症，例如类风湿性关节炎，以及具有强烈炎症成分的疾病，例如动脉粥样硬化，中风，冠状动脉疾病， 和阿尔茨海默病。 体内释放一氧化碳的化合物可以连接到已知的药物载体和/或已知的抗炎药物，例如阿司匹林。
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公开(公告)号：US20110038955A1
公开(公告)日：2011-02-17
申请号：US12670466
申请日：2008-07-24
申请人： Sandra S. Rodrigues , Joao D. Seixas , Bruno Guerreiro , Nuno Miguel Penacho Pereira , Carlos C. Romao , Werner E. Haas , Isabel Maria de Sousa Goncalves
发明人： Sandra S. Rodrigues , Joao D. Seixas , Bruno Guerreiro , Nuno Miguel Penacho Pereira , Carlos C. Romao , Werner E. Haas , Isabel Maria de Sousa Goncalves
IPC分类号： A61K33/00 , A61K31/555 , A61P29/00 , A61P1/04
CPC分类号： A61K33/00 , A61K9/0053 , A61K9/08 , A61K31/405 , A61K31/555 , A61K45/06 , A61K47/36 , A61K47/55 , A61K2300/00
摘要： The invention relates to the use of carbon monoxide (CO) to inhibit the gastrointestinal side effects caused by non-steroidal anti-inflammatory drugs (NSAIDs) and/or alcohol.
摘要翻译： 本发明涉及使用一氧化碳（CO）抑制由非甾体抗炎药（NSAID）和/或酒精引起的胃肠道副作用。
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4.发明授权Methods for treating inflammatory disease by administering aldehydes and derivatives thereof 有权通过施用醛及其衍生物治疗炎性疾病的方法公开(公告)号：US07968605B2
公开(公告)日：2011-06-28
申请号：US11702970
申请日：2007-02-06
CPC分类号： A61K31/11 , A61K31/00 , A61K31/136 , A61K31/28 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/54 , A61K31/555 , A61K31/60 , A61K31/603 , A61K31/616 , A61K31/695 , A61K31/7048 , A61K31/7135 , A61K33/00 , A61K33/14 , A61K33/32 , A61K45/06 , A61K47/52 , C07F11/005 , C07F13/005 , C07F15/02 , C07F17/00 , A61K2300/00
摘要： A method is disclosed for treating inflammatory disease in an animal in need thereof by administering to the animal a pharmaceutical composition containing an anti-inflammatory effective amount of an organic aldehyde compound or a derivative thereof in a pharmaceutically acceptable vehicle.
摘要翻译： 公开了一种通过在药学上可接受的载体中向动物施用含有抗炎有效量的有机醛化合物或其衍生物的药物组合物来治疗有需要的动物中的炎性疾病的方法。
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公开(公告)号：US20100196516A1
公开(公告)日：2010-08-05
申请号：US12597665
申请日：2008-04-24
IPC分类号： A61K33/00 , A61K31/555 , C07F11/00 , A61P31/04 , A61P31/12 , A61P31/10 , A61P33/06 , A61P33/02
CPC分类号： A61K33/00 , A61K31/28 , A61K31/555 , Y02A50/473
摘要： The invention relates to the use of carbon monoxide (CO) to treat infections. The invention also provides novel carbon monoxide releasing molecules (CORMs).
摘要翻译： 本发明涉及一氧化碳（CO）用于治疗感染的用途。 本发明还提供新型的一氧化碳释放分子（CORM）。
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6.发明申请Compositions Comprising Organometallic Molybdenum Compounds For Treating Cancer 审中-公开包含有机金属钼化合物治疗癌症的组合物公开(公告)号：US20080311189A1
公开(公告)日：2008-12-18
申请号：US10593283
申请日：2004-03-18
申请人： Marta R.P. Norton Matos , Carlos C. Romao , Claudia Cristina Lage Pereira , Sandra S. Rodrigues , Marcia Mora , Maria Joao Pires Silva , Paula M. Alves , Celso Albuquerque Reis
发明人： Marta R.P. Norton Matos , Carlos C. Romao , Claudia Cristina Lage Pereira , Sandra S. Rodrigues , Marcia Mora , Maria Joao Pires Silva , Paula M. Alves , Celso Albuquerque Reis
CPC分类号： C07F17/00
摘要： The invention provides several molybdenum (II) complexes (see classes I and II, FIG. 1) as well as pharmaceutical compositions comprising these compounds, that are useful for treating cancer and describes synthetic methods and intermediates useful for preparing the compounds.
摘要翻译： 本发明提供了几种钼（II）配合物（见I类和II类，图1）以及包含这些化合物的药物组合物，其可用于治疗癌症并描述可用于制备化合物的合成方法和中间体。
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