公开(公告)号：US08934261B2

公开(公告)日：2015-01-13

申请号：US12489429

申请日：2009-06-23

申请人： Wey-Jiun Lin ,  Kevin Pan ,  Conrado Sacluti de la Cruz

发明人： Wey-Jiun Lin ,  Kevin Pan ,  Conrado Sacluti de la Cruz

IPC分类号： H05K1/11 ,  H05K1/14 ,  H01R13/11 ,  H01R12/00 ,  H01R13/66 ,  H01R12/57 ,  H05K3/36

CPC分类号： H01R13/111 ,  H01R9/091 ,  H01R12/57 ,  H01R12/58 ,  H01R13/6675 ,  H05K1/141 ,  H05K1/145 ,  H05K3/366 ,  H05K2201/048 ,  H05K2201/09181 ,  H05K2201/10189 ,  Y10T29/49002 ,  Y10T29/49117

摘要： High density electronic device assemblies and techniques for forming high density electronic device assemblies are disclosed. These assemblies and techniques can be used to form compact electronic devices. In one embodiment, substrate arrangements that include a multiple-part substrate can be used to form a high density electronic device assembly. In another embodiment, one or more clips can be used in a high density electronic device assembly to provide mechanical and electrical interconnection between electrical structures that are to be removably coupled together as parts of the high density electronic device assembly. In still another embodiment, a removable cap (and a method for forming the removable cap) can be used for an electronic device housing.

摘要翻译： 公开了用于形成高密度电子器件组件的高密度电子器件组件和技术。 这些组件和技术可用于形成紧凑的电子设备。 在一个实施例中，包括多部分衬底的衬底布置可用于形成高密度电子器件组件。 在另一个实施例中，一个或多个夹子可用于高密度电子器件组件中，以提供电气结构之间的机械和电气互连，电气结构可以作为高密度电子器件组件的部件可拆卸地耦合在一起。 在另一个实施例中，可拆卸盖（以及用于形成可拆卸盖的方法）可用于电子设备外壳。

公开(公告)号：US20100159755A1

公开(公告)日：2010-06-24

申请号：US12489429

申请日：2009-06-23

申请人： Wey-Jiun Lin ,  Kevin Pan ,  CONRADO SACLUTI DE LA CRUZ

发明人： Wey-Jiun Lin ,  Kevin Pan ,  CONRADO SACLUTI DE LA CRUZ

IPC分类号： H01R4/48 ,  H05K1/11 ,  H05K5/00 ,  H01S4/00 ,  H05K7/00

CPC分类号： H01R13/111 ,  H01R9/091 ,  H01R12/57 ,  H01R12/58 ,  H01R13/6675 ,  H05K1/141 ,  H05K1/145 ,  H05K3/366 ,  H05K2201/048 ,  H05K2201/09181 ,  H05K2201/10189 ,  Y10T29/49002 ,  Y10T29/49117

摘要： High density electronic device assemblies and techniques for forming high density electronic device assemblies are disclosed. These assemblies and techniques can be used to form compact electronic devices. In one embodiment, substrate arrangements that include a multiple-part substrate can be used to form a high density electronic device assembly. In another embodiment, one or more clips can be used in a high density electronic device assembly to provide mechanical and electrical interconnection between electrical structures that are to be removably coupled together as parts of the high density electronic device assembly. In still another embodiment, a removable cap (and a method for forming the removable cap) can be used for an electronic device housing.

摘要翻译： 公开了用于形成高密度电子器件组件的高密度电子器件组件和技术。 这些组件和技术可用于形成紧凑的电子设备。 在一个实施例中，包括多部分衬底的衬底布置可用于形成高密度电子器件组件。 在另一个实施例中，一个或多个夹子可用于高密度电子器件组件中，以提供电气结构之间的机械和电气互连，电气结构可以作为高密度电子器件组件的部件可拆卸地耦合在一起。 在另一个实施例中，可拆卸盖（以及用于形成可拆卸盖的方法）可用于电子设备外壳。

