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41 条记录 (耗时 0.022 秒)

    Controlled-release pharmaceutical preparation comprising an ACE inhibitor as active ingredient
    1.
    发明授权
    Controlled-release pharmaceutical preparation comprising an ACE inhibitor as active ingredient 失效
    包含ACE抑制剂作为有效成分的控释药物制剂

    公开(公告)号：US06267990B1

    公开(公告)日：2001-07-31

    申请号：US09460055

    申请日：1999-12-13

    申请人： Wilfried Fischer ,  Karin Klokkers ,  Renate Oppelt

    发明人： Wilfried Fischer ,  Karin Klokkers ,  Renate Oppelt

    IPC分类号： A61K916

    CPC分类号： A61K9/5084 ,  A61K31/401

    摘要： The invention relates to a pharmaceutical preparation which comprises or consists of the following components: (i) an initial dose of active ingredient, which is provided by the active ingredient together with optional excipients, (ii) a first delayed-release type of pellet, in which the active ingredient and optional excipients are covered with a coating, and (iii) a second delayed-release type of pellet, in which the active ingredient and optional excipients are again covered with a coating, wherein the active ingredient is an ACE inhibitor, and wherein the amounts of the coatings according to (ii) and (iii) are present in a ratio, based on weight, within the range of from 1:2 to 1:7.

    摘要翻译： 本发明涉及一种药物制剂，其包含或由以下组分组成：（i）活性成分的初始剂量，其由活性成分与任选的赋形剂一起提供，（ii）第一延迟释放型颗粒， 其中活性成分和任选的赋形剂用涂层覆盖，和（iii）第二延迟释放型颗粒，其中活性成分和任选的赋形剂再次用涂层覆盖，其中活性成分是ACE抑制剂 ，并且其中根据（ii）和（iii）的涂料的量以基于重量在1:2至1:7的范围内的比例存在。

    Glass container internally coated with a silicone and having an in situ freeze-dried solid product therein, and process of making the same
    5.
    发明授权
    Glass container internally coated with a silicone and having an in situ freeze-dried solid product therein, and process of making the same 失效
    内部涂有硅树脂并在其中具有原位冻干固体产品的玻璃容器及其制备方法

    公开(公告)号：US5335769A

    公开(公告)日：1994-08-09

    申请号：US972076

    申请日：1992-11-05

    申请人： Karin Klokkers-Bethke ,  Wilfried Fischer

    发明人： Karin Klokkers-Bethke ,  Wilfried Fischer

    IPC分类号： A61J1/05 ,  A61J1/06 ,  B65D1/00 ,  B65D23/02 ,  B65D85/84 ,  A61B19/00

    CPC分类号： A61J1/06 ,  B65D23/02 ,  Y10T428/1321 ,  Y10T428/31612

    摘要： A freeze-drying process which reduces loss of the freeze-dried product comprising adding a liquid solution comprising a solid product dissolved in a solvent to a glass container having its inside surface coated with a silicone material; subjecting the container with the liquid solution therein to acceptable operable freeze-drying conditions to remove the solvent and leave the solid product in the container in the form of a dense compact coherent solid; and sealing the container to maintain the solid product stable over a useful storage shelf life.An article of manufacture comprising a sealed glass container having its inside surface coated with a silicone material and containing an in situ freeze-dried dense compact coherent solid product.

    摘要翻译： 一种降低冷冻干燥产品损失的冷冻干燥方法，包括将溶解在溶剂中的固体产物的液体溶液添加到其内表面涂有硅酮材料的玻璃容器中; 将容器中的液体溶液经受可接受的可操作的冷冻干燥条件以除去溶剂，并将固体产物留在容器中，形式为致密紧密的粘结固体; 并密封容器以保持固体产品在有用的储存保质期内稳定。 一种制品，其包括密封的玻璃容器，其内表面涂覆有硅氧烷材料并且包含原位冷冻干燥的致密紧密相干固体产品。

