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    Method for loading nanoporous layers with therapeutic agent
    1.
    发明授权
    Method for loading nanoporous layers with therapeutic agent 有权
    用治疗剂负载纳米多孔层的方法

    公开(公告)号：US07713573B2

    公开(公告)日：2010-05-11

    申请号：US11352436

    申请日：2006-02-10

    申请人： Gary K. Owens ,  Brian R. Wamhoff ,  Matthew S. Hudson ,  Whye-Kei Lye ,  Joshua Spradlin ,  Michael Reed ,  Kareen Looi

    发明人： Gary K. Owens ,  Brian R. Wamhoff ,  Matthew S. Hudson ,  Whye-Kei Lye ,  Joshua Spradlin ,  Michael Reed ,  Kareen Looi

    IPC分类号： A61L33/00

    CPC分类号： A61L31/022 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/606 ,  A61L2400/12 ,  A61N1/05

    摘要： The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices having at least one porous layer, and methods for making such devices, and loading such devices with therapeutic agents. A mixture or alloy is placed on the surface of a medical device, then one component of the mixture or alloy is generally removed without generally removing the other components of the mixture or alloy. In some embodiments, a porous layer is adapted for bonding non-metallic coating, including drug eluting polymeric coatings. A porous layer may have a random pore structure or an oriented or directional grain porous structure. One embodiment of the invention relates to medical devices, including vascular stents, having at least one porous layer adapted to resist stenosis or cellular proliferation without requiring elution of therapeutic agents. The invention also includes methods, devices, and specifications for loading of drugs and other therapeutic agents into nanoporous coatings.

    摘要翻译： 本发明一般涉及具有治疗洗脱组分的医疗装置及其制备方法。 更具体地，本发明涉及具有至少一个多孔层的可植入医疗装置，以及用于制造这种装置的方法，以及用治疗剂加载这些装置。 将混合物或合金放置在医疗装置的表面上，然后通常除去混合物或合金的一种组分，而不会通常除去混合物或合金的其它组分。 在一些实施例中，多孔层适于粘合非金属涂层，包括药物洗脱的聚合物涂层。 多孔层可以具有无规孔结构或定向或定向颗粒多孔结构。 本发明的一个实施方案涉及包括血管支架的医疗装置，其具有适于抵抗狭窄或细胞增殖的至少一个多孔层，而不需要洗脱治疗剂。 本发明还包括将药物和其它治疗剂装载到纳米多孔涂层中的方法，装置和规格。

    USE OF AN IN VITRO HEMODYNAMIC ENDOTHELIAL/SMOOTH MUSCLE CELL CO-CULTURE MODEL TO IDENTIFY NEW THERAPEUTIC TARGETS FOR VASCULAR DISEASE
    5.
    发明申请
    USE OF AN IN VITRO HEMODYNAMIC ENDOTHELIAL/SMOOTH MUSCLE CELL CO-CULTURE MODEL TO IDENTIFY NEW THERAPEUTIC TARGETS FOR VASCULAR DISEASE 有权
    使用体外血液动力学内皮细胞/平滑肌细胞共培养模型来鉴定新的治疗难治性血管病变目标

    公开(公告)号：US20110059480A1

    公开(公告)日：2011-03-10

    申请号：US12901944

    申请日：2010-10-11

    申请人： Brett R. Blackman ,  Brian R. Wamhoff

    发明人： Brett R. Blackman ,  Brian R. Wamhoff

    IPC分类号： C12Q1/02 ,  C12N5/071 ,  C12N5/0793 ,  C12N5/078

    CPC分类号： C12N5/0691 ,  C12N2502/28 ,  C12N2521/00

    摘要： Methods and devices for applying hemodynamic patterns to human/animal cells in culture are described. Hemodynamic flow patterns are measured directly from the human circulation and translated to a motor that controls the rotation of a cone. The cone is submerged in fluid (i.e., cell culture media) and brought into close proximity to the cells. Rotation of the cone creates time-varying shear stresses. This model closely mimics the physiological hemodynamic forces imparted on endothelial cells in vivo. A TRANSWELL coculture dish (i.e., a coculture dish comprising an artificial porous membrane) may be incorporated, permitting two, three, or more different cell types to be physically separated within the culture dish environment. In-flow and out-flow tubing may be used to supply media, drugs, etc. separately and independently to both the inner and outer chambers. The physical separation of the cell types permits each cell type to be separately isolated for analysis.

    摘要翻译： 描述了将血液动力学模式应用于培养中的人/动物细胞的方法和装置。 血流动力学流动模式直接从人体循环测量并转化为控制锥体旋转的马达。 将锥体浸没在流体（即，细胞培养基）中并使其与细胞接近。 锥体的旋转产生时变剪切应力。 该模型密切地模拟体内内皮细胞产生的生理血流动力学。 可以并入TRANSWELL共培养皿（即，包含人造多孔膜的共培养皿），允许在培养皿环境中物理分离两种，三种或更多种不同的细胞类型。 可以使用流入和流出管道将介质，药物等单独和独立地供应到内室和外室。 细胞类型的物理分离允许每个细胞类型被单独隔离用于分析。

    Use of an in vitro hemodynamic endothelial/smooth muscle cell co-culture model to identify new therapeutic targets for vascular disease
    10.
    发明授权
    Use of an in vitro hemodynamic endothelial/smooth muscle cell co-culture model to identify new therapeutic targets for vascular disease 有权
    使用体外血液动力学内皮/平滑肌细胞共培养模型来鉴定血管疾病的新治疗靶点

    公开(公告)号：US07811782B2

    公开(公告)日：2010-10-12

    申请号：US12007483

    申请日：2008-01-10

    申请人： Brett R. Blackman ,  Brian R. Wamhoff

    发明人： Brett R. Blackman ,  Brian R. Wamhoff

    IPC分类号： C12Q1/02 ,  C12N5/07 ,  C12N5/00

    CPC分类号： C12N5/0691 ,  C12N2502/28 ,  C12N2521/00

    摘要： Methods and devices for applying hemodynamic patterns to human/animal cells in culture are described. Hemodynamic flow patterns are measured directly from the human circulation and translated to a motor that controls the rotation of a cone. The cone is submerged in fluid (i.e., cell culture media) and brought into close proximity to the cells. Rotation of the cone creates time-varying shear stresses. This model closely mimics the physiological hemodynamic forces imparted on endothelial cells in vivo. A TRANSWELL coculture dish (i.e., a coculture dish comprising an artificial porous membrane) may be incorporated, permitting two, three, or more different cell types to be physically separated within the culture dish environment. In-flow and out-flow tubing may be used to supply media, drugs, etc. separately and independently to both the inner and outer chambers. The physical separation of the cell types permits each cell type to be separately isolated for analysis.

    摘要翻译： 描述了将血液动力学模式应用于培养中的人/动物细胞的方法和装置。 血流动力学流动模式直接从人体循环测量并转化为控制锥体旋转的马达。 将锥体浸没在流体（即，细胞培养基）中并使其与细胞接近。 锥体的旋转产生时变剪切应力。 该模型密切地模拟体内内皮细胞产生的生理血流动力学。 可以并入TRANSWELL共培养皿（即，包含人造多孔膜的共培养皿），允许在培养皿环境中物理分离两种，三种或更多种不同的细胞类型。 可以使用流入和流出管道将介质，药物等单独和独立地供应到内室和外室。 细胞类型的物理分离允许每个细胞类型被单独隔离用于分析。