公开(公告)号：US20120155041A1

公开(公告)日：2012-06-21

申请号：US13407625

申请日：2012-02-28

申请人： Wey-Jiun Lin ,  Kevin Pan ,  Conrado Sacluti de la Cruz

发明人： Wey-Jiun Lin ,  Kevin Pan ,  Conrado Sacluti de la Cruz

IPC分类号： H05K5/00 ,  H05K13/04

CPC分类号： H01R13/111 ,  H01R12/00 ,  H01R12/57 ,  H01R12/58 ,  H01R13/6675 ,  H05K1/141 ,  H05K1/145 ,  H05K3/366 ,  H05K2201/048 ,  H05K2201/09181 ,  H05K2201/10189 ,  Y10T29/49002 ,  Y10T29/49117

摘要： High density electronic device assemblies and techniques for forming high density electronic device assemblies are disclosed. These assemblies and techniques can be used to form compact electronic devices, such as portable power adapters. In one embodiment, substrate arrangements that include a multiple-part substrate can be used to form a high density electronic device assembly. In another embodiment, one or more clips can be used in a high density electronic device assembly to provide mechanical and electrical interconnection between electrical structures that are to be removably coupled together as parts of the high density electronic device assembly. In still another embodiment, a removable cap (and a method for forming the removable cap) can be used for an electronic device housing.

摘要翻译： 公开了用于形成高密度电子器件组件的高密度电子器件组件和技术。 这些组件和技术可用于形成诸如便携式电源适配器之类的紧凑型电子设备。 在一个实施例中，包括多部分衬底的衬底布置可用于形成高密度电子器件组件。 在另一个实施例中，一个或多个夹子可用于高密度电子器件组件中，以提供电气结构之间的机械和电气互连，电气结构可以作为高密度电子器件组件的部件可拆卸地耦合在一起。 在另一个实施例中，可拆卸盖（以及用于形成可拆卸盖的方法）可用于电子设备外壳。

公开(公告)号：US20060128772A1

公开(公告)日：2006-06-15

申请号：US11344772

申请日：2006-02-01

申请人： Magdalena Eisinger ,  Louis Fitzpatrick ,  Daniel Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen Reitz ,  Virginia Smith-Swintosky ,  Boyu Zhao

发明人： Magdalena Eisinger ,  Louis Fitzpatrick ,  Daniel Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen Reitz ,  Virginia Smith-Swintosky ,  Boyu Zhao

IPC分类号： A61K31/433 ,  C07D285/08

CPC分类号： C07D285/08 ,  A61K8/49 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/007 ,  C07D417/12

摘要： The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.

公开(公告)号：US06777421B2

公开(公告)日：2004-08-17

申请号：US10117674

申请日：2002-04-05

申请人： Alfonzo Jordan ,  Allen B. Reitz ,  Kevin Pan

发明人： Alfonzo Jordan ,  Allen B. Reitz ,  Kevin Pan

IPC分类号： A61K314353

CPC分类号： C07D471/10

摘要： The present invention is directed to novel 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, substance abuse, neuropathic pain, acute pain, migraine, asthma, cough and for improved cognition.

摘要翻译： 本发明涉及一般形式的新的1,3,8-三氮杂螺[4.5]癸-4-酮衍生物，所有变量如本文所定义，可用于治疗由ORL-1 G- 蛋白偶联受体。 更具体地，本发明的化合物可用于治疗诸如焦虑，抑郁，药物滥用，神经性疼痛，急性疼痛，偏头痛，哮喘，咳嗽和改善认知的病症和病症。

公开(公告)号：US08501791B2

公开(公告)日：2013-08-06

申请号：US12835220

申请日：2010-07-13

申请人： Magdalena Eisinger ,  Louis J. Fitzpatrick ,  Daniel H. Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen B. Reitz ,  Virginia L. Smith-Swintosky ,  Boyu Zhao

发明人： Magdalena Eisinger ,  Louis J. Fitzpatrick ,  Daniel H. Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen B. Reitz ,  Virginia L. Smith-Swintosky ,  Boyu Zhao

IPC分类号： A61K31/433 ,  C07D285/08

CPC分类号： C07D285/08 ,  A61K8/49 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/007 ,  C07D333/16 ,  C07D417/12 ,  C07F9/4018

摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.

