公开(公告)号：US10093904B2

公开(公告)日：2018-10-09

申请号：US15607028

申请日：2017-05-26

Applicant: Whitehead Institute for Biomedical Research

Inventor： Rudolf Jaenisch ,  Yaqub Hanna ,  Marius Wernig ,  Christopher J. Lengner ,  Alexander Meissner ,  Oliver Tobias Brambrink ,  G. Grant Welstead ,  Ruth Foreman

IPC: C12N5/00 ,  C12N5/074 ,  C07K14/47 ,  A01K67/027 ,  G01N33/50 ,  C12N15/877 ,  C12N15/85

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

公开(公告)号：US09714414B2

公开(公告)日：2017-07-25

申请号：US14473250

申请日：2014-08-29

Applicant: Whitehead Institute for Biomedical Research

Inventor： Rudolf Jaenisch ,  Yaqub Hanna ,  Marius Wernig ,  Christopher J. Lengner ,  Alexander Meissner ,  Oliver Tobias Brambrink ,  G. Grant Welstead ,  Ruth Foreman

IPC: C12N5/074 ,  C07K14/47 ,  A01K67/027 ,  C12N15/85 ,  C12N15/877 ,  G01N33/50

CPC classification number: C12N5/0696 ,  A01K67/0273 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  C07K14/4702 ,  C12N15/8509 ,  C12N15/8775 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2506/11 ,  C12N2506/13 ,  C12N2800/30 ,  C12N2830/003 ,  C12N2830/006 ,  G01N33/5023 ,  G01N2333/91011

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

公开(公告)号：US20150118755A1

公开(公告)日：2015-04-30

申请号：US14473250

申请日：2014-08-29

Applicant: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH

Inventor： Rudolf Jaenisch ,  Yaqub Hanna ,  Marius Wernig ,  Christopher J. Lengner ,  Alexander Meissner ,  Oliver Tobias Brambrink ,  G. Grant Welstead ,  Ruth Foreman

IPC: C12N5/074

CPC classification number: C12N5/0696 ,  A01K67/0273 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  C07K14/4702 ,  C12N15/8509 ,  C12N15/8775 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2506/11 ,  C12N2506/13 ,  C12N2800/30 ,  C12N2830/003 ,  C12N2830/006 ,  G01N33/5023 ,  G01N2333/91011

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

Abstract translation: 本公开涉及将一种或多种体细胞（例如部分分化或完全/终末分化的体细胞）重新编程为较少分化状态（例如多能或多能状态）的方法。 在另外的实施方案中，本发明还涉及通过本发明的方法产生的重编程体细胞，所述细胞的用途以及用于鉴定用于重编程体细胞的药剂的方法。

公开(公告)号：US20170342386A1

公开(公告)日：2017-11-30

申请号：US15607028

申请日：2017-05-26

Applicant: Whitehead Institute for Biomedical Research

Inventor： Rudolf Jaenisch ,  Yaqub Hanna ,  Marius Wernig ,  Christopher J. Lengner ,  Alexander Meissner ,  Oliver Tobias Brambrink ,  G. Grant Welstead ,  Ruth Foreman

IPC: C12N5/074 ,  C07K14/47 ,  G01N33/50 ,  C12N15/877 ,  C12N15/85 ,  A01K67/027

CPC classification number: C12N5/0696 ,  A01K67/0273 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  C07K14/4702 ,  C12N15/8509 ,  C12N15/8775 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2506/11 ,  C12N2506/13 ,  C12N2800/30 ,  C12N2830/003 ,  C12N2830/006 ,  G01N33/5023 ,  G01N2333/91011

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

公开(公告)号：US20190241874A1

公开(公告)日：2019-08-08

申请号：US16147003

申请日：2018-09-28

Applicant: Whitehead Institute for Biomedical Research

Inventor： Rudolf Jaenisch ,  Yaqub Hanna ,  Marius Wernig ,  Christopher J. Lengner ,  Alexander Meissner ,  Oliver Tobias Brambrink ,  G. Grant Welstead ,  Ruth Foreman

IPC: C12N5/074 ,  C07K14/47

CPC classification number: C12N5/0696 ,  A01K67/0273 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  C07K14/4702 ,  C12N15/8509 ,  C12N15/8775 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2506/11 ,  C12N2506/13 ,  C12N2800/30 ,  C12N2830/003 ,  C12N2830/006 ,  G01N33/5023 ,  G01N2333/91011

Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.