公开(公告)号：US12060588B2

公开(公告)日：2024-08-13

申请号：US17858758

申请日：2022-07-06

Applicant: Whitehead Institute for Biomedical Research

Inventor： Rudolf Jaenisch ,  X. Shawn Liu ,  Hao Wu

IPC: C12N9/22 ,  A61K35/30 ,  A61K35/33 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C12N9/10 ,  C12N15/11 ,  C12N15/86 ,  C12N15/90

CPC classification number: C12N9/22 ,  A61K35/30 ,  A61K35/33 ,  C12N9/1007 ,  C12N15/11 ,  C12N15/86 ,  C12N15/907 ,  C12Y201/01037 ,  C12N2310/20 ,  C12N2740/15031 ,  C12N2800/80

Abstract: The invention relates to methods of modifying DNA methylation by contacting a cell with a catalytically inactive site specific nuclease fused to an effector domain having methylation or demethylation activity and one or more guide sequences.

公开(公告)号：US20230096554A1

公开(公告)日：2023-03-30

申请号：US17858758

申请日：2022-07-06

Applicant: Whitehead Institute for Biomedical Research

Inventor： Rudolf Jaenisch ,  X. Shawn Liu ,  Hao Wu

IPC: C12N9/22 ,  A61K35/30 ,  A61K35/33 ,  C12N9/10 ,  C12N15/11 ,  C12N15/86 ,  C12N15/90

Abstract: The invention relates to methods of modifying DNA methylation by contacting a cell with a catalytically inactive site specific nuclease fused to an effector domain having methylation or demethylation activity and one or more guide sequences.

公开(公告)号：US20250011744A1

公开(公告)日：2025-01-09

申请号：US18773428

申请日：2024-07-15

Applicant: Whitehead Institute for Biomedical Research

Inventor： Rudolf Jaenisch ,  X. Shawn Liu ,  Hao Wu

IPC: C12N9/22 ,  A61K35/30 ,  A61K35/33 ,  C12N9/10 ,  C12N15/11 ,  C12N15/86 ,  C12N15/90

Abstract: The invention relates to methods of modifying DNA methylation by contacting a cell with a catalytically inactive site specific nuclease fused to an effector domain having methylation or demethylation activity and one or more guide sequences.