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    Method for loading nanoporous layers with therapeutic agent
    1.
    发明授权
    Method for loading nanoporous layers with therapeutic agent 有权
    用治疗剂负载纳米多孔层的方法

    公开(公告)号：US07713573B2

    公开(公告)日：2010-05-11

    申请号：US11352436

    申请日：2006-02-10

    申请人： Gary K. Owens ,  Brian R. Wamhoff ,  Matthew S. Hudson ,  Whye-Kei Lye ,  Joshua Spradlin ,  Michael Reed ,  Kareen Looi

    发明人： Gary K. Owens ,  Brian R. Wamhoff ,  Matthew S. Hudson ,  Whye-Kei Lye ,  Joshua Spradlin ,  Michael Reed ,  Kareen Looi

    IPC分类号： A61L33/00

    CPC分类号： A61L31/022 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/606 ,  A61L2400/12 ,  A61N1/05

    摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

    摘要翻译： 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。 在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

    Expandable body having deployable microstructures and related methods
    3.
    发明申请
    Expandable body having deployable microstructures and related methods 有权
    具有可展开微结构和相关方法的可膨胀体

    公开(公告)号：US20060122684A1

    公开(公告)日：2006-06-08

    申请号：US10521078

    申请日：2003-07-11

    申请人： Whye-Kei Lye ,  Michael Reed ,  Kareen Looi

    发明人： Whye-Kei Lye ,  Michael Reed ,  Kareen Looi

    IPC分类号： A61F2/90

    CPC分类号： A61F2/91 ,  A61F2/07 ,  A61F2/848 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91575 ,  A61F2220/0016 ,  A61F2230/0013

    摘要： Apparatuses, systems and methods for treating a patient by positioning an expandable body (10) having one or more microstructures (14) within a body lumen and penetrating the lumen wall with the microstructures (14). The microstructures are formed in or attached to the lumen through a cacheter or other suitable device. Each microstructure (14) has an end (16) which is attached to the expandable body and a free end (18). Once the apparatus is positioned within the body lumen in a desired location one or more of the microstructures are deployed wherein the free ends project radially outwardly. The free ends of the deployed microstructures penetrate the lumen wall by continued expansion of the body. Additionally, a therapeutic agent may be delivered to the lumen wall by the penetrated microstructures.

    摘要翻译： 用于通过将具有一个或多个微结构（14）的可扩张体（10）定位在体腔内并用微结构（14）穿透管腔壁来治疗患者的装置，系统和方法。 微结构通过缓冲剂或其它合适的装置形成或连接到内腔。 每个微结构（14）具有连接到可膨胀体的端部（16）和自由端（18）。 一旦将装置定位在所需位置的体腔内，则展开一个或多个微结构，其中自由端径向向外突出。 部署的微结构的自由端通过身体的持续膨胀而穿透管腔壁。 此外，治疗剂可以通过穿透的微结构递送到管腔壁。

    NANOPOROUS STENTS WITH ENHANCED CELLULAR ADHESION AND REDUCED NEOINTIMAL FORMATION
    6.
    发明申请
    NANOPOROUS STENTS WITH ENHANCED CELLULAR ADHESION AND REDUCED NEOINTIMAL FORMATION 有权
    具有增强细胞粘附和减少的近端形成的纳米棒

    公开(公告)号：US20080086198A1

    公开(公告)日：2008-04-10

    申请号：US11753134

    申请日：2007-05-24

    申请人： Gary Owens ,  Whye-Kei Lye ,  Michael Reed ,  Joshua Spradlin ,  Brian Wamhoff ,  Matthew Hudson ,  Kareen Looi

    发明人： Gary Owens ,  Whye-Kei Lye ,  Michael Reed ,  Joshua Spradlin ,  Brian Wamhoff ,  Matthew Hudson ,  Kareen Looi

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/82 ,  A61F2240/001 ,  A61F2250/0058

    摘要： The present invention relates generally to medical devices containing nanoporous surfaces and methods for making same. More specifically, the invention relates to implantable vascular stents or other biomedical devices having at least one nanoporous layer that promotes improved cellular adhesion properties that promote healing and long term biocompatibility. In the case of stents, the nanoporous layer promotes re-endothelialization at sites of stent implantation vasculature, improves overall healing, and reduces inflammation and intimal disease progression. The nanoporous layer may be optionally loaded with one or more therapeutic agent to further improve the function of the implanted stent and further augment clinical efficacy.

