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1.发明授权
公开(公告)号：US4559343A
公开(公告)日：1985-12-17
申请号：US415758
申请日：1982-09-07
申请人： Wesley W. Han , Robert E. Roehrs
发明人： Wesley W. Han , Robert E. Roehrs
IPC分类号： A61K31/195 , A61K31/19 , A61K31/38 , A61K31/405 , A61K31/505 , A61K31/52 , A61P27/02 , A61P29/00
CPC分类号： A61K31/52 , Y10S514/914 , Y10S514/974
摘要： Xanthine derivatives are described which decrease the stinging associated with the application of ophthalmic acidic anti-inflammatory agents.
摘要翻译： 描述了黄嘌呤衍生物，其减少与眼用酸性抗炎剂的应用相关的刺痛。
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公开(公告)号：US5209927A
公开(公告)日：1993-05-11
申请号：US716426
申请日：1991-06-17
CPC分类号： A61K31/78 , A61K9/0048 , Y10S514/915
摘要： Disclosed is a liquid ophthalmic composition of unique rheological and lubricating properties comprising, inter alia, a polyanionic polymer for use as a long lasting artificial tear. Also disclosed is a method of treatment comprising topically administering the composition when indicated for relief of dry eye syndrome, foreign body sensation, burning, hyperemia, corneal staining, and the like.
摘要翻译： 公开了独特的流变学和润滑性质的液体眼用组合物，其特别包括用作持久人造泪液的聚阴离子聚合物。 还公开了一种治疗方法，包括当指定用于缓解干眼综合征，异物感觉，烧灼，充血，角膜染色等时局部施用组合物。
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公开(公告)号：US4550022A
公开(公告)日：1985-10-29
申请号：US582564
申请日：1984-02-22
CPC分类号： A61K9/0048
摘要： A tissue irrigating solution useful for irrigating animal tissue, such as ocular tissue and neuro tissue, during surgery, contains sodium, potassium, magnesium, calcium, chloride, and bicarbonate ions as well as dextrose and glutathione in proportions consistant with the osmotic stability and continued metabolism of the tissue cells. The irrigating solution is prepared by mixing a first basic solution which provides the bicarbonate and a second acidic solution which provides the calcium, magnesium, dextrose and glutathione. The first and second solutions may be stored as stable, sterile solutions for extended periods of time and mixed within 24 hours of use.
摘要翻译： 在手术过程中，用于灌洗动物组织如眼组织和神经组织的组织冲洗溶液含有钠，钾，镁，钙，氯化物和碳酸氢根离子以及与渗透稳定性成比例的葡萄糖和谷胱甘肽 组织细胞的代谢。 冲洗溶液通过混合提供碳酸氢盐的第一碱性溶液和提供钙，镁，葡萄糖和谷胱甘肽的第二酸性溶液来制备。 第一溶液和第二溶液可以作为稳定的无菌溶液长时间储存，并在使用24小时内混合。
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4.发明授权
公开(公告)号：US4966773A
公开(公告)日：1990-10-30
申请号：US339915
申请日：1989-04-17
CPC分类号： A61K31/20 , A61K9/0048 , Y10S514/912 , Y10S514/915
摘要： Topical ophthalmic compositions containing microfine particles of one or more retinoids are described. The compositions are useful in the treatment of dry eye syndrome and related ophthalmic surface disorders and as ocular lubricants. A method of treating dry eye syndrome and related ophthalmic surface disorders and a method of providing topical ocular lubrication using these compositions are also described.
摘要翻译： 描述了含有一种或多种类视黄醇的微细颗粒的局部眼用组合物。 该组合物可用于治疗干眼综合征和相关的眼表疾病和眼部润滑剂。 还描述了治疗干眼综合征和相关眼表疾病的方法以及使用这些组合物提供局部眼部润滑的方法。
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公开(公告)号：US4407792A
公开(公告)日：1983-10-04
申请号：US243266
申请日：1981-03-12
CPC分类号： A61K31/765 , A61K47/30 , A61K9/0014 , A61K9/0048 , Y10S514/912
摘要： The present invention is directed to an aqueous dispersion of an ophthalmic drug and a high molecular weight polymer which forms a highly viscous gel and can be used to prolong the duration of activity of the ophthalmic drug when the gel is applied into the conjunctival sac of the eye. The ophthalmic drug-containing gel composition has prolonged retention time in the eye and remains in contact with the surface of the eye for an extended period of time.