    Active ingredient patch
    7.
    发明授权
    Active ingredient patch 失效
    活性成分补丁

    公开(公告)号：US5683711A

    公开(公告)日：1997-11-04

    申请号：US535038

    申请日：1995-12-15

    申请人： Wilfried Fischer ,  Karin Klokkers

    发明人： Wilfried Fischer ,  Karin Klokkers

    IPC分类号： A61K9/70 ,  A61K31/355 ,  A61K47/22 ,  A61F13/00 ,  A61K9/14

    CPC分类号： A61K9/7061 ,  A61K9/7069 ,  A61K9/7084

    摘要： The invention relates to an active ingredient patch in the form of a laminate, the patch comprising a carrier and a matrix of a single polymer and if appropriate another polymer and vitamin E.

    摘要翻译： PCT No.PCT / EP94 / 01231 Sec。 371 1995年12月15日第 102（e）日期1995年12月15日PCT 1994年4月20日PCT PCT。 公开号WO94 / 23707 日期：1994年10月27日本发明涉及层压制品形式的活性成分贴剂，该贴剂包含载体和单一聚合物的基质，如果合适的话，还包括另一种聚合物和维生素E.

    Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture
    8.
    发明授权
    Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture 失效
    用活性物质控制释放的口服药物制剂及其制造方法

    公开(公告)号：US5472710A

    公开(公告)日：1995-12-05

    申请号：US235188

    申请日：1994-04-29

    申请人： Karin Klokkers-Bethke ,  Wilfried Fischer

    发明人： Karin Klokkers-Bethke ,  Wilfried Fischer

    IPC分类号： A61K9/50 ,  A61K9/52 ,  A61K9/22 ,  A61K9/24

    CPC分类号： A61K9/5084 ,  A61K9/5078

    摘要： Pharmaceutical preparation to be administered orally with controlled release of active substance and method for its manufacture. Pharmaceutical preparation to be administered orally with controlled release of active substance, containing a nucleus which itself consists at least of one pharmacologically active substance, or a nucleus of physiologically safe material which is enveloped by an active substance layer, containing at least one pharmacologically active substance, if needed, a first membrane, then an acid layer consisting at least of a physiologically safe acid and then a compound membrane consisting of a pH sensitive polymer and an insoluble polymer, as well as methods for its manufacture. The pharmaceutical preparation is applicable to all claimed types of medicine and to the therapy of illnesses.

    摘要翻译： 用活性物质控制释放的口服药物制剂及其制造方法。 含有活性物质的控制释放的药物制剂，其含有至少一种药理学活性物质的细胞核或由活性物质层包围的至少一种药理活性物质的生理安全材料的核， 如果需要，第一膜，然后是至少由生理安全的酸组成的酸层，然后由pH敏感聚合物和不溶性聚合物组成的复合膜，以及其制造方法。 药物制剂适用于所有要求类型的药物和治疗疾病。

    Pharmaceutical preparation with cyclosporin A
    9.
    发明授权
    Pharmaceutical preparation with cyclosporin A 有权
    药物制剂与环孢菌素A

    公开(公告)号：US06696413B2

    公开(公告)日：2004-02-24

    申请号：US09204782

    申请日：1998-12-03

    申请人： Wilfried Fischer ,  Karin Klokkers

    发明人： Wilfried Fischer ,  Karin Klokkers

    IPC分类号： C07K764

    CPC分类号： A61K38/13 ,  A61K9/4858

    摘要： The invention relates to a pharmaceutical preparation which consists of or contains cyclosporin A, an emulsifying &agr;-tocopherol derivative, an ethoxylation product of vegetable oils, fatty acids or fats as a further emulsifier and a pharmaceutically customary alcohol.

    摘要翻译： 本发明涉及由环孢菌素A，乳化α-生育酚衍生物，植物油的乙氧基化产物，脂肪酸或脂肪作为其它乳化剂和药学上常规的醇组成或含有的药物制剂。