    摘要翻译： 本发明一般涉及含有纳米多孔表面的医疗装置及其制造方法。 更具体地，本发明涉及可植入的血管支架或其它具有至少一个纳米多孔层的生物医学装置，其促进改善的细胞粘附性质以促进愈合和长期生物相容性。 在支架的情况下，纳米多孔层促进支架植入脉管系统位点的再内皮化，改善整体愈合，并减少炎症和内膜疾病进展。 纳米多孔层可以任选地加载一种或多种治疗剂，以进一步改善植入的支架的功能并进一步增加临床疗效。

    Stent with nanoporous surface
    7.
    发明申请
    Stent with nanoporous surface 审中-公开
    支架纳米孔表面

    公开(公告)号：US20060271169A1

    公开(公告)日：2006-11-30

    申请号：US11432281

    申请日：2006-05-11

    申请人： Whye-Kei Lye ,  Kareen Looi ,  Michael Reed

    发明人： Whye-Kei Lye ,  Kareen Looi ,  Michael Reed

    IPC分类号： A61F2/82 ,  A61F2/28

    CPC分类号： A61L31/146 ,  A61F2/86 ,  A61L31/082 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  Y10S623/901 ,  Y10T428/12458

    摘要： Methods for fabricating a medical device having at least one porous layer include providing a medical device having at least one alloy and removing at least one component of the alloy to form the porous layer. Although methods may be used to make stent devices with porous layers, any other suitable medical device may be made having one or more porous layers. An alloy may include any suitable combination of metals and sometimes a combination of metal and non-metal. In some embodiments, one or more of the most electrochemically active component(s) of an alloy are removed by the dissolving (or “dealloying”) process, to leave a porous matrix behind. The porous matrix layer may then be infused with one or more therapeutic agents for enhancing treatment of a patient.

    摘要翻译： 制造具有至少一个多孔层的医疗装置的方法包括提供具有至少一种合金的医疗装置，并除去合金的至少一种成分以形成多孔层。 虽然可以使用方法来制备具有多孔层的支架装置，但是可以制造具有一个或多个多孔层的任何其它合适的医疗装置。 合金可以包括任何合适的金属组合，有时是金属和非金属的组合。 在一些实施方案中，通过溶解（或“脱模”）方法除去合金中最大的电化学活性组分中的一种或多种，​​以留下多孔基体。 然后可以用一种或多种用于增强患者治疗的治疗剂注入多孔基质层。

    Method for loading nanoporous layers with therapeutic agent
    8.
    发明申请
    Method for loading nanoporous layers with therapeutic agent 有权
    用治疗剂负载纳米多孔层的方法

    公开(公告)号：US20060193890A1

    公开(公告)日：2006-08-31

    申请号：US11352436

    申请日：2006-02-10

    申请人： Gary Owens ,  Brian Wamhoff ,  Matthew Hudson ,  Whye-Kei Lye ,  Joshua Spradlin ,  Michael Reed ,  Kareen Looi

    发明人： Gary Owens ,  Brian Wamhoff ,  Matthew Hudson ,  Whye-Kei Lye ,  Joshua Spradlin ,  Michael Reed ,  Kareen Looi

    IPC分类号： A61K6/083 ,  B05D3/02

    CPC分类号： A61L31/022 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/606 ,  A61L2400/12 ,  A61N1/05

    摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

    摘要翻译： 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。 在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

    Method for loading nanoporous layers with therapeutic agent
    9.
    发明授权
    Method for loading nanoporous layers with therapeutic agent 有权
    用治疗剂负载纳米多孔层的方法

    公开(公告)号：US08124166B2

    公开(公告)日：2012-02-28

    申请号：US12660282

    申请日：2010-02-23

    申请人： Gary Owens ,  Brian Wamhoff ,  Matthew S. Hudson ,  Whye-Kei Lye ,  Joshua Spradlin ,  Michael Reed ,  Kareen Looi

    发明人： Gary Owens ,  Brian Wamhoff ,  Matthew S. Hudson ,  Whye-Kei Lye ,  Joshua Spradlin ,  Michael Reed ,  Kareen Looi

    IPC分类号： A61L33/00

    CPC分类号： A61L31/022 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/606 ,  A61L2400/12 ,  A61N1/05

    摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

    摘要翻译： 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。 在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

    Nanoporous stents with improved radiolucency
    10.
    发明申请
    Nanoporous stents with improved radiolucency 审中-公开
    具有改善放射性的纳米多支架

    公开(公告)号：US20060276885A1

    公开(公告)日：2006-12-07

    申请号：US11431941

    申请日：2006-05-10

    申请人： Whye-Kei Lye ,  Gary Owens ,  Michael Reed ,  Brian Wamhoff ,  Kareen Looi ,  Joshua Spradlin

    发明人： Whye-Kei Lye ,  Gary Owens ,  Michael Reed ,  Brian Wamhoff ,  Kareen Looi ,  Joshua Spradlin

    IPC分类号： A61F2/02 ,  A61F2/82

    CPC分类号： A61L31/022 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/606 ,  A61L2400/12 ,  A61N1/05

    摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

    摘要翻译： 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。 在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。