摘要翻译： 本发明涉及眼用药物和高分子量聚合物的水性分散体，其形成高粘度凝胶，并且可以用于延长眼药物的活性持续时间，当将凝胶应用于眼药物的结膜囊中时 眼。 含眼药物的凝胶组合物在眼睛中具有延长的保留时间并且在长时间内保持与眼睛表面接触。
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公开(公告)号：US5075104A
公开(公告)日：1991-12-24
申请号：US597983
申请日：1990-10-15
IPC分类号： A61K9/00 , A61K31/765 , A61K31/78
CPC分类号： A61K31/78 , A61K31/765 , A61K9/0048 , Y10S514/912 , Y10S514/915
摘要： Disclosed is an ophthalmic gel composition of unique rheological and lubricating properties comprising, inter alia, a carboxy vinyl polymer (carbomer) for use as a long lasting artificial tear. Also disclosed is a method of treatment comprising totally administering the composition when indicated for relief of dry eye syndrom, foreign body sensation, burning, hyperemia, corneal straining, and the like.
摘要翻译： 公开了独特的流变学和润滑性质的眼用凝胶组合物，其特别包括用作持久人造泪液的羧乙烯基聚合物（卡波姆）。 还公开了一种治疗方法，包括当指定用于缓解干眼综合征，异物感觉，烧灼，充血，角膜应变等时完全施用该组合物。
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公开(公告)号：US4826871A
公开(公告)日：1989-05-02
申请号：US935477
申请日：1986-11-26
CPC分类号： A61K31/045 , A61K31/07 , A61K31/11 , A61K31/34 , A61K31/38 , A61K9/0048 , Y10S514/915
摘要： Topical ophthalmic compositions containing one or more retinoids selected from the group consisting of near and remote analogues and derivatives of retinoic acid are described. Six classes of ophthalmic vehicles suitable as carriers for the retinoids are also described. The compositions are useful in the treatment of dry eye syndrome and related ophthalmic surface disorders and as ocular lubricants. A method of treating dry eye syndrome and related ophthalmic surface disorders and a method of providing topical ocular lubrication using these compositions are also described.
摘要翻译： 描述了含有一种或多种类视黄醇的局部眼用组合物，其选自近视和远程类似物和视黄酸衍生物。 还描述了适合作为类视色素的载体的六类眼科车辆。 该组合物可用于治疗干眼综合征和相关的眼表疾病和眼部润滑剂。 还描述了治疗干眼综合征和相关眼表疾病的方法以及使用这些组合物提供局部眼部润滑的方法。
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公开(公告)号：US4443432A
公开(公告)日：1984-04-17
申请号：US308386
申请日：1981-10-05
CPC分类号： A61K9/0048
摘要： An ophthalmic irrigating solution useful for irrigating the human eye contains sodium, potassium, magnesium, calcium, chloride, and bicarbonate ions as well as dextrose and glutathione in proportions consistent with the osmotic stability and continued metabolism of the endothelial cells. The irrigating solution is prepared by mixing a first basic solution which provides the bicarbonate and a second acidic solution which provides the calcium, magnesium, dextrose and glutathione. The first and second solutions may be stored as stable, sterile solutions for extended periods of time and mixed within 24 hours of use.
摘要翻译： 用于冲洗人眼的眼用冲洗液含有钠，钾，镁，钙，氯和碳酸氢根离子以及右旋糖和谷胱甘肽，其比例与内皮细胞的渗透稳定性和持续代谢相一致。 冲洗溶液通过混合提供碳酸氢盐的第一碱性溶液和提供钙，镁，葡萄糖和谷胱甘肽的第二酸性溶液来制备。 第一溶液和第二溶液可以作为稳定的无菌溶液长时间储存，并在使用24小时内混合。
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公开(公告)号：US4271143A
公开(公告)日：1981-06-02
申请号：US37314
申请日：1979-05-09
CPC分类号： A61K9/0048
摘要： The present invention is directed to an aqueous dispersion of an ophthalmic drug and a high molecular weight polymer which forms a highly viscous gel and can be used to prolong the duration of activity of the ophthalmic drug when the gel is applied into the conjunctival sac of the eye. The ophthalmic drug-containing gel composition has prolonged retention time in the eye and remains in contact with the surface of the eye for an extended period of time.
摘要翻译： 本发明涉及眼用药物和高分子量聚合物的水性分散体，其形成高粘度凝胶，并且可以用于延长眼药物的活性持续时间，当将凝胶应用于眼药物的结膜囊中时 眼。 含眼药物的凝胶组合物在眼睛中具有延长的保留时间并且在长时间内保持与眼睛表面接触。
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