公开(公告)号：US12215361B2

公开(公告)日：2025-02-04

申请号：US18444590

申请日：2024-02-16

Applicant: Whitehead Institute for Biomedical Research

Inventor： Edwin Neumann ,  Tessa Bertozzi ,  Jonathan Weissman

IPC: C12N9/10 ,  A61K38/46 ,  C12N9/22 ,  C12N15/86

Abstract: The disclosure provides, in various embodiments, fusion proteins comprising a DNA-binding domain, a DNMT3A-binding domain, and a H3K4me0; and polynucleotides and vectors encoding one or more of the fusion proteins. The disclosure also provides, in various embodiments, gene-delivery systems, cells, compositions (e.g., pharmaceutical compositions) and kits comprising one or more of the fusion proteins polynucleotides, or vectors; methods of epigenetically modifying a genomic locus in a cell; and methods of treating a subject (e.g., a human) in need thereof.

公开(公告)号：US20250027059A1

公开(公告)日：2025-01-23

申请号：US18894575

申请日：2024-09-24

Applicant: Whitehead Institute for Biomedical Research

Inventor： Edwin Neumann ,  Tessa Bertozzi ,  Jonathan Weissman

IPC: C12N9/10 ,  A61K38/46 ,  C12N9/22 ,  C12N15/86

Abstract: The disclosure provides, in various embodiments, fusion proteins comprising a DNA-binding domain, a DNMT3A-binding domain, and a H3K4me0; and polynucleotides and vectors encoding one or more of the fusion proteins. The disclosure also provides, in various embodiments, gene-delivery systems, cells, compositions (e.g., pharmaceutical compositions) and kits comprising one or more of the fusion proteins polynucleotides, or vectors; methods of epigenetically modifying a genomic locus in a cell; and methods of treating a subject (e.g., a human) in need thereof.

公开(公告)号：US12252715B2

公开(公告)日：2025-03-18

申请号：US18444590

申请日：2024-02-16

Applicant: Whitehead Institute for Biomedical Research

Inventor： Edwin Neumann ,  Tessa Bertozzi ,  Jonathan Weissman

IPC: C12N9/10 ,  A61K38/46 ,  C12N9/22 ,  C12N15/86

Abstract: The disclosure provides, in various embodiments, fusion proteins comprising a DNA-binding domain, a DNMT3A-binding domain, and a H3K4me0; and polynucleotides and vectors encoding one or more of the fusion proteins. The disclosure also provides, in various embodiments, gene-delivery systems, cells, compositions (e.g., pharmaceutical compositions) and kits comprising one or more of the fusion proteins polynucleotides, or vectors; methods of epigenetically modifying a genomic locus in a cell; and methods of treating a subject (e.g., a human) in need thereof.

公开(公告)号：US20250019673A1

公开(公告)日：2025-01-16

申请号：US18894709

申请日：2024-09-24

Applicant: Whitehead Institute for Biomedical Research

Inventor： Edwin Neumann ,  Tessa Bertozzi ,  Jonathan Weissman

IPC: C12N9/10 ,  A61K38/46 ,  C12N9/22 ,  C12N15/86

Abstract: The disclosure provides, in various embodiments, fusion proteins comprising a DNA-binding domain, a DNMT3A-binding domain, and a H3K4me0; and polynucleotides and vectors encoding one or more of the fusion proteins. The disclosure also provides, in various embodiments, gene-delivery systems, cells, compositions (e.g., pharmaceutical compositions) and kits comprising one or more of the fusion proteins polynucleotides, or vectors; methods of epigenetically modifying a genomic locus in a cell; and methods of treating a subject (e.g., a human) in need thereof.

公开(公告)号：US20240279623A1

公开(公告)日：2024-08-22

申请号：US18444590

申请日：2024-02-16

Applicant: Whitehead Institute for Biomedical Research

Inventor： Edwin Neumann ,  Tessa Bertozzi ,  Jonathan Weissman

IPC: C12N9/10 ,  A61K38/46 ,  C12N9/22 ,  C12N15/86

CPC classification number: C12N9/1007 ,  A61K38/465 ,  C12N9/22 ,  C12N15/86 ,  C12Y201/01037 ,  C07K2319/80 ,  C12N2750/14143

Abstract: The disclosure provides, in various embodiments, fusion proteins comprising a DNA-binding domain, a DNMT3A-binding domain, and a H3K4me0; and polynucleotides and vectors encoding one or more of the fusion proteins. The disclosure also provides, in various embodiments, gene-delivery systems, cells, compositions (e.g., pharmaceutical compositions) and kits comprising one or more of the fusion proteins polynucleotides, or vectors; methods of epigenetically modifying a genomic locus in a cell; and methods of treating a subject (e.g., a human) in need thereof.