摘要翻译： 本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。 更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经 伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑， 眼红斑痤疮和外分泌腺疾病。

公开(公告)号：US20100280079A1

公开(公告)日：2010-11-04

申请号：US12835220

申请日：2010-07-13

申请人： Magdalena Eisinger ,  Louis J. Fitzpatrick ,  Daniel H. Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen B. Reitz ,  Virginia L. Smith-Swintosky ,  Boyu Zhao

发明人： Magdalena Eisinger ,  Louis J. Fitzpatrick ,  Daniel H. Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen B. Reitz ,  Virginia L. Smith-Swintosky ,  Boyu Zhao

IPC分类号： A61K31/433 ,  A61K31/4439 ,  A61P25/00 ,  A61P17/00 ,  A61P3/00 ,  A61P15/00

CPC分类号： C07D285/08 ,  A61K8/49 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/007 ,  C07D333/16 ,  C07D417/12 ,  C07F9/4018

摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.

摘要翻译： 本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。 更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经 伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑， 眼红斑痤疮和外分泌腺疾病。

公开(公告)号：US07319107B2

公开(公告)日：2008-01-15

申请号：US10287096

申请日：2002-11-04

申请人： Magdalena Eisinger ,  Louis J. Fitzpatrick ,  Daniel H. Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen B. Reitz ,  Virginia L. Smith-Swintosky ,  Boyu Zhao

发明人： Magdalena Eisinger ,  Louis J. Fitzpatrick ,  Daniel H. Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen B. Reitz ,  Virginia L. Smith-Swintosky ,  Boyu Zhao

IPC分类号： A61K31/433 ,  C07D285/08

CPC分类号： C07D285/08 ,  A61K8/49 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/007 ,  C07D333/16 ,  C07D417/12 ,  C07F9/4018

摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.

摘要翻译： 本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑-2-基衍生物。 更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经 伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑， 眼红斑痤疮和外分泌腺疾病。

公开(公告)号：US07049331B2

公开(公告)日：2006-05-23

申请号：US10287095

申请日：2002-11-04

申请人： Magdalena Eisinger ,  Louis J. Fitzpatrick ,  Daniel H. Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen B. Reitz ,  Virginia L. Smith-Swintosky ,  Boyu Zhao

发明人： Magdalena Eisinger ,  Louis J. Fitzpatrick ,  Daniel H. Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen B. Reitz ,  Virginia L. Smith-Swintosky ,  Boyu Zhao

IPC分类号： A61K31/433 ,  C07D285/08

CPC分类号： C07D285/08 ,  A61K8/49 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/007 ,  C07D417/12

摘要： The present invention is directed to novel 1,2,4-thiadiazole derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.

摘要翻译： 本发明涉及可用作黑皮质素受体的激动剂或拮抗剂的新颖的1,2,4-噻二唑衍生物。 更具体地，本发明的化合物可用于治疗代谢，CNS和皮肤病学障碍，例如肥胖症，口服葡萄糖耐量降低，血糖水平升高，II型糖尿病，X综合征，糖尿病性视网膜病变，脊髓损伤，神经 伤口，急性神经退行性疾病，慢性神经退行性疾病，性欲症，男性勃起功能障碍，干眼症，痤疮，干性皮肤，老年皮肤，脂溢性皮炎，酒渣鼻，过度耳垢，睑板腺疾病，假性结石炎，酵母菌感染，头皮屑， 眼红斑痤疮和外分泌腺疾病。

公开(公告)号：US20060030604A1

公开(公告)日：2006-02-09

申请号：US11236097

申请日：2005-09-27

申请人： Magdalena Elsinger ,  Louis Fitzpatrick ,  Daniel Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen Reitz ,  Virginia Smith-Swintosky ,  Boyu Zhao

发明人： Magdalena Elsinger ,  Louis Fitzpatrick ,  Daniel Lee ,  Kevin Pan ,  Carlos Plata-Salaman ,  Allen Reitz ,  Virginia Smith-Swintosky ,  Boyu Zhao

IPC分类号： C07D285/08 ,  A61K31/433

CPC分类号： C07D285/08 ,  A61K8/49 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/007 ,  C07D333/16 ,  C07D417/12 ,  C07F9/4018